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A kind of external preparation of moxifloxacin hydrochloride and preparation method thereof

A technology of moxifloxacin hydrochloride and ointment, which is applied in the field of external preparations of moxifloxacin hydrochloride, can solve the problems of low osmotic concentration and inability to play a full role, and achieves the effects of rapid penetration and absorption, promotion of wound healing, and promotion of transport.

Active Publication Date: 2018-01-05
NANJING YOUKE BIOLOGICAL MEDICAL RES +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although injection or oral administration of moxifloxacin has good tissue mobility, its penetration concentration in some affected areas is low, so systemic administration is difficult to ensure that the drug only acts on the infected area and cannot fully exert its effect, and its side effects are harmful to children. , infants, pregnant women, and patients who cannot tolerate these drugs should use topical treatment

Method used

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  • A kind of external preparation of moxifloxacin hydrochloride and preparation method thereof
  • A kind of external preparation of moxifloxacin hydrochloride and preparation method thereof
  • A kind of external preparation of moxifloxacin hydrochloride and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The prescription is as follows:

[0042] Moxifloxacin Hydrochloride 0.5%

[0043] Stearic Acid 30%

[0044] Glyceryl Monostearate 15%

[0045] White Vaseline 10%

[0046] Lanolin 12%

[0047] Glycerin 8%

[0048] Ethylparaben 0.06%

[0049] Edetate Disodium 0.05%

[0050] Triethanolamine 4%

[0051] N-Trimethyl Chitosan 3%

[0052] Menthol 2%

[0053] Isopropyl myristate 1%

[0054] Purified water balance.

[0055] Preparation method: The following materials are fed according to the prescription quantity

[0056] 1) Heat stearic acid, glyceryl monostearate, lanolin, and white petrolatum to 75-80°C and mix well to obtain the oil phase;

[0057] 2) First put N-trimethyl chitosan into 75% of the prescription amount of purified water, stir until it is completely dissolved, then add menthol, after stirring evenly, add disodium edetate, ethylparaben, and triethanolamine in sequence , heated to 75-80°C and stirred evenly to obtain an aqueous phase;

[0058] 3) Ad...

Embodiment 2

[0061] The prescription is as follows:

[0062] Moxifloxacin Hydrochloride 0.8%

[0063] Stearic Acid 20%

[0064] Glyceryl Monostearate 10%

[0065] White Vaseline 8%

[0066] Lanolin 10%

[0067] Glycerin 6%

[0068] Chlorobutanol 0.04%

[0069] Edetate Disodium 0.05%

[0070] Triethanolamine 3%

[0071] N-Trimethyl Chitosan 3%

[0072] Menthol 2%

[0073] Isopropyl myristate 1%

[0074] Purified water balance.

[0075] Preparation method: The following materials are fed according to the prescription quantity

[0076] 1) Heat stearic acid, glyceryl monostearate, lanolin, and white petrolatum to 75-80°C and mix well to obtain the oil phase;

[0077] 2) First put N-trimethyl chitosan into 75% of the prescription amount of purified water, stir until completely dissolved, then add menthol, stir well, then add disodium edetate, chlorobutanol, triethanolamine in turn , heated to 75-80°C and stirred evenly to obtain an aqueous phase;

[0078] 3) Add the water phase to...

Embodiment 3

[0081] The prescription is as follows:

[0082] Moxifloxacin Hydrochloride 0.5%

[0083] Butyl flufenamate 0.1%

[0084] Stearic Acid 20%

[0085] Glyceryl Monostearate 10%

[0086] White Vaseline 8%

[0087] Lanolin 10%

[0088] Glycerin 6%

[0089] Ethylparaben 0.04%

[0090] Edetate Disodium 0.05%

[0091] Triethanolamine 3%

[0092] N-Trimethyl Chitosan 3%

[0093] Menthol 2%

[0094] Isopropyl myristate 1%

[0095] Purified water balance.

[0096] Preparation method: The following materials are fed according to the prescription quantity

[0097] 1) Heat stearic acid, glyceryl monostearate, lanolin, and white petrolatum to 75-80°C and mix well to obtain the oil phase;

[0098] 2) First put N-trimethyl chitosan into 75% of the prescription amount of purified water, stir until it is completely dissolved, then add menthol, after stirring evenly, add disodium edetate, ethylparaben, and triethanolamine in sequence , heated to 75-80°C and stirred evenly to obtain a...

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Abstract

The invention belongs to the field of pharmaceutical preparations and particularly relates to a moxifloxacin hydrochloride external preparation and a preparation method thereof. The external preparation specifically refers to a cream and comprises a combination of a skin penetration enhancer comprising N-trimethyl chitosan, menthol and isopropyl myristate, the external preparation can be directly acted on an infection part, the gastric and intestinal irritation caused by oral administration is avoided, and the skin is not irritated either. The cream further greatly improves the skin penetration rate of a medicine, so that the local absorption is fast, and the treatment effect is remarkable. To further enhance the anti-inflammatory and anti-allergic effects, a non-steroidal anti-inflammatory drug, namely butyl flufenamate, is further added in the cream. The preparation process of the cream is simple and feasible, is high in reproducibility, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to an external preparation of moxifloxacin hydrochloride and a preparation process thereof. Background technique [0002] Moxifloxacin is the fourth-generation fluoroquinolone antibacterial drug listed by Bayer AG in Germany in the late 1990s. Since its listing, moxifloxacin has the advantages of broad antibacterial spectrum, strong antibacterial power, wide distribution in the body, high drug concentration in the body, long half-life, good curative effect, small side effects, no cross-resