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Preparation of sustained-release medical membrane

A drug film and slow-release technology, which is applied in the field of medicine and drug film, can solve the problems of expensive drugs, no experimental research, poor scientificity, etc., and achieve the effect of promoting benign healing, convenient use, and long acting time

Inactive Publication Date: 2008-11-05
赵存录
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs are expensive and inconvenient to use, so it is difficult to promote their use in our country
Domestic scholars use urea, egg skin, and Chinese herbal medicine to treat tympanic membrane perforation. Because there is no control group, there is no experimental research, and the scientific quality is poor.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] The preparation method of the above-mentioned 4% bletilla striata powder glue and 5% chitosan solution is carried out according to "China Pharmaceutical Industry Journal" "Research and development of chitosan-Bletilla striata glue drug-loaded film" (Miao Jing, Song Zhengji, Jiang Wei, Xue Chunlan, Cao Haiyan, etc. , 2000.31(6) No.263~271).

[0025] 2) Mix 60ml of spare 4% chitosan with 20ml of 5% bletilla striata gum, add 15ml of seabuckthorn oil and 5ml of glycerin, heat in a water bath at 85°C for 20min, stir well, remove air bubbles, cool and place until all bubbles disappear, and put the mixture Pour it onto a glass plate pre-coated with paraffin, and spread it into a uniform thin film of 0.6mm±0.1mm. After natural drying at room temperature for 24h-48h, divide it into circular medicine films with a diameter of 0.5cm-0.8cm, put them in small plastic bags, and irradiate them with ultraviolet rays for 30 minutes.

[0026] Sustained-release drug film is currently the ...

specific example

[0030] At present, 35 cases of tympanic membrane perforation have been treated with tympanic membrane rehabilitation slow-release medicine membrane, and the curative effect is remarkable. Among the 25 cases of traumatic tympanic membrane perforation, the healing rate of large perforation was 90%; the healing rate of small and medium perforation was 98%. The average medication was 2-6 times. There were 10 cases of otitis media perforation, and the healing rate of perforation was 85%; the medicine was applied 12 to 24 times on average. It can basically replace tympanoplasty, and the slow-release drug membrane for treating tympanic membrane perforation of the present invention saves patients from the suffering of surgery, reduces medical expenses, and saves medical expenses for the country. It can be promoted and used in hospitals at all levels.

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Abstract

The invention discloses a preparation method of a sustained-release medicine film. Sea buckthorn oil, glycerine, chitosan and bletilla striata are prepared into a circular medicine film, which is used for treatment for various tympanic membrane perforation, thus allowing the patients to avoid the operations, reducing the medical cost and being popularized in all levels of hospitals. The treatment cost of the tympanic membrane perforation by the medicine film is about one tenth of the operation cost, and the medicine film can promote the good healing of the tympanic membrane perforation, which can essentially replace the operation treatment. The operation treatment for the tympanic membrane perforation has high medical cost and is difficult to achieve the good healing of the tympanic membrane. The western region of China is rich in sea buckthorn resources which can maintain water and soil, green the environment, keep the ecological balance, and is in line with the policy of returning farmland to forest in the western loess plateau region of China. Thus, the development and the utilization of the sea buckthorn resources have important economic value and social significance. The research and development of the medicine film has great social and economic benefits, and promising prospects of popularization and application. The invention opens up the medicine film for the treatment for tympanic membrane perforation which is in line with the China's actual conditions.

Description

technical field [0001] The invention belongs to medicine, relates to a medicine film, in particular to a preparation method of a slow-release medicine film for treating tympanic membrane perforation. Background technique [0002] Tympanic membrane perforation is a common and frequently-occurring disease in otolaryngology, which often leads to tinnitus, ear fullness, and hearing loss in patients, and is one of the main causes of deafness. Tympanic membrane perforation is one of the main causes of deafness, and active and effective treatment measures are of great significance in the work of preventing and treating deafness. Conventional treatment is anti-infection, waiting for self-healing. Usually, some tympanic membrane perforations can heal by themselves, but most tympanic membrane perforations form scars or seal the perforation with a thin epithelial layer and affect hearing. 1-3 months before the perforation has not healed, the tympanic membrane can be repaired. Due to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/70A61K47/36A61P27/16
Inventor 赵存录
Owner 赵存录
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