The invention discloses liver protection sober-up soft sweets and a preparation process thereof. Hovenia acerba, radix puerariae, mulberry fruits, dandelions, plantain herbs, rhizoma polygoni cuspidati, fructus ligustri lucidi, radix bupleuri, radix scutellariae, gingers, codonopsis pilosula, liquorice roots, jujube and lucid ganoderma are fermented by using microorganisms, filtered, and vacuum concentrated to obtain medicinal-edible plant formula extract solution, the medicinal-edible plant formula extract solution is mixed with substances such as glucose, fructose and carrageenan to be made into a novel soft sweet product for dispelling the alcohol effect, protecting liver, facilitating urine, benefiting gallbladder and supplementing energy. The soft sweet is of a carrier form, not only contains sufficient functional substances, but also can supplement the excessively consumed energy of a human body in time. By adopting the microorganism fermentation extraction technology, the medicinal and edible plant resources are efficiently utilized, the obtained new product is convenient to carry and eat and delicious in taste, the effect for dispelling the alcohol effect and protecting the liver is remarkable, the production process is mature, the mass production is facilitated, and the market application prospect is wide.