The invention discloses a preparation method of high-temperature-resistant asphalt concrete. The preparation method comprises the following steps: 1. pouring matrix asphalt into a reactor, heating thereactor to 300-320DEG C, then adding perfluoroelastomer rubber, hydrogenated acrylonitrile butadiene rubber, boron-silicon rubber, gum-based ester rubber and SBS thermoplastic elastomer, and stirringand reacting; 2. cooling the interior of the reactor to 200-220DEG C, adding furfural, asbestos powder, zinc oxide, silicon nitride, chromium carbide, aluminum-plated glass beads, calcium sulphate whisker powder and chlorinated paraffin, and stirring and reacting; 3. pouring the mixture, obtained in the step 2, into an ultrasonic dispersing machine, then adding composite resin, xylene, zinc naphthenate, Barium petroleum sulfonate, kerosene, lauroyl diethanolamine and promoter, and performing ultrasonic dispersion; and 4. shearing and dispersing the mixture, obtained in the step 3, stopping and then stirring for 30-50minutes at 150-160DEG C to obtain the high-temperature-resistant asphalt concrete.