40results about How to "Increase local drug concentration" patented technology

A clinical minimally-invasive intervening type medicine feeding medical device comprises a guiding catheter and a catheter connecting piece. The guiding catheter comprises a catheter body and a guiding wire. The far end of the catheter body is suitable for being implanted into a human body. The catheter connecting piece at least comprises a fixing fin and a connector which are connected in sequence from the far end to the near end. The fixing fin is provided with a fin pipe. The catheter body is inserted in from the far end of the fin pipe of the fixing fin and penetrates out from the near end of the connector. Accordingly, medicine injected from the near end of the catheter body can reach the far end of the catheter body, and then the medicine reaches a human part which needs injection. According to the intervening type medicine feeding medical device, interventional therapy can be carried out conveniently and easily, the medicine can directly reach a focus, local medicine is high in concentration, clinical effect is obviously improved, the device can be used for curing diseases such as all kinds of prostatitis and hematospermia (cystospermitis) and can also be used for seminiferous duct radiography, and accordingly diagnosis on seminiferous duct diseases can be made.

The invention relates to a vancomycin slow release microsphere with magnetic filed compliance and a preparation method thereof. The preparation method comprises the following steps: dissolving chitosan in organic solvent with emulsifying method, dispersing vancomycin and nanoscale ferroferric oxide magnetic powder, then slowly adding dispersing medium, and then adding surfactant, so that water and oil phase are mutually formed as one phase and surface tension is decreased; after emulsifying, adding crosslinking agent, so that chitosan crosslinks to form macromolecule and enwrap the vancomycin and ferroferric oxide magnetic powder; and finally, filtering and drying to obtain vancomycin slow release microsphere with magnetic filed compliance. After being infused to body, the microsphere can gather in local pathologic change part under guidance of outer magnetic field so as to improve local drug concentration and reach the purpose of targeted therapy of drug. The use of the vancomycin slow release microsphere with magnetic filed compliance can greatly improve the efficiency of drugs.

The invention belongs to the field of medicinal preparations, and particularly relates to lomefloxacin hydrochloride emulsifiable paste and a preparation method thereof. The lomefloxacin hydrochloride emulsifiable paste comprises the following components in part by weight: 0.5 to 5 parts of lomefloxacin hydrochloride, 6.8 to 105 parts of oil phase component, 52.01 to 165 parts of water phase component and 0.01 to 5 parts of preservative. The prepared paste can act on infected parts directly, so that local medicinal concentration is high, and adverse reaction caused by oral administration or venous administration is avoided. The lomefloxacin hydrochloride emulsifiable paste is definite in curative effect, and a process is stable and is suitable for large-scale industrial production.

The invention belongs to the field of medicine bioengineering and particularly relates to a drug composition containing glutathione (GSH) and an application of the drug composition. More particularly, the invention provides an application of reduced GSH to preparation of drugs for promoting diabetic implant bone integration, and further provides the drug composition containing GSH. The drug composition can promote diabetic implant bone integration and comprises GSH and other drugs, wherein the other drugs are preferably selected from resveratrol and/or insulin. Furthermore, the invention provides a drug preparation containing the drug composition and a preparation method of the drug preparation; the drug preparation is preferably selected from sustained-release microspheres.

The invention discloses a dasatinib nanopreparation, which consists of dasatinib, auxiliary material and additive; the dasatinib is 5 to 40 parts by weight, the auxiliary material is 30 to 80 parts by weight, the additive is 10 to 40 parts by weight, and the grain size of the dasatinib is less than 1Mu m. The invention further discloses a preparation method for the preparation. The invention optimizes the grain size and dissolubility of the nanodrug by adjusting the composition of the auxiliary material, concentration and preparation process parameters, so that the dissolubility of the drug is greatly increased, and the dissolution rate of the drug in 15 minutes reaches 91 to 94 percent; moreover, the production process is simple, the dasatinib nanopreparation can be mass-produced, methods, such as high temperature, high pressure and chemical reaction, which can easily destroy the ingredients of the drug are not needed, the process conditions are mild, and thereby industrialization is benefited.

