The invention relates to organic-inorganic biological mineral composition composite synusiologic fertilizer and the preparation method thereof. The invention comprises the raw materials as follow in weight proportion: 20 to 30 parts of organic raw material, 30 to 60 parts of inorganic fertilizer, 10 to 20 parts of mineral composition raw material, and 1 to 5 parts of synusiologic mushroom. The invention has the advantages of promoting the absorption of crops, increasing the fertilizer absorption rate from primary 34 percent to more than 60 percent, decreasing the fertilizer residue, promoting the growth of the crops, improving the quality of the crops, ensuring the early development of the crops, the rich branching roots, the rich branches, the rich leaves, and early mature, and increasing the yield by 50 to 80 percent. Besides, the invention also has the advantages of restraining the development of pathogenic bacteria inside the soil, decreasing the disease and the harm to the crops, improving the structure of the soil, activating the nutrient of the soil and achieving the synusiologic planting.