An anti-allergic repair composition, application, and preparation method

Abstract

The present invention relates to the technical field of daily chemicals, and in particular to an anti-allergic repair composition, application, and preparation method. The repair composition comprises: gentian root extract, chamomile flower extract, licorice inflata extract, butylene glycol, and water. The anti-allergic repair provided by the present invention is compounded with plant extracts to achieve better anti-allergic repair effects, enhance skin immunity, and reduce skin sensitivity.

Description

Technical Field

[0001] The present invention relates to the technical field of daily chemicals, and in particular to an anti-allergic repairing composition, an application and a preparation method thereof. Background Art

[0002] Skin allergy is an abnormal reaction of the body, an abnormal reaction of people to normal substances (allergens). When allergens come into contact with people with allergic constitutions, allergies will occur. Allergens include pollen, dust, foreign proteins, chemicals, ultraviolet rays, etc. In the process of allergic reactions, allergic mediators play a direct role. Allergens are the external cause of allergic symptoms, while low immune capacity and oxidative damage of mast cells and basophils by a large number of free radicals are the internal causes of allergies.

[0003] The use of cosmetics can also cause skin allergies. Glucocorticoids are often used to treat skin allergies, but their long-term use can easily lead to side effects such as skin atrophy, capillary dilation, acne pigment abnormalities and photosensitivity, which only treats the symptoms but not the root cause.

[0004] CN111632013A provides a soothing and repairing composition, a soothing and repairing powder preparation and a preparation method thereof, which belong to the field of cosmetics. The soothing and repairing composition of the present invention comprises madecassoside and mussel extract; wherein the amount of madecassoside added is 0.1-15 parts by weight, and the amount of mussel extract added is 0.5-25 parts by weight. The soothing and repairing composition of the present invention has a good soothing and repairing effect. The soothing and repairing powder preparation of the present invention has good uniformity, novel appearance, light and easy to release water when applied, fresh release of active ingredients, unique experience, and soothing and repairing and instant oil control effects, and is particularly suitable for use by people with allergic skin.

[0005] In view of the above phenomenon, the present invention provides an anti-allergic repair composition, application and preparation method. Summary of the invention

[0006] In order to solve the above technical problems, the present invention provides an anti-allergic repair composition, which comprises:

[0007] Gentiana Root Extract

[0008] Chamomile Flower Extract

[0009] Licorice Extract

[0010] Butanediol

[0011] water.

[0012] As an embodiment of the present invention, the repair composition comprises, by weight:

[0013] Gentiana root extract 0.1-10 parts

[0014] Chamomile flower extract 0.01-0.1 parts

[0015] 1-5 parts of Glycyrrhiza inflata extract

[0016] Butanediol 50-67.88 parts

[0017] 25-50 parts of water.

[0018] As an embodiment of the present invention, the composition further comprises a Sophora flavescens root extract.

[0019] The second aspect of the present invention provides an anti-allergic repair skin care product, comprising the anti-allergic repair composition.

[0020] As an embodiment of the present invention, the raw materials for preparing the anti-allergic repair skin care product include:

[0021] Disodium EDTA; methanol; allantoin; acrylamide / sodium acryloyldimethyltaurate / acrylic acid copolymer ec66; carbomer 941; erythritol; butylene glycol; arginine; water; asiatica glycoside; niacinamide; arbutin; bifida yeast liquid; the anti-allergic repair composition; moisturizer M268, PEG-40 hydrogenated ramie oil.

[0022] As an embodiment of the present invention, the skin care product further comprises rice fermentation liquid, roxburghii extract and camellia extract.

[0023] As an embodiment of the present invention, the preparation method of the Glycyrrhiza inflata extract is as follows:

[0024] S01 Select Glycyrrhiza inflata seeds, plant them in soil to get seedlings, then cut the young shoots with a knife, wash them alternately with anhydrous ethanol and deionized water for 3 times, and finally sterilize them with 2% sodium hypochlorite for 3 minutes, and finally wash them with deionized water for 10 seconds;

[0025] S02 placing the seedling obtained in step S01 in a callus induction medium for culturing to obtain callus;

[0026] S03 Select callus tissue with healthy growth, vigorous metabolism and loose structure for cryopreservation;

[0027] S04 When needed, take out the frozen plant callus cells, thaw them under running water at 40°C, place them in a culture medium for culture, and then filter out the culture medium to obtain a Glycyrrhiza inflata extract.

