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Use of slim-1 in the assessment of heart failure

A technology for heart failure and use, applied in the field of a method for evaluating individual heart failure, can solve problems such as insufficient markers

Inactive Publication Date: 2010-01-13
THE GOVERNING COUNCIL OF THE UNIV OF TORONTO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0032] However, for many other aspects of diagnosis a single marker is not sufficient

Method used

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  • Use of slim-1 in the assessment of heart failure
  • Use of slim-1 in the assessment of heart failure
  • Use of slim-1 in the assessment of heart failure

Examples

Experimental program
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Embodiment Construction

[0041] In a first embodiment, the invention relates to a method of assessing heart failure in an individual comprising the steps of: a) measuring the concentration of the marker SLIM-1 in a sample obtained from the individual, b) optionally measuring in the sample a one or more other markers of heart failure, c) by comparing the concentration determined in step (a) and optionally the concentration determined in step (b) with the marker or markers determined in the control sample concentration comparison to assess heart failure.

[0042] As used herein, each of the following terms has the meaning associated with it in this section.

[0043] The article "a" as used herein refers to one or more than one (ie at least one) of the grammatical object of the article. For example, "an antibody" means one antibody or more than one antibody.

[0044] "One or more" means 1 to 50, preferably 1 to 20, also preferably 2, 3, 4, 5, 6, 7, 8, 9, 10, 12 or 15.

[0045] The term "marker" or "bi...

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Abstract

The invention relates to a method for assessing heart failure in vitro comprising the steps of measuring in a sample the concentration of the marker SLIM-1, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing the concentration determined in for SLIM-1 and the concentration(s) determined for the optionally one or more other marker to the concentration of this marker or these markers as established in a reference population. Also disclosed are the use of SLIM-1 as a marker protein in the assessment of heart failure, a marker combination comprising SLIM-1 and a kit for measuring SLIM-1.

Description

field of invention [0001] The present invention relates to a method of assessing heart failure in an individual comprising the steps of: a) measuring the concentration of the marker SLIM-1 in a sample obtained from the individual, b) optionally measuring one or more other heart failure symptoms in the sample and assessing heart failure by comparing the concentration determined in step (a) and optionally the concentration determined in step (b) with the concentration of the marker or markers established in a control sample. In addition, it also discloses the use of SLIM-1 as a marker protein in evaluating heart failure, including a marker combination of SLIM-1, and a kit for measuring SLIM-1. Background of the invention [0002] Heart failure (HF) is a major and growing public health problem. For example, in the United States, approximately 5 million patients suffer from HF and more than 550,000 patients are diagnosed with HF for the first time each year (cited in American H...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50G01N33/53
CPCG01N33/6887G01N2800/325
Inventor U·-H·韦恩休斯-塞伦D·布洛克A·厄米利V·方A·格拉莫利尼G·赫斯H·休迪格R·伊瑟林T·基斯林杰P·刘D·麦克伦南H·冯德埃尔茨U·－H·韦恩休斯－塞伦
Owner THE GOVERNING COUNCIL OF THE UNIV OF TORONTO
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