Diagnosis of sepsis or SIRS using biomarker profiles

A technology of biomarkers and sepsis, applied in the diagnosis of systemic inflammatory response syndrome in individuals, diagnosis or prediction of sepsis in individuals or its development stage, can solve the problem of not predicting the development of sepsis, and achieve rapid and sensitive The effect of prediction and diagnosis
CN1738908AInactive Publication Date: 2006-02-22BECTON DICKINSON & CO
1 Cites 9 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BECTON DICKINSON & CO
Publication Date
2006-02-22
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished using a molecular diagnostics approach, involving comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis. Further, because the biomarker expression is assayed for its profile, identification of the particular biomarkers is unnecessary. The comparison of an individual's biomarker profile to biomarker profiles of appropriate reference populations likewise can be used to diagnose SIRS in the individual.
Need to check novelty before this filing date? Find Prior Art

Description

[0001] This application claims priority to U.S. Provisional Patent Application Serial No. 60 / 425,322, filed November 12, 2002, and U.S. Provisional Patent Application Serial No. 60 / 503,548, filed September 17, 2003, both U.S. Provisional Patent Applications are incorporated herein by reference in their entirety. field of invention

[0002] The present invention relates to methods of diagnosing or predicting sepsis or the stages of its development in an individual. The invention also relates to methods of diagnosing systemic inflammatory response syndrome in an individual. Background of the invention

[0003] Early detection of a disease state often allows for more effective therapeutic treatment and correspondingly more favorable clinical outcomes. In many cases, however, early detection of disease symptoms is problematic; therefore, the disease may become relatively advanced before diagnosis is possible. Systemic inflammatory disorders represent one class of such diseases...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More