Bone tissue filling material

A filling material and bone tissue technology, applied in the field of biomedical engineering materials, can solve the problems of insufficient mechanical strength, high price, poor biocompatibility, etc., and achieve the effect of good biocompatibility and low price

Inactive Publication Date: 2004-07-14
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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Problems solved by technology

[0002] Bone tissue filling materials are used in the repair of bone defects, spinal fusion, and cell scaffolds in bone tissue engineering. The traditionally u...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0042] Take the cancellous bone part of calf bone and saw it into 0.7*0.7*1.5cm 3For bone strips, put 500g bone strips into 2000ml water and boil for 13 hours; put bone strips into 1% sodium hydroxide and 1% hydrogen peroxide in 2000ml and soak for 1 hour; To remove excess water, dry the bone strips in a drying oven at 70°C for 72 hours; put the bone strips into a silicon-carbon rod electric furnace for calcination, slowly raise the temperature by 10°C per minute until 800°C, and maintain for 6 hours; immerse the bone strips in In 1000ml, 0.09M sodium pyrophosphate solution, bathe in 70°C water for 72 hours, absorb excess water with filter paper, dry in a drying oven at 70°C for 72 hours; Raise 2.5°C to 1200°C and maintain for 1 hour; slowly cool down to room temperature after power off, immerse the bone strips in 1000ml, 0.26M zinc chloride suspension, 70°C water bath for half an hour, keep stirring in the water bath, use filter paper Absorb excess moisture, and dry in a dry...

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Abstract

The present invention provides a kind of bone tissue filling material. Spongy bone of ox is first treated to become inorganic matter, soaked in sodium pyrophosphate solution, dried and high temperature calcined to produce calcined bone tissue filling material. The filling material is soaked in suspension of zinc chloride, dried and high temperature calcined to obtain the zinc-containing calcined porous bone tissue filling material. The porous bone tissue filling material has low cost, good biocompatibility, homogeneous and communicated pores, certain mechanical strength, capacity of promoting bone growth and other features, and is suitable for filling bone deficiency, spinal column fusion and cell rack in bone tissue engineering, etc.

Description

technical field [0001] The invention belongs to biomedical engineering materials, in particular to bone tissue filling materials. Background technique [0002] Bone tissue filling materials are used in the repair of bone defects, spinal fusion, and cell scaffolds in bone tissue engineering. The traditionally used bone tissue filling materials have poor biocompatibility, high price, insufficient mechanical strength, and cannot effectively promote Insufficient bone growth, etc. Contents of the invention [0003] The purpose of the present invention is to provide a bone tissue filling material, which has the characteristics of low price, good biocompatibility, uniform micropores communicating with each other, certain mechanical strength, and effective promotion of bone growth. At the same time, the invention also provides a planting method of the bone tissue filling material. [0004] The bone tissue filling material provided by the invention is prepared by immersing bovine...

Claims

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Application Information

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IPC IPC(8): A61L27/00A61L31/00A61L31/14
Inventor 郑启新刘苏南郭晓东刘勇
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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