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Process for preparation of polycaprolactone-chitosan network/hydroxyapatite porous compound support frame material

A technology of hydroxyapatite and polycaprolactone, which is applied in the field of biomedical engineering, can solve the problems affecting the ability to form new tissues, easy sealing of holes on the surface of materials, and difficulty in solvent removal, so as to achieve good biological properties and improve mechanical properties. The effect of improving performance and compression resistance

Inactive Publication Date: 2007-08-15
FUJIAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gas foaming method, using continuous extrusion equipment to prepare porous polymer composite scaffolds, but the surface pores of the materials prepared by this method are easy to close
The phase separation / emulsification method requires the use of organic solvents, which are usually difficult to remove, making the material somewhat toxic to cells during tissue culture and affecting the ability of tissue cells to form new tissues in vivo
Although the freeze-drying method avoids the use of organic solvents, it is only suitable for the preparation of water-soluble materials

Method used

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  • Process for preparation of polycaprolactone-chitosan network/hydroxyapatite porous compound support frame material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Prepare a 10% polycaprolactone glacial acetic acid solution, take 30 g of the solution, add 0.75 g of chitosan powder, drop in 0.6 ml of water, and stir magnetically until a uniform solution is obtained. Then the solution was slowly poured into a 100ml beaker containing 30g of 40% NaOH solution under stirring, and left to stand for 24 hours to form. After molding, it was taken out and rinsed with distilled water for 10 times, soaked for 24 hours, and dried at 40° C. to obtain a polycaprolactone-chitosan porous scaffold material.

[0021] Prepare 50 ml of a 10% polyvinyl alcohol aqueous solution, add 5 g of nano-hydroxyapatite powder, and ultrasonically vibrate to prepare a hydroxyapatite / polyvinyl alcohol slurry.

[0022] Put the polycaprolactone-chitosan porous scaffold material into a centrifuge tube with a diameter of about 4 cm, and pour the hydroxyapatite / polyvinyl alcohol slurry. Centrifuge at 4000 rpm for 4 minutes, take it out and dry it in a 40°C constant-temp...

Embodiment 2

[0024] Prepare a polycaprolactone glacial acetic acid solution with a mass fraction of 5%, take 30 g of the solution, add 0.16 g of chitosan powder, drop in 0.15 ml of water, and stir magnetically until a uniform solution is obtained. Then the solution was slowly poured into a 100ml beaker containing 30g of 40% NaOH solution under stirring, and left to stand for 24 hours to form. After molding, it was taken out and rinsed with distilled water for 10 times, soaked for 24 hours, and dried at 40° C. to obtain a polycaprolactone-chitosan porous scaffold material.

[0025] Prepare 50 ml of 10% polyvinyl alcohol aqueous solution, add 2.5 g of nano-hydroxyapatite powder, and ultrasonically vibrate to prepare hydroxyapatite / polyvinyl alcohol slurry.

[0026] Put the polycaprolactone-chitosan porous scaffold material into a centrifuge tube with a diameter of about 4 cm, and pour the hydroxyapatite / polyvinyl alcohol slurry. Centrifuge at 10,000 rpm for 5 minutes, take it out and dry it...

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Abstract

The invention discloses a method for preparing polycaprolacton-chitosan / hydroxyapatite nanoparticles porous composite scaffold. The method comprises mixing polycaprolactone with glacial acetic acid to obtain a mixed solution, adding chitosan powder, pouring into NaOH solution, solidifying and oven-drying to obtain polycaprolactone-chitosan porous material; mixing hydroxyapatite nanoparticles to polyvinyl alcohol aqueous solution to obtain a slurry; placing the polycaprolactone-chitosan porous material in a centrifuge tube, and performing grout-filling with the slurry for 3-5 times. The produced composite scaffold has the advantages of good biological and mechanical properties and controllable porosity, and can be widely used as tissue-engineering scaffold for repairing various bone defects.

Description

technical field [0001] The invention relates to a preparation method of a polycaprolactone-chitosan network / hydroxyapatite composite porous support material, belonging to the field of biomedical engineering. Background technique [0002] Tissue engineering provides new methods and ideas for the repair of bone defects. Three-dimensional scaffold materials, that is, extracellular matrix substitutes, are one of the keys to bone tissue engineering research. Bone scaffold materials can not only induce the transformation of surrounding tissues into bone, but also serve as a carrier for transplanted bone cells. They should have good biocompatibility, osteoconductivity, osteoinductivity, and good mechanical properties. However, the existing single material is difficult to meet the requirements of bone tissue engineering for scaffold materials. Based on the concept of bionics - natural bone is an inorganic / organic composite material composed of nano-apatite and polymer collagen fiber...

Claims

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Application Information

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IPC IPC(8): A61L27/42
Inventor 刘榕芳肖秀峰佘厚德林宗琼
Owner FUJIAN NORMAL UNIV
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