Preparation method of antibacterial biological activity ceramic coating with magnetic responsiveness

A technology of bioactive ceramics and magnetic responsiveness, applied in coating, tissue regeneration, drug delivery, etc., can solve problems such as weak binding force, and achieve the effects of promoting proliferation, accelerating new bone formation, and accelerating bone healing

Inactive Publication Date: 2016-09-07
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above-mentioned problems, the present invention proposes a method for preparing a magnetically responsive antibacterial bioactive ceramic coating. The present invention utilizes the super-adhesiveness of polydopamine to realize the self-assembly of inorganic particles and organic formations to form a composite polydopamine Functional coating; the coating prepared by the present invention not only has excellent biocompatibility, bioactivity and antibacterial properties, but also can promote the healing of damaged bone and the formation of new bone under the action of an external magnetic field; the pr

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A method for preparing a magnetically responsive antibacterial bioactive ceramic coating, comprising the following steps:

[0024] Step A: Fe 3 o 4 Particles, Ag 3 PO 4 The particles and hydroxyapatite particles were dispersed in 2 mg / ml alkaline dopamine (DA) solution to obtain Fe at a concentration of 5 mg / ml 3 o 4 Particle dispersion, Ag 3 PO 4 particle dispersion and hydroxyapatite particle dispersion, and then these three inorganic particle dispersions were stirred in the dark for 12 hours, and polydopamine-functionalized Fe 3 o 4 Particles, polydopamine-functionalized antibacterial particles and polydopamine-functionalized bioactive ceramic particles, and the three kinds of inorganic particles were dispersed in distilled water to make a polydopamine-functionalized inorganic particle dispersion with a concentration of 5 mg / ml;

[0025] Step B: Soak the titanium sheet in an alkaline dopamine solution with a concentration of 2 mg / ml, keep it in the dark for 1...

Embodiment 2

[0033] A method for preparing a magnetically responsive antibacterial bioactive ceramic coating, comprising the following steps:

[0034] Step A: Fe 3 o 4 Particles, Ag 3 PO 4 The particles and hydroxyapatite particles were dispersed in 2 mg / ml alkaline dopamine (DA) solution to obtain Fe at a concentration of 5 mg / ml 3 o 4 Particle dispersion, Ag 3 PO 4 particle dispersion and hydroxyapatite particle dispersion, and then the three inorganic particle dispersions were stirred in the dark for 12 hours, and the polydopamine-functionalized Fe 3 o 4 Particles, polydopamine-functionalized antibacterial particles and polydopamine-functionalized bioactive ceramic particles, and the three kinds of inorganic particles were dispersed in distilled water to make a polydopamine-functionalized particle dispersion with a concentration of 10 mg / ml;

[0035] Step B: Soak the titanium sheet in an alkaline dopamine solution with a concentration of 2 mg / ml, keep it in the dark for 12 hours...

Embodiment 3

[0045] : the operation of the present embodiment is basically the same as that of embodiment 1, but the magnetic particles used in embodiment 1 are changed into gamma-Fe 2 o 3 particles.

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Abstract

The invention discloses a preparation method of an antibacterial biological activity ceramic coating with magnetic responsiveness, and belongs to the technical field of biological materials. The preparation method is combined with a layer-by-layer self-assembly technology by using ultrahigh adhesiveness of polydopamine so as to construct a coating of a multilayer film structure on the surface of a base material coated with a polydopamine film. A single layer film is prepared by coating polydopamine functionalized magnetic particle dispersion liquid, polydopamine functionalized antibacterial particle dispersion liquid or polydopamine functionalized biological activity ceramic particle dispersion liquid. The coating prepared through the preparation method has good biocompatibility, biological activity and antibacterial property, the coating can respond to an external magnetic field, and the effect of the external magnetic field can strengthen the osteoinductivity of the coating; the preparation method disclosed by the invention can effectively control the composition, thickness and shape of the coating according to actual requirements; the problems that the binding force between films formed by multilayer inorganic particles in the coating and the binding force between the coating and the base material are not strong are solved. The method has significant research value and clinical significance in bone tissue engineering.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to a preparation method of a magnetically responsive antibacterial bioactive ceramic coating. Background technique [0002] At present, due to the lack of antibacterial properties of biomedical materials in bone tissue engineering, it is easy to cause bacterial infection during the implantation process, resulting in the failure of the implantation operation; in addition, due to the poor surface activity of biomedical materials in bone tissue engineering, after implantation It cannot form a good bond with bone tissue and can only be surrounded by fibrous connective tissue. Its combination with bone tissue and promotion of bone tissue growth are not ideal. In order to solve these problems, it is necessary to prepare bioactive ceramic coatings with antibacterial properties on the surface of biomedical materials. The antibacterial bioactive ceramic coatings pre...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L27/34A61L27/50
CPCA61L27/306A61L27/34A61L27/50A61L2400/18A61L2420/02A61L2420/06A61L2420/08A61L2430/02C08L79/02
Inventor 鲁雄李鹏飞王振铭姜亚楠韩璐谢超鸣王志雄
Owner SOUTHWEST JIAOTONG UNIV
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