[0028] As an embodiment of the present invention, the preparation method of the rice fermentation liquid is as follows:

[0029] (A1) mixing rice and glutinous rice in a mass ratio of 3:1, adding 1.2 times the volume of water to soak, steaming to obtain cooked rice, and cooling;

[0030] (A2) inoculating Aspergillus oryzae into the cooked rice in step (A1), wherein the inoculated mass of Aspergillus oryzae accounts for 1% of the mass of the cooked rice, and then cultivating the cooked rice at a temperature of 25-27° C. and a humidity of 70-80% for 6-9 days, and obtaining the rice fermentation liquid by centrifugation and filtration.

[0031] The third aspect of the present invention provides a method for preparing the anti-allergic repair skin care product, comprising the following steps:

[0032] Preparation of S01 pre-phase:

[0033] Phase A2: Mix and stir in a container at room temperature to disperse evenly;

[0034] Phase C: Mix and stir at room temperature to dissolve completely into a transparent liquid;

[0035] Phase D: Mix and stir at room temperature to dissolve completely into a transparent liquid;

[0036] S02 At room temperature, add the A1 phase raw materials into the emulsifying pot in sequence, start medium-speed homogenization, add the A2 phase and homogenize for 3-5 minutes to disperse evenly, then add the A3 phase and homogenize for 2-3 minutes to disperse evenly, then start heating and stirring to raise the temperature to 85-88°C, keep warm and stir for 20 minutes;

[0037] S03 Add the raw materials of phase B into the emulsifying pot in sequence, stir and mix evenly, keep the temperature at 80-85℃, homogenize at medium-high speed for 3-5 minutes to ensure that the material is milky white, uniform and delicate, and then keep warm and stir for 10 minutes;

[0038] Cool S04 to 60-65℃, add dissolved phase C, and stir to mix evenly;

[0039] S05 is cooled to 45-48℃ and the dissolved D phase is added in sequence, stirred and mixed evenly to obtain the product.

[0040] A1: disodium EDTA; methanol; allantoin, water, bifid yeast solution, butanediol, rice fermentation solution

[0041] A2: Acrylamide / Sodium Acryloyldimethyl Taurate / Acrylic Acid Copolymer ec66; Carbomer 941, Water B: PEG-40 Hydrogenated Ramie Oil

[0042] D: Arginine, Water, Erythritol

[0043] E: Centella asiatica glycoside; niacinamide; arbutin; the anti-allergic repair composition; moisturizer M268, water, roxburghii extract, camellia extract.

[0044] The ratio of water in A1, A2, D and E is 20:1:0.1:5.

[0045] The fourth aspect of the present invention provides a method for preparing the anti-allergic and repairing skin care product, which is applied in the field of daily chemicals.

[0046] By adopting the above technical solution, the present invention has the following beneficial effects:

[0047] 1. The anti-allergic repair provided by the present invention is compounded with plant extracts to achieve better anti-allergic repair effects, enhance skin immunity, and reduce skin sensitivity;

[0048] 2. At the same time, it can provide better protection and repair for consumers who are already seriously injured. BRIEF DESCRIPTION OF THE DRAWINGS

[0049] In order to more clearly illustrate the specific implementation methods of the present invention or the technical solutions in the prior art, the drawings required for use in the specific implementation methods or the description of the prior art will be briefly introduced below. Obviously, the drawings in the following description are some implementation methods of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0050] Figure 1 This is a product picture of the anti-allergic repair composition of Example 1. DETAILED DESCRIPTION

[0051] The technical solution of the present invention will be described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0052] The present invention is further explained below in conjunction with specific implementation modes.

[0053] An anti-allergic repair composition, comprising:

[0054] Gentiana root extract 0.55

[0055] Chamomile flower extract 0.055

[0056] 3 parts of Glycyrrhiza inflata extract

[0057] Butanediol 58.84 parts

[0058] 37.5 parts of water.

[0059] Preferably, the repair composition further comprises: 0.055 parts of Sophora flavescens root extract.

