Preparation method of antibacterial biological activity ceramic coating with magnetic responsiveness

Abstract

The invention discloses a preparation method of an antibacterial biological activity ceramic coating with magnetic responsiveness, and belongs to the technical field of biological materials. The preparation method is combined with a layer-by-layer self-assembly technology by using ultrahigh adhesiveness of polydopamine so as to construct a coating of a multilayer film structure on the surface of a base material coated with a polydopamine film. A single layer film is prepared by coating polydopamine functionalized magnetic particle dispersion liquid, polydopamine functionalized antibacterial particle dispersion liquid or polydopamine functionalized biological activity ceramic particle dispersion liquid. The coating prepared through the preparation method has good biocompatibility, biological activity and antibacterial property, the coating can respond to an external magnetic field, and the effect of the external magnetic field can strengthen the osteoinductivity of the coating; the preparation method disclosed by the invention can effectively control the composition, thickness and shape of the coating according to actual requirements; the problems that the binding force between films formed by multilayer inorganic particles in the coating and the binding force between the coating and the base material are not strong are solved. The method has significant research value and clinical significance in bone tissue engineering.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to a preparation method of a magnetically responsive antibacterial bioactive ceramic coating. Background technique [0002] At present, due to the lack of antibacterial properties of biomedical materials in bone tissue engineering, it is easy to cause bacterial infection during the implantation process, resulting in the failure of the implantation operation; in addition, due to the poor surface activity of biomedical materials in bone tissue engineering, after implantation It cannot form a good bond with bone tissue and can only be surrounded by fibrous connective tissue. Its combination with bone tissue and promotion of bone tissue growth are not ideal. In order to solve these problems, it is necessary to prepare bioactive ceramic coatings with antibacterial properties on the surface of biomedical materials. The antibacterial bioactive ceramic coatings pre...

AI Technical Summary

Problems solved by technology

[0004] In view of the above-mentioned problems, the present invention proposes a method for preparing a magnetically responsive antibacterial bioactive ceramic coating. The present invention utilizes the super-adhesiveness of polydopamine to realize the self-assembly of inorganic particles and organic formations to form a composite polydopamine Functional coating; the coating prepared by the present invention not only has excellent biocompatibility, bioactivity and antibacterial properties, but also can promote the healing of damaged bone and the formation of new bone under the action of an external magnetic field; the preparation method of the present invention The composition, thickness and shape of the coating can be effectively controlled according to actual needs, the preparation process is simple, the preparation cost is low, and the preparation cycle is short; it solves the problem of the adhesion between the film formed by the multi-layer inorganic particles in the coating and the bonding force between the coating and the substrate The problem is not strong; this method is suitable for preparing ceramic coatings with different membrane systems and thicknesses on the surface of various substrate materials according to actual needs