Taxine kind anti-cancer slow release injection

Abstract

The invention relates to a slow-release injection of taxine anti-cancer drug, which comprises anti-cancer drug, slow-release finding, suspension and / or solvent. Wherein, said anti-cancer drug is taxine, 2'-hydroxy Paclitaxel, etc; the slow-release finding is polymer of hydroxyl, glycollic acid and glycolic acid, one of acetic acid ethyenyl ester polymer and polyphony; the suspension is polyphenyl (sodium), and mannite; the solvent is distilled water, injection water, absolute ethyl alcohol, etc. The invention can be injected to reduce the toxicity effect of drug, and improve the density locally to strengthen the treatment effect of chemotherapy and radiation therapy.

Description

(1) Technical field

[0001] The invention relates to a slow-release injection containing taxine anticancer drugs, which belongs to the technical field of medicines. (2) Background technology

[0002] As commonly used chemotherapeutic drugs, taxane anticancer drugs have been widely used in the treatment of various malignant tumors, and have achieved relatively obvious effects. However, further studies have found that there are still many problems in the treatment of various malignant tumors, especially solid tumors. Solid tumors have excessive expansive hyperplasia, and the interstitial pressure, tissue elastic pressure, fluid pressure, and interstitial viscosity are all higher than those of the surrounding normal tissue. Therefore, it is difficult for conventional chemotherapy to form an effective drug concentration in the tumor. See Kong Qingzhong et al. "Intratumoral placement of cisplatin plus systemic carmustine in the treatment of brain tumors in rats" "Journal of Surgi...