A kind of olopatadine hydrochloride external composition and its cream
A technology of olopatadine hydrochloride and topical composition, which is applied in the field of topical composition and its preparation, can solve problems such as adverse reactions, and achieve the effects of simple and easy preparation process, convenient carrying, and reduced adverse reactions
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0035] An olopatadine hydrochloride cream, which comprises the following components in parts by weight: olopatadine hydrochloride 0.3, white petrolatum 7.0, cetyl alcohol 7.0, liquid paraffin 3.0, glyceryl monostearate 3.0, triethanolamine 0.5, Tween-802.0, glycerin 8.0, ethylparaben 0.1, water-soluble azone 1.0, purified water 68.2.
[0036] The preparation method of above-mentioned olopatadine hydrochloride cream:
[0037] (1) Melt and mix white petrolatum, cetyl alcohol, liquid paraffin and glyceryl monostearate at 60-80° C. as the oil phase;
[0038] (2) Dissolving the olopatadine hydrochloride of the formula quantity in the water of the formula quantity, adjusting the pH value to neutrality with the triethanolamine of the formula quantity, then adding Tween-80, water-soluble azone, Glycerin, ethylparaben, heated to 60°C to dissolve and mix well, as the water phase;
[0039] (3) Pour the water phase into the oil phase at 60-℃, stir while pouring, and cool to obtain.
Embodiment 2
[0041] An olopatadine hydrochloride cream, which comprises the following components in parts by weight: olopatadine hydrochloride 1.0, white petrolatum 8.0, cetyl alcohol 6.0, liquid paraffin 2.0, glyceryl monostearate 4.0, triethanolamine 0.55, Tween-800.5, glycerin 10.0, ethylparaben 0.05, diethylene glycol monoethyl ether 5.0, purified water 62.9.
[0042] The preparation method of above-mentioned olopatadine hydrochloride cream:
[0043] (1) Melt and mix white petrolatum, cetyl alcohol, liquid paraffin and glyceryl monostearate at 60-80° C. as the oil phase;
[0044] (2) Dissolving the olopatadine hydrochloride of the formula quantity in the water of the formula quantity, adjusting the pH value to neutrality with the triethanolamine of the formula quantity, then adding Tween-80, water-soluble azone, Glycerin, ethylparaben, heated to 80°C to dissolve and mix well, as the water phase;
[0045] (3) Pour the water phase into the oil phase at 80°C, stir while pouring, and coo...
Embodiment 3
[0047] An olopatadine hydrochloride cream, which comprises the following components in parts by weight: olopatadine hydrochloride 2.0, white petrolatum 10.0, cetyl alcohol 5.0, liquid paraffin 1.0, glyceryl monostearate 2.0, triethanolamine 0.45, sodium lauryl sulfate 1.0%, glycerin 10.0, ethylparaben 0.05, disodium ethylenediaminetetraacetic acid (EDTA-2Na) 2.0, purified water 67.5.
[0048] The preparation method of above-mentioned olopatadine hydrochloride cream:
[0049] (1) Melt and mix white petrolatum, cetyl alcohol, liquid paraffin and glyceryl monostearate at 60-80° C. as the oil phase;
[0050] (2) Dissolving the olopatadine hydrochloride of the formula quantity in the water of the formula quantity, adjusting the pH value to neutrality with the triethanolamine of the formula quantity, then adding Tween-80, water-soluble azone, Glycerin, ethylparaben, heated to 70°C to dissolve and mix well, as the water phase;
[0051] (3) Pour the water phase into the oil phase at 7...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com