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Vancomycin slow release microsphere with magnetic filed compliance and preparation method thereof

A technology of vancomycin, slow-release microspheres, applied in the field of chemistry, to achieve the effect of high local drug concentration

Inactive Publication Date: 2010-06-02
王文
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This preparation technology has not been reported at home and abroad

Method used

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  • Vancomycin slow release microsphere with magnetic filed compliance and preparation method thereof
  • Vancomycin slow release microsphere with magnetic filed compliance and preparation method thereof
  • Vancomycin slow release microsphere with magnetic filed compliance and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 Preparation of vancomycin sustained-release microspheres with magnetic field compliance

[0050] (1) preparation of chitosan acetic acid solution

[0051] 1g chitosan is dissolved in 1% acetic acid solution 100ml, is made into the chitosan acetic acid solution of 1% (g / g) concentration;

[0052] (2) Preparation of aqueous phase liquid

[0053] Nanoscale iron ferric oxide 0.1g and vancomycin 0.1g are dissolved in the chitosan acetic acid solution that 20ml step (1) makes to obtain aqueous phase liquid;

[0054] (3) Preparation of oil phase liquid

[0055] Add 80ml of ethyl benzoate to 1ml of Span-80 to obtain an oil phase liquid;

[0056] (4) Preparation of emulsion

[0057] Add the water phase liquid prepared in step (2) into the oil phase prepared in step (3) for emulsification to obtain an emulsified liquid. The emulsification conditions are: temperature 20°C, stirring speed 500 rpm, emulsification time 20 min;

[0058] (5) Formation of microspheres

[0...

Embodiment 2

[0062] Example 2 Preparation of vancomycin sustained-release microspheres with magnetic field compliance

[0063] (1) preparation of chitosan acetic acid solution

[0064] 1g chitosan is dissolved in 2% acetic acid solution 100ml, is made into the chitosan acetic acid solution of 1% (g / g) concentration;

[0065] (2) Preparation of aqueous phase liquid

[0066] Nanoscale iron ferric oxide 0.2g and vancomycin 0.1g are dissolved in the chitosan acetic acid solution that 20ml step (1) makes to obtain aqueous phase liquid;

[0067] (3) Preparation of oil phase liquid

[0068] Add 100ml of ethyl benzoate to 2ml of Span-80 to obtain an oil phase liquid;

[0069] (4) Preparation of emulsion

[0070] Add the water phase liquid prepared in step (2) into the oil phase prepared in step (3) to emulsify to obtain an emulsified liquid. The emulsification conditions are: temperature 30°C, stirring speed 1000rpm, emulsification time 30min;

[0071] (5) Formation of microspheres

[0072] ...

Embodiment 3

[0075] Example 3 Preparation of vancomycin sustained-release microspheres with magnetic field compliance

[0076] (1) preparation of chitosan acetic acid solution

[0077] 1g chitosan is dissolved in 2% acetic acid solution 100ml, is made into the chitosan acetic acid solution of 1% (g / g) concentration;

[0078] (2) Preparation of aqueous phase liquid

[0079] Nanoscale iron ferric oxide 0.2g and vancomycin 0.2g are dissolved in the chitosan acetic acid solution that 20ml step (1) makes to obtain aqueous phase liquid;

[0080] (3) Preparation of oil phase liquid

[0081] Add 60ml of ethyl benzoate to 2ml of Span 80 to obtain an oil phase liquid;

[0082] (4) Preparation of emulsion

[0083] Add the water phase liquid prepared in step (2) into the oil phase prepared in step (3) to emulsify to obtain an emulsified liquid. The emulsification conditions are: temperature 40°C, stirring speed 1500rpm, emulsification time 30min;

[0084] (5) Formation of microspheres

[0085] A...

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Abstract

The invention relates to a vancomycin slow release microsphere with magnetic filed compliance and a preparation method thereof. The preparation method comprises the following steps: dissolving chitosan in organic solvent with emulsifying method, dispersing vancomycin and nanoscale ferroferric oxide magnetic powder, then slowly adding dispersing medium, and then adding surfactant, so that water and oil phase are mutually formed as one phase and surface tension is decreased; after emulsifying, adding crosslinking agent, so that chitosan crosslinks to form macromolecule and enwrap the vancomycin and ferroferric oxide magnetic powder; and finally, filtering and drying to obtain vancomycin slow release microsphere with magnetic filed compliance. After being infused to body, the microsphere can gather in local pathologic change part under guidance of outer magnetic field so as to improve local drug concentration and reach the purpose of targeted therapy of drug. The use of the vancomycin slow release microsphere with magnetic filed compliance can greatly improve the efficiency of drugs.

Description

technical field [0001] The invention relates to a drug microsphere and a preparation method thereof, belonging to the technical field of chemistry. Background technique [0002] Vancomycin is an antibiotic with the molecular formula C 66 h 74 C 1 N 9 o 24 . Its half-life is 4-8 hours, renal failure is 9 days, it is ineffective against anaerobic and Gram-negative bacteria, and hemodialysis will not remove vancomycin. [0003] Vancomycin is powerful and nephrotoxic. It is used only when other antibiotics are ineffective against bacteria. It is the so-called last-line drug. In recent years, due to excessive abuse of antibiotics, bacteria resistant to vancomycin have emerged, such as vancomycin-resistant enterococci (VRE), causing hidden concerns in the prevention and control of infectious diseases. [0004] Vancomycin kills bacteria by inhibiting their growth and reproduction. The drug interferes with cell wall synthesis by interfering with a key component of bacterial ...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K38/14A61K47/04A61K47/36A61P1/00A61P31/04
Inventor 王文蔡锦方曹学成王健
Owner 王文
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