[0060] An anti-allergic repair skin care product, comprising:

[0061] 0.05 parts of disodium EDTA

[0062] Methanol 0.15 parts

[0063] Allantoin 0.2 parts

[0064] Acrylamide / sodium acryloyldimethyl taurate / acrylic acid copolymer ec66 0.1 parts

[0065] Kapo 941 0.25

[0066] 1 part erythritol

[0067] 8 parts of Butanediol

[0068] Arginine 0.25 parts

[0069] 0.2 parts of Centella asiatica

[0070] 1 part niacinamide

[0071] Arbutin 0.3 parts

[0072] 1 portion of bifid yeast solution

[0073] 1 portion of rice fermented liquid

[0074] 1 anti-allergic repair composition

[0075] Moisturizer M268 0.7 parts

[0076] 0.1 part of roxburghii extract

[0077] Camellia extract 0.005 parts

[0078] PEG-40 hydrogenated ramie oil 0.015 parts

[0079] Add water to 100 parts.

[0080] Among them: EC-66: EC-66, Acrylamide / Sodium Acryloyldimethyl Taurate / Acrylic Acid Copolymer.

[0081] 941: Carbomer;

[0082] M268: Hanaco M268, contains: dipropylene glycol 50-60%, 1,2-hexanediol 25-30%, caprylyl glycol 12-16%, ethylhexylglycerin 2-6%.

[0083] Licorice Extract

[0084] The preparation method of the Glycyrrhiza inflata extract is as follows:

[0085] S01 Select Glycyrrhiza inflata seeds, plant them in soil to get seedlings, then cut the young shoots with a knife, wash them alternately with anhydrous ethanol and deionized water for 3 times, and finally sterilize them with 2% sodium hypochlorite for 3 minutes, and finally wash them with deionized water for 10 seconds;

[0086] S02 placing the seedling obtained in step S01 in a callus induction medium for culturing to obtain callus;

[0087] The callus induction medium comprises: MS fixed medium (7% agar), 0.4 mg / L 6-benzyladenine, 7.5 mg / L a-naphthyl acetate, and 50 g / L sucrose; the culture conditions are: dark culture at 28±1° C. for 24 h, followed by light for 8 h every day; and culture for 10 days.

[0088] S03 Select callus tissue with healthy growth, vigorous metabolism and loose structure and store it at -196℃;

[0089] S04 When needed, the frozen plant callus cells are taken out, thawed under running water at 40°C, and then placed in a culture medium for culture, and then the culture medium is filtered out to obtain a Glycyrrhiza inflata extract.

[0090] In the S04, the culture medium components are:

[0091] MS medium, sucrose 25g / L, 2,4-dichlorophenoxyacetic acid (2,4-D) 1.5mg / L, inositol 110mg / L, 6-BA 3.5mg / L, NAA 0.5mg / L, choline 1.2g / L, gentian root extract, chamomile flower extract and 1L water.

[0092] The culture conditions were: 8 days of culture, low light (105 μE m -2 s -1 ) conditions.

[0093] Rice fermented liquid

[0094] As an embodiment of the present invention, the preparation method of the rice fermentation liquid is as follows:

[0095] (A1) mixing rice and glutinous rice in a mass ratio of 3:1, adding 1.2 times the volume of water to soak, steaming to obtain cooked rice, and cooling;

[0096] (A2) inoculating Aspergillus oryzae into the cooked rice in step (A1), wherein the inoculated mass of Aspergillus oryzae accounts for 1% of the mass of the cooked rice, and then cultivating the cooked rice at a temperature of 25-27° C. and a humidity of 70-80% for 6 days, and obtaining the rice fermentation liquid by centrifugation and filtration.

[0097] The Aspergillus oryzae is: Aspergillus oryzae CICC 2339, China Industrial Microbiological Culture Collection Management Center.

[0098] Example 1

[0099] This embodiment provides an anti-allergic repair skin care product, comprising:

[0100] 0.05 parts of disodium EDTA

[0101] Methanol 0.15 parts

[0102] Allantoin 0.2 parts

[0103] Acrylamide / sodium acryloyldimethyl taurate / acrylic acid copolymer ec66 0.1 parts

[0104] Kapo 941 0.25

[0105] 1 part erythritol

[0106] 8 parts of Butanediol

[0107] Arginine 0.25 parts

[0108] 0.2 parts of Centella asiatica

[0109] 1 part niacinamide

[0110] Arbutin 0.3 parts

[0111] 1 portion of bifid yeast solution

[0112] 1 portion of rice fermented liquid

[0113] 1 anti-allergic repair composition

[0114] Moisturizer M268 0.7 parts

[0115] 0.1 part of roxburghii extract

[0116] Camellia extract 0.005 parts

[0117] PEG-40 hydrogenated ramie oil 0.015 parts

[0118] Add water to 100 parts.

