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Porous calcium phosphate bioceramic material and preparing method thereof

A bioceramic material, the technology of calcium phosphate ceramics, applied in the field of biomedical materials, can solve the problems of air pollution, environmental pollution, and the inability to artificially control the pore structure and porosity of porous calcium phosphate ceramics, so as to expand the range of raw materials and improve mechanical properties. performance effect

Inactive Publication Date: 2004-04-14
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] (2) Its porous structure is mainly produced by NH in the process of hydrothermal reaction, hot pressing and setting reaction. 3 It is determined by the evolved gas, so it is difficult to control the pore structure and porosity of the synthesized porous calcium phosphate ceramics;
[0008] (3) NH produced 3 body may pollute the environment
[0012] (1) The porous structure of the porous calcium phosphate ceramics obtained by hydrothermal conversion in an autoclave is mainly determined by the original pore structure of the selected coral, therefore, the pore structure and porosity of the synthesized porous calcium phosphate ceramics cannot be artificially controlled , and the supply of coral raw materials is limited;
[0013] (2) Since the raw materials used to introduce phosphorus are limited by the severity of the reaction, generally (NH 4 ) 2 HPO 4 or (NH 4 )H 2 PO 4 As a raw material for the introduction of phosphorus, therefore, NH will also be produced during the hydrothermal conversion process 3 gas, the produced NH 3 gas may pollute the environment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) According to the molar ratio Ca / P=1.60, the molar ratio of calcium hydrogen phosphate CaHPO 4 .2H 2 O / Calcium Hydroxide Ca(OH) 2 / Calcium Carbonate CaCO 3 = 1.00 / 1.00 / 1.00 ratio to calculate calcium hydrogen phosphate CaHPO 4 .2H 2 O, calcium hydroxide Ca(OH) 2 , Calcium carbonate CaCO 3 And phosphoric acid H 3 PO 4 . Weigh CaHPO 4 .2H 2 O55.71g, Ca(OH) 2 23.97g, CaCO 3 Add 32.39 grams to the beaker, and then add 60ml of distilled water and stir for 30 minutes to obtain a standby mixed slurry;

[0037] (2) Weigh H with a concentration of 85% by weight 3 PO 4 Add 32.65 grams to the beaker, then add 60ml of distilled water to dilute, stir and mix for 3 minutes for later use;

[0038] (3) Slowly add all the diluted phosphoric acid dropwise to the above-mentioned standby mixed slurry under stirring to obtain a uniformly mixed slurry-like mixture;

[0039] (4) The slurry was dried at a temperature of 50°C for 48 hours, ground into powder, and then 15 grams of polystyrene wit...

Embodiment 2

[0043] (1) According to the molar ratio Ca / P=2.00, the molar ratio of tetracalcium phosphate Ca 4 P 2 O 9 / CaHPO 4 .2H 2 O / CaCO 3 = 1.00 / 2.00 / 4.00 ratio calculation Ca 4 P 2 O 9 , CaCO 3 , CaHPO 4 .2H 2 O and H 3 PO 4 . Weigh Ca 4 P 2 O 9 33.76 g CaHPO 4 .2H 2 O31.74g, CaCO 3 Add 36.9 grams into the beaker, then add 120ml of distilled water and stir for 30 minutes to obtain a standby mixed slurry;

[0044] (2) Weigh H with a concentration of 85% by weight 3 PO 4 Add 10.64 grams to the beaker, add 80ml of distilled water to dilute, stir and mix for 3 minutes for use;

[0045] (3) Slowly add all the diluted phosphoric acid dropwise to the above-mentioned standby mixed slurry under stirring to obtain a uniformly mixed slurry-like mixture;

[0046] (4) The slurry was dried at a temperature of 80°C for 36 hours, ground into powder, and then 20 grams of stearic acid with a particle size of 0.42~0.84mm was added, mixed uniformly, and pressed into shape;

[0047] (5) Pretreat the pressed ...

Embodiment 3

[0050] (1) According to the molar ratio Ca / P=1.50, the molar ratio of tricalcium phosphate Ca 3 (PO 4 ) 2 / CaHPO 4 .2H 2 O / Ca(OH) 2 / CaCO 3 = 1.00 / 1.00 / 1.00 / 1.00 ratio calculation Ca 3 (PO 4 ) 2 , CaCO 3 , CaHPO 4 .2H 2 O and H 3 PO 4 . Weigh Ca 3 (PO 4 ) 2 48.23 g CaHPO 4 .2H 2 O26.76g, Ca(OH) 2 11.51g, CaCO 3 Add 15.56 grams to a beaker, add 80ml of distilled water and stir for 30 minutes to obtain a mixed slurry;

[0051] (2) Weigh H with a concentration of 85% by weight 3 PO 4 Add 17.94 grams to the beaker, then add 70ml of distilled water to dilute, and stir for 3 minutes for later use;

[0052] (3) Slowly add all the diluted phosphoric acid dropwise to the above-mentioned standby mixed slurry under stirring to obtain a uniformly mixed slurry-like mixture;

[0053] (4) The slurry was dried at a temperature of 60°C for 48 hours, ground into powder, and then 80 grams of sodium chloride with a particle size of 0.2 to 0.4 mm was added to the slurry, mixed uniformly, and pressed i...

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Abstract

The invention is porous calcium phosphate ceramic material and the manufacturing method. It takes the calcium source and phosphate source according to Ca / P=1.00í½2.00 / 1.00 and computes the quantity of water according to the mol ratio Ca / H2O=1.00.3.00í½20.00, the hole agent / Ca=0.011í½6.00 / 1.00. adds in 0.1í½2.0mm hole agent, upgrades the temperature to 50í½1000íµ fro about 0í½24 hours, and carries on hydro-thermal process. The parameters are: pH is 5í½14, temperature 140í½360íµ, pressure 0.4í½20MPa, the insulated time 0í½24 hours.

Description

1. Technical Field [0001] The invention relates to a porous calcium phosphate bioceramic material and a preparation method thereof, and belongs to the field of biomedical materials. 2. Background technology [0002] The conventional porous calcium phosphate ceramic preparation process includes two steps: the preparation of calcium phosphate ceramic powder and the forming and sintering. That is, the preparation of porous calcium phosphate ceramic requires firstly synthesizing calcium phosphate ceramic powder at high temperature, and then adding the pre-synthesized calcium phosphate ceramic powder. The porogen is formed and then sintered at a high temperature for the second time to obtain porous calcium phosphate ceramics. Japanese patent JP5208877 discloses a method for preparing porous calcium phosphate bioceramics by a sintering method: organic materials with spherical pores and calcium phosphate ceramic powder are mixed and pressed into a shape according to a certain weight rat...

Claims

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Application Information

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IPC IPC(8): A61F2/28A61L27/12C04B35/447C04B38/00
Inventor 黄永前
Owner SICHUAN UNIV
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