40results about How to "Increase local drug concentration" patented technology

A tumescent composition including a cannabinoid dissolved in a tumescent solution, wherein the tumescent solution includes a local anesthetic; a vasoconstrictor; and a pharmaceutically acceptable carrier, wherein a tumescent concentration of the cannabinoid is 1-2000 μg / kg and is simultaneously: below a threshold for local, subcutaneous tissue toxicity, above a threshold for positive local therapeutic effect, and above a concentration safely achievable by intravenous (IV), intramuscular (IM) or oral (PO) delivery. Also disclosed are methods of subcutaneous delivery of a cannabinoid to a subject including administering to the subject the tumescent composition.

The invention relates to a ketoprofen transdermal patch and a preparation method thereof. The ketoprofen transdermal patch comprises a backing layer, a drug-containing colloid layer and an anti-sticking layer, wherein the drug-containing colloid layer comprises ketoprofen, a humectant, an absorption enhancer, a colloid matrix material and an additive. The ketoprofen transdermal patch can improve the local drug concentration of a pain part, can regulate an administration dosage through control of an administration area, can interrupt administration at any time, is convenient in use, and improves the compliance of medication. The ketoprofen transdermal patch has a high drug loading capacity and a good transdermal absorption effect, is small in skin irritation, is free from allergy-prone components, is free from pollution; is good in breathability, is good in skin fitting performance, can be easily peeled off, does not have peculiar smells, does not have skin irritation or anaphylactic reaction, is high in safety, has a simple preparation technology, is easy in implementation, is good in stability, is used for treating rheumatism / rheumatic arthritis and has a good clinical effect.

Disclosed are methods of subcutaneous delivery of a drug or a therapeutic agent to a subject comprising administering to said subject a tumescent composition comprising: (a) the drug or the therapeutic agent, wherein a tumescent concentration of the drug is simultaneously: 1) below a threshold for local, subcutaneous tissue toxicity, 2) above a threshold for positive local therapeutic effect, and 3) above a concentration achievable by intravenous (IV), intramuscular (IM) or oral (PO) delivery; (b) a vasoconstrictor; and (c) a pharmaceutically acceptable carrier. Some embodiments relate to a method of treating or preventing sepsis or Systemic Inflammatory Response Syndrome (SIRS) in a subject. Some embodiments relate to a tumescent solution for treating a localized viral infection, e.g., varicella-zoster (shingles), the tumescent solution comprising an antiviral agent.

The invention provides externally applied traditional Chinese medicine combination for treating chronic pelvic inflammatory disease through applying iontophoresis and a preparation method. The externally applied traditional Chinese medicine combination is prepared by the following raw materials in parts by weight: 45-55 parts of sargent gloryvine, 35-45 parts of dandelion, 35-45 parts of honeysuckle, 15-25 parts of poria cocos, 25-35 parts of cassia twig, 15-25 parts of rhizoma zingiberis, 25-35 parts of peach kernel, 15-25 parts of safflower carthamus, 35-45 parts of salvia miltiorrhiza, 25-35 parts of red peony root, 25-35 parts of leonurus, 15-25 parts of manis pentadactyla, 35-45 parts of sparganii, 35-45 parts of curcuma zedoary, 25-35 parts of herba lycopi, 25-35 parts of ligusticum wallichii, 25-35 parts of corydalis tuber and 15-25 parts of liquorice. The preparation method comprises the following steps of: firstly crushing the manis pentadactyla; mixing the crushed manis pentadactyla and other traditional Chinese medicines; soaking by fresh water for 35-45 minutes, boiling through high heat; decocting for 25-35 minutes through slow fire; decocting for two times; and refrigerating for standby after mixing, concentrating and filtering the medicines. The externally applied traditional Chinese medicine combination for treating the chronic pelvic inflammatory disease through applying the iontophoresis has the advantages of high cure rate, good curative effect, low treatment expense and little side effect.

The invention belongs to the field of pharmaceutical preparations and particularly relates to a moxifloxacin hydrochloride external preparation and a preparation method thereof. The external preparation specifically refers to a cream and comprises a combination of a skin penetration enhancer comprising N-trimethyl chitosan, menthol and isopropyl myristate, the external preparation can be directly acted on an infection part, the gastric and intestinal irritation caused by oral administration is avoided, and the skin is not irritated either. The cream further greatly improves the skin penetration rate of a medicine, so that the local absorption is fast, and the treatment effect is remarkable. To further enhance the anti-inflammatory and anti-allergic effects, a non-steroidal anti-inflammatory drug, namely butyl flufenamate, is further added in the cream. The preparation process of the cream is simple and feasible, is high in reproducibility, and is suitable for industrial production.

The invention discloses a dasatinib nanopreparation, which consists of dasatinib, auxiliary material and additive; the dasatinib is 5 to 40 parts by weight, the auxiliary material is 30 to 80 parts by weight, the additive is 10 to 40 parts by weight, and the grain size of the dasatinib is less than 1Mu m. The invention further discloses a preparation method for the preparation. The invention optimizes the grain size and dissolubility of the nanodrug by adjusting the composition of the auxiliary material, concentration and preparation process parameters, so that the dissolubility of the drug is greatly increased, and the dissolution rate of the drug in 15 minutes reaches 91 to 94 percent; moreover, the production process is simple, the dasatinib nanopreparation can be mass-produced, methods, such as high temperature, high pressure and chemical reaction, which can easily destroy the ingredients of the drug are not needed, the process conditions are mild, and thereby industrialization is benefited.

The invention discloses a traditional Chinese medicine aerosol for treatment of infantile cough. According to traditional Chinese medical science, etiological factors of infantile cough include phlegm-heat accumulation, exterior disorder, interior and exterior inharmony, phlegm stagnation in air ways and failure of lung qi in dispersion. Therefore, traditional Chinese medicines including pyrrosialeaf, polygonum cuspidatum, citron fruit, angelica dahurica, fistular onion stalk, folium mori and amomum cardamomum, which have functions of freeing lung and relieving asthma, clearing lung heat, and eliminating phlegm and relieving a cough, are used for preparing the aerosol in the drug manufacturing room of the people's hospital of Yinan county. According to clinical tests in the people's hospital of Yinan county, the total effective rate reaches 97.3% which is evidently higher than control groups. The traditional Chinese medicine aerosol is externally and locally applied, high in medicineutilization rate, low in toxic and adverse effect, convenient in use, quick in effectiveness and worthy of clinical popularization and application.

A suppository of terbinafine hydrochloride for treating the fungus infection of woman's reproduction tract is prepared from terbinafine hydrochloride, matrix and dissolving promoter. Its preparing process is also disclosed.

The invention discloses sodium azulene sulfonate gel. The sodium azulene sulfonate gel is prepared from 0.05-1 weight part of sodium azulene sulfonate, 0.5-50 weight parts of a gel base material, 1-50 weight parts of a transdermal enhancer, 0.5-2.5 weight parts of a pH conditioning agent, 0.1-0.5 weight parts of an antiseptic and 40-65 weight parts of a solvent. The invention also provides a preparation method and a use of the sodium azulene sulfonate gel. The sodium azulene sulfonate gel has the advantages of good appearance, good coating performances, use convenience, good biocompatibility with skin, no irritation and no pollution on clothes, and has strong skin adhesion, good permeability and a high concentration on local skin.