[0119] Among them: EC-66: EC-66, Acrylamide / Sodium Acryloyldimethyl Taurate / Acrylic Acid Copolymer.

[0120] 941: Carbomer;

[0121] M268: Hanaco M268, contains: dipropylene glycol 50-60%, 1,2-hexanediol 25-30%, caprylyl glycol 12-16%, ethylhexylglycerin 2-6%.

[0122] The preparation method of the Glycyrrhiza inflata extract is as follows:

[0123] S01 Select Glycyrrhiza inflata seeds, plant them in soil to get seedlings, then cut the young shoots with a knife, wash them alternately with anhydrous ethanol and deionized water for 3 times, and finally sterilize them with 2% sodium hypochlorite for 3 minutes, and finally wash them with deionized water for 10 seconds;

[0124] S02 placing the seedling obtained in step S01 in a callus induction medium for culturing to obtain callus;

[0125] The callus induction medium comprises: MS fixed medium (7% agar), 0.4 mg / L 6-benzyladenine, 7.5 mg / L a-naphthyl acetate, and 50 g / L sucrose; the culture conditions are: dark culture at 28±1° C. for 24 h, followed by light for 8 h every day; and culture for 10 days.

[0126] S03 Select callus tissue with healthy growth, vigorous metabolism and loose structure and store it at -196℃;

[0127] S04 When needed, the frozen plant callus cells are taken out, thawed under running water at 40°C, and then placed in a culture medium for culture, and then the culture medium is filtered out to obtain a Glycyrrhiza inflata extract.

[0128] In the S04, the culture medium components are:

[0129] MS medium, sucrose 25g / L, 2,4-dichlorophenoxyacetic acid (2,4-D) 1.5mg / L, inositol 110mg / L, 6-BA 3.5mg / L, NAA 0.5mg / L, choline 1.2g / L, gentian root extract, chamomile flower extract and 1L water.

[0130] The culture conditions were: 8 days of culture, low light (105 μE m -2 s -1 ) conditions.

[0131] The preparation method of the rice fermented liquid is as follows:

[0132] (A1) mixing rice and glutinous rice in a mass ratio of 3:1, adding 1.2 times the volume of water to soak, steaming to obtain cooked rice, and cooling;

[0133] (A2) inoculating Aspergillus oryzae into the cooked rice in step (A1), wherein the inoculated mass of Aspergillus oryzae accounts for 1% of the mass of the cooked rice, and then cultivating the cooked rice at a temperature of 25-27° C. and a humidity of 70-80% for 6 days, and obtaining the rice fermentation liquid by centrifugation and filtration.

[0134] The Aspergillus oryzae is: Aspergillus oryzae CICC 2339, China Industrial Microbiological Culture Collection Management Center.

[0135] The repair composition comprises:

[0136] Gentiana root extract 0.55

[0137] Matricaria extract 0.055

[0138] 3 parts of Glycyrrhiza inflata extract

[0139] Butanediol 58.84 parts

[0140] 37.5 parts water

[0141] 0.055 parts of Sophora flavescens root extract.

[0142] Example 2

[0143] The difference from Example 1 is that the ingredients of Example 2 do not contain rice fermentation liquid.

[0144] Example 3

[0145] The difference from Example 1 is that the licorice extract is commercially available and purchased from Xi'an Lishi Biotechnology Co., Ltd.

[0146] Example 4

[0147] The difference from Example 1 is that the preparation method of the licorice extract is as follows: S01 select Glycyrrhiza inflata seeds, plant them in soil to obtain tender seedlings, then cut tender shoots with a knife, wash them alternately with anhydrous ethanol and deionized water for 3 times, and finally sterilize them with 2% sodium hypochlorite for 3 minutes, and finally wash them with deionized water for 10 seconds;

[0148] S02 placing the seedling obtained in step S01 in a callus induction medium for culturing to obtain callus;

[0149] The callus induction medium comprises: MS fixed medium (7% agar), 0.4 mg / L 6-benzyladenine, 7.5 mg / L a-naphthyl acetate, and 50 g / L sucrose; the culture conditions are: dark culture at 28±1° C. for 24 h, followed by light for 8 h every day; and culture for 10 days.

