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Automatic device for evaluating memory function of primate experimental animal

A technology of experimental animals and automatic devices, which is applied in the field of evaluation of animal visual cognitive ability, and can solve problems such as evaluation interference of animal cognitive ability

Active Publication Date: 2015-06-03
广西南宁灵康赛诺科生物科技有限公司
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AI Technical Summary

Problems solved by technology

The cognitive task test carried out by the existing short-term memory test method WGTA (Wisconsin General Test Apparatus) is an interactive mode in which the experimenter and the animal directly interact to complete the experimental task. In this interactive mode, although the animal can adapt Experimental task, but the experimenter effect will cause some interference to the assessment of animal cognitive ability

Method used

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  • Automatic device for evaluating memory function of primate experimental animal
  • Automatic device for evaluating memory function of primate experimental animal
  • Automatic device for evaluating memory function of primate experimental animal

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Embodiment Construction

[0047] The present invention will be described in detail below in conjunction with the accompanying drawings and embodiments.

[0048] 1. Experimental animals

[0049] The present invention adopts 20 healthy old age cynomolgus monkeys, wherein 15 female monkeys, 5 male monkeys, age 10-15 (average 12.5) years old, through routine quarantine and physical examination, no limb damage, normal behavior habits of animals are complete, by Provided by Guangxi Xiongsen Primate Breeding Center. In the later stage of the experiment, 10 cynomolgus monkeys were injected with MPTP at a dose of 0.2mg / kg to obtain a stable early hemiparkinsonian animal model mimicking human Parkinson's disease. The company's AAALAC (Association for Assessment and Accreditation of Laboratory Animal) international qualification certification laboratory has been completed.

[0050] 2. Experimental device

[0051] The test adopts the automatic device of the present invention to evaluate the memory function of p...

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Abstract

The invention discloses an automatic device for evaluating the memory function of a primate experimental animal and a method for evaluating the memory function of the primate experimental animal. The device comprises an experimental operation cage (1), a touch display screen (15), a horizontal exhibition stand (12), an infrared ray sensing automatic award food distributor (16) and a main control computer (19). Through interactive operation of the touch display screen and the animal, direct interactive operation between experiment personnel and the animal is avoided, and the evaluation of the cognitive ability is more objective. Through the device, the brain function can be evaluated subjectively according to a judgment made by a tester. The device and the method are particularly suitable for evaluating the cognitive memory of primate animals, particularly old non-human primate experimental animals and disease model non-human primate experimental animals.

Description

technical field [0001] The invention belongs to the field of evaluation of animal visual cognitive ability, and relates to an automatic device for evaluating short-term visual memory, in particular to a set of automatic devices for evaluating the memory function of primate experimental animals. Background technique [0002] Vision is the most important channel for animals to perceive the external environment, and it is of great significance for revealing the working mechanism of the brain. Therefore, more and more researchers pay attention to the study of animal visual learning and memory functions. Through the development and design of various experimental devices and experimental programs, and These experimental devices and implementation schemes are used in researches such as screening drugs that affect cognitive behavior and exploring the mechanism of action of drugs on cognitive behavior. The basic design principle of the animal visual learning and cognitive experiment ...

Claims

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Application Information

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IPC IPC(8): A01K15/02
CPCA01K15/027
Inventor 岳峰韦伟陶国现张国栋唐荣平
Owner 广西南宁灵康赛诺科生物科技有限公司
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