The invention discloses a total knee joint replacement prosthesis, which comprises femoral condyle, tibial support, tibial pad and patella. Position column and glenoid, the glenoid defines the shape of the glenoid surface to match the articular surface of the femoral condyle, the lower end surface of the tibial pad is formed with a first groove and a second groove, and the tibial tray includes a support plate with a fixing member, The upper surface of the support plate has a first pillar and a second pillar locked with the tibial pad, and the patella includes a patella articular surface and a patella fixing post. The total knee replacement prosthesis of the present invention has good initial stability and long-term use stability, improves biocompatibility, is beneficial to bone metabolism, improves tibial support anti-subsidence, anti-rotational resistance and long-term use Stability, further improving the bonding force of the tibial support and the tibial pad, further prolonging the service life of the knee joint.