The invention discloses a preparation method of a sustained-release medicine film. Sea buckthorn oil, glycerine, chitosan and bletilla striata are prepared into a circular medicine film, which is used for treatment for various tympanic membrane perforation, thus allowing the patients to avoid the operations, reducing the medical cost and being popularized in all levels of hospitals. The treatment cost of the tympanic membrane perforation by the medicine film is about one tenth of the operation cost, and the medicine film can promote the good healing of the tympanic membrane perforation, which can essentially replace the operation treatment. The operation treatment for the tympanic membrane perforation has high medical cost and is difficult to achieve the good healing of the tympanic membrane. The western region of China is rich in sea buckthorn resources which can maintain water and soil, green the environment, keep the ecological balance, and is in line with the policy of returning farmland to forest in the western loess plateau region of China. Thus, the development and the utilization of the sea buckthorn resources have important economic value and social significance. The research and development of the medicine film has great social and economic benefits, and promising prospects of popularization and application. The invention opens up the medicine film for the treatment for tympanic membrane perforation which is in line with the China's actual conditions.

The invention discloses a preparation method for biodegradable recombinant human tissue type plasiminogen activator which realizes targeted release under ultrasonic control and application of the activator to promotion of lysis of hematoma, etc. Specifically, the invention relates to a slow-release medicinal preparation. The slow-release medicinal preparation comprises a human tissue type plasiminogen activator t-PV, pluronic F127 and water. The invention also discloses the function of a hydrogel and a micelle carrier in controlling drug release under ultrasonic action. The pluronic recombinant human tissue type plasiminogen activator is simple to prepare, suitable for large-scale production and especially applicable to removal of hematoma in the brain and preparation of antineoplastic drugs capable of realizing targetable drug delivery.

The invention discloses a traditional Chinese medicine composition for treating subacute thyroiditis, a subacute thyroiditis patch and a preparation method of the subacute thyroiditis patch. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 5-20 parts of rhizoma polygoni cuspidati, 7-30 parts of herba scutellariae barbatae, 5-20 parts of radix scutellariae, 7-30 parts of taraxacum mongolicum, 7-30 parts of herba violae, 3-12 parts of prepared frankincense, 3-12 parts of prepared myrrh and 1-6 parts of rheum officinale. The traditional Chinese medicine composition disclosed by the invention is simple in medicine flavor and low in price, and the subacute thyroiditis patch prepared from the traditional Chinese medicine composition has the characteristics of being simple, convenient, low in cost and effective. The subacute thyroiditis patch treats subacute thyroiditis through external application of Chinese medicine, and can intervene and control the illness state in the early stage, shorten the disease course, improve prognosis and reduce adverse reactions of the digestive tract; and compared with western medicines, the subacute thyroiditis patch is free of obvious toxic or side effect, is easily accepted by patients and has good compliance. The subacute thyroiditis patch marks a breakthrough in both the dosage and the administration mode, providing theoretical and clinical bases for external treatment of subacute thyroiditis through traditional Chinese medicine.

The invention relates to a recombinant human interferon alpha2a suppository and a preparation method thereof. Wherein the recombinant human interferon alpha2a is obtained by the following steps: utilizing an escherichia coli expression technology to construct a recombinant plasmid containing a human interferon alpha2a gene, and transforming into escherichia coli to obtain a stable engineering bacterium, fermenting the engineering bacterium, and purifying the engineering bacterium to obtain recombinant human interferon alpha2a, through sterile filtration, and mixing with glycerol and a gelatinmatrix, the recombinant human interferon alpha2a suppository is obtained. The formula of the matrix is characterized in that the matrix does not contain human serum albumin, wherein glycerol is not only an excipient, but also a bacteriostatic agent; the gelatin is also an excipient or a protease inhibitor, can effectively protect the protein of the recombinant human interferon alpha2a from being degraded, ensures the structural integrity of the recombinant human interferon alpha2a, stabilizes the biological activity of the interferon, can interfere with protease released by cells to further destroy damaged mucous membrane tissues of the vagina, and has a mucous membrane protection effect.

The present invention provides an application of sinomenine hydrochloride to the preparation of a drug for treating pain caused by rib fracture. The sinomenine hydrochloride may be used for preparingthe drug for treating pain caused by rib fracture. Compared with an opioid drug, a general anesthesia drug and a non-steroidal pain relieving drug, the sinomenine hydrochloride provided by the presentapplication has fewer adverse reactions. Compared with a method such as an intravenous injection method or a whole-body oral administration method, a local ashi-point injection method is higher in local drug concentration and better in pain relieving effect; and the sinomenine hydrochloride has a better treatment effect clinically in combination with an acupoint effect while taking a drug effect.The sinomenine hydrochloride provided by the present application is simple and convenient to operate due to no need of help from other people or equipment and instruments during treatment.