[0150] S03 Select callus tissue with healthy growth, vigorous metabolism and loose structure and store it at -196℃;

[0151] S04 When needed, take out the frozen plant callus cells, thaw them under running water at 40°C, place them in a culture medium for culture, and then filter out the culture medium to obtain a Glycyrrhiza inflata extract.

[0152] In the S04, the culture medium components are:

[0153] MS medium, sucrose 25 g / L, 2,4-dichlorophenoxyacetic acid (2,4-D) 1.5 mg / L, inositol 110 mg / L, 6-BA 3.5 mg / L, NAA 0.5 mg / L, choline 1.2 g / L and 1 L of water.

[0154] The culture conditions were: 8 days of culture, low light (105 μE m -2 s -1 ) conditions.

[0155] Example 5

[0156] The difference from Example 1 is that the ingredients of Example 5 do not contain Sophora flavescens extract.

[0157] Example 6

[0158] The difference from Example 1 is that the ingredients of Example 6 do not contain the roxburghii extract.

[0159] Performance Testing

[0160] Test 1: The skin care products prepared in Examples 1 to 6 were placed at 0°C, 25°C, and 40°C for 90 days to check the properties and color of the products. The test results are shown in Table 1.

[0161] Table 1 Test results of performance test 1

[0162] Example 0℃ 25℃ 40℃ Example 1 No change No change No change Example 2 No change Layering Layering Example 3 No change No change No change Example 4 Darkening Darkening Darkening Example 5 No change No change No change Example 6

[0163] Test 2: Toxicology test:

[0164] 1. Testing standard: "Technical Specification for Safety of Cosmetics" (2015 Edition) Chapter 6 5 Acute Eye Irritation and Corrosion Test

[0165] 2. Testing environment: general environment animal room, experimental animal use license number: SYXK(Guangdong)2022-0198, temperature: 18-26℃, relative humidity: 40-70%.

[0166] 3. Experimental animals and feed: 6 ordinary New Zealand rabbits, female weighing 2.15-2.28kg, no abnormality in eyes after examination, experimental animals purchased with animal production license number: SCXK (Guangdong) 2019-0023, quality certificate from Guangzhou Huadong Xinhua Experimental Animal Breeding Farm, Experimental Collaborative Pharmaceutical Bioengineering Co., Ltd., certificate number: No. 44007600010592. Feed was purchased from Jiangsu OC20230300207901.

[0167] Test method:

[0168] a) Exposure: Gently pull open the lower eyelid of one eye of the rabbit, and drop the test substance into the conjunctival sac at 0.1 mL / eye, so that the upper and lower eyelids are passively closed for 1 second. The other eye is not treated as a self-control. Do not rinse the eyes within 24 hours after the test substance is dropped. After the 24-hour observation and recording, further examination of the eyes of all animals with sodium fluorescein b) Animal observation: Check the eyes of animals 1, 24, 48, 72 hours, and on the 4th and 7th day after the test substance is dropped. If there is no film or other eye irritation within 72 hours, and it does not recover within 7 days, the test can be terminated to determine the occurrence of irritation. If the reversibility or irreversibility of the involved angle damage is found, the observation time needs to be extended, generally not more than 21 days, and observation reports for 7 days, 14 days and 21 days are provided. Except for the immediate, all should be recorded and reported. In each examination, in addition to observing the cornea, iris, and conjunctiva of the eye damage, the score of other damage effects should be recorded according to the scoring standards.

[0169] The score of 0 means no irritation, and the larger the score, the greater the irritation. The irritation intensity of the test substance to the eye is determined by evaluating the mean of the irritation response score of the cornea, iris or conjunctiva of the animal at 24, 48 and 72 hours after administration of the test substance and the recovery time according to the eye irritation response classification in the table below.

[0170] Table 2 Results of acute eye irritation test on rabbits by subjects

[0171]

[0172]

[0173] Test 3:

[0174] Transepidermal water loss difference

[0175] Healthy subjects aged 25-60 years old (all subjects already have sensitive skin characteristics, such as allergies, redness, etc.), including 4 males and 28 females, with an average age of 45.22 years old.

[0176] Part used: hand and forearm

[0177] Usage: When used on the forearm, the test sample is (2.0±0.1) mg / cm 2 Apply a single application of the dosage and use a latex finger cot to evenly spread the sample in the test area.

[0178] Test steps

[0179] The subjects did not touch the inner part of their arms with water before the visit.

[0180] Before the experiment, the subjects were required to uniformly clean their arms with dry facial tissue;

[0181] Mark two measurement areas on the inside of the subject's left or right arm, each area is 3cm*3cm, and the distance between the areas is at least 1cm;

[0182] The sample area and negative control area were randomly distributed in the calibration area to ensure that each area was statistically balanced: the subjects exposed their arms and rested for 30 minutes in an environment with a temperature of 21±1°C and a relative humidity of 50±10%RH; the inducer (0.1% histamine solution) was applied to the sample area and the negative area for 10 minutes. After the application and before using the sample (Timm), the transepidermal water loss rate of the calibration area was tested with Tewameter, and the hemoglobin of the calibration area was tested with Mexamter;

[0183] Use the samples in the designated sample area according to the sample usage instructions;

[0184] After using the sample, the subjects rested their arms in an environment with a temperature of 21±1℃ and a relative humidity of 50±10%RH for 2 hours. After 1 hour (T1), the transepidermal water loss rate of the calibrated area was tested with a Tewameter.

[0185] After 1 h (T1), the hemoglobin in the marked area was tested using Mexamter;

[0186] The subjects filled in the self-assessment questionnaire 5 minutes (immediately), 30 minutes, and 2 hours after using the sample, and filled in the satisfaction questionnaire 2 hours later.

[0187] Transepidermal water loss rate difference

[0188] Courage+Khazaka Transepidermal Water Loss and Water Evaporation Heat Loss Test Probe Tewameter TM300 is used to detect the transepidermal water loss rate of the skin. The difference in transepidermal water loss rate refers to the difference in transepidermal water loss rate of the calibrated area before and 1 hour after the sample is used. The calculation formula is:

[0189] Transepidermal water loss rate difference = transepidermal water loss rate (Timm) - transepidermal water loss rate (T1). The larger the measurement value, the better the recovery of the skin's transepidermal water loss rate.

[0190] Table 3 Comparison of transepidermal water loss rate before and after

[0191] Example Same as before (mean ± standard deviation) After 1 hour of use (mean ± standard deviation) Example 1 13.40±2.19 9.14±1.03 Example 2 13.32±1.76 11.65±1.98 Example 3 13.32±1.98 12.21±2.76 Example 4 13.28±2.05 11.34±2.06 Example 5 13.35±1.32 12.64±1.76 Example 6 13.22±1.39 12.42±2.36 Negative area 13.21±2.29 12.89±2.17

[0192] Heme difference.

[0193] Courage+Khazaka Skin Melanin and Hemoglobin Tester Mexamter MX18 is used to detect skin hemoglobin. The hemoglobin difference refers to the difference in hemoglobin in the calibration area before and after 1 hour of sample use. The calculation formula is:

[0194] Hemoglobin difference = hemoglobin (Timm) - hemoglobin (T1)

[0195] The larger the measurement value, the better the recovery of skin redness.

[0196] Table 4 Comparison of hemoglobin before and after

[0197] Example Same as before (mean ± standard deviation) After 1 hour of use (mean ± standard deviation) Example 1 304.30±50.32 159.58±42.05 Example 2 304.45±42.74 169.63±35.63 Example 3 304.13±49.32 198.23±29.74 Example 4 305.03±51.73 167.23±31.87 Example 5 304.68±33.83 203.67±43.82 Example 6 304.82±41.02 201.34±40.41 Negative area 305.52±55.39 290.79±53.44

[0198] Figure 1 This is a product picture of the anti-allergic repair composition of Example 1.

[0199] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. An anti-allergic repair skin care product, characterized in that: The skin care product comprises: 0.05 parts of disodium EDTA Methanol 0.15 parts Allantoin 0.2 parts Acrylamide / sodium acryloyldimethyl taurate / acrylic acid copolymer ec66 0.1 parts Kapo 941 0.25 1 part erythritol 8 parts of Butanediol Arginine 0.25 parts 0.2 parts of Centella asiatica 1 part niacinamide Arbutin 0.3 parts 1 portion of bifid yeast solution 1 portion of rice fermented liquid 1 anti-allergic repair composition Moisturizer M268 0.7 parts 0.1 part of roxburghii extract Camellia extract 0.005 parts PEG-40 hydrogenated ramie oil 0.015 parts Add water to 100 parts; Among them, M268 contains: dipropylene glycol 50-60%, 1,2-hexanediol 25-30%, caprylyl glycol 12-16%, ethylhexylglycerin 2-6%; The anti-allergic repair composition comprises: Gentiana root extract 0.55 parts 0.055 parts of chamomile flower extract 3 parts of Glycyrrhiza inflata extract Butanediol 58.84 parts 37.5 parts of water; The preparation method of the Glycyrrhiza inflata extract is as follows: S01 Select Glycyrrhiza inflata seeds, plant them in the soil to get seedlings, then cut the young shoots with a knife, wash them alternately with anhydrous ethanol and deionized water for 3 times, and finally sterilize them with 2% sodium hypochlorite for 3 minutes, and finally wash them with deionized water for 10 seconds; S02 placing the seedlings obtained in step S01 in a callus induction medium for culturing to obtain callus tissue; S03 Select callus tissue with healthy growth, vigorous metabolism and loose structure for cryopreservation; S04 when needed, taking out the frozen plant callus cells, thawing them under running water at 40° C., and then culturing them in a culture medium, and then filtering and removing the culture medium to obtain a Glycyrrhiza inflata extract; The callus induction medium comprises: 7% agar MS fixed medium, 0.4 mg / L 6-benzyladenine, 7.5 mg / L a-naphthaleneacetic acid, 50 g / L sucrose; culture conditions: dark culture at 28±1°C for 24 hours, then light is added for 8 hours every day; culture for 10 days; In the S04, the culture medium components are: MS culture medium, 25 g / L sucrose, 1.5 mg / L 2,4-dichlorophenoxyacetic acid, 110 mg / L inositol, 3.5 mg / L 6-BA, 0.5 mg / L NAA, 1.2 g / L choline, gentian root extract, chamomile flower extract and 1 L water; The culture conditions were: 8 days of culture, weak light 105 μE m -2 s -1 Cultivated under conditions.

2. The anti-allergic repair skin care product according to claim 1, characterized in that: The preparation method of the rice fermented liquid is as follows: (A1) mixing rice and glutinous rice in a mass ratio of 3:1, adding 1.2 times the volume of water to soak, steaming to obtain cooked rice, and cooling; (A2) inoculating Aspergillus oryzae into the cooked rice in step (A1), wherein the inoculated mass of Aspergillus oryzae accounts for 1% of the mass of the cooked rice, and then cultivating the cooked rice at a temperature of 25-27° C. and a humidity of 70-80% for 6-9 days, and obtaining the rice fermentation liquid by centrifugation and filtration.

3. The method for preparing an anti-allergic repair skin care product according to claim 1, characterized in that: Here are the steps: Preparation of S01 pre-phase: Phase A2: Mix and stir in a container at room temperature to disperse evenly; Phase C: Mix and stir at room temperature to dissolve completely into a transparent liquid; Phase D: Mix and stir at room temperature to dissolve completely into a transparent liquid; S02 At room temperature, add the A1 phase raw materials into the emulsifying pot in sequence, start medium-speed homogenization, add the A2 phase and homogenize for 3-5 minutes to disperse evenly, then add the A3 phase and homogenize for 2-3 minutes to disperse evenly, then start heating and stirring to raise the temperature to 85-88℃, keep warm and stir for 20 minutes; S03 Add the raw materials of phase B into the emulsifying pot in sequence, stir and mix evenly, keep the temperature at 80-85℃, homogenize at medium-high speed for 3-5 minutes to ensure that the material is milky white, uniform and delicate, and then keep the temperature and stir for 10 minutes; S04 cools down to 60-65℃, adds dissolved C phase, and stirs to mix evenly; S05 is cooled to 45-48℃ and the dissolved D phase is added in sequence and stirred to mix evenly. in: A1: disodium EDTA; methanol; allantoin, water, bifid yeast solution, butanediol, rice fermentation solution; A2: Acrylamide / sodium acryloyldimethyl taurate / acrylic acid copolymer ec66; Carbopol 941, water; B: PEG-40 hydrogenated ramie oil; D: arginine, water, erythritol; E: Centella asiatica; niacinamide; arbutin; the anti-allergic repair composition; moisturizer M268, water, roxburghii extract, camellia extract; The ratio of water in A1, A2, D and E is 20:1:0.1:

5.

4. The method for preparing an anti-allergic repair skin care product according to claim 3, characterized in that: Applied in daily chemical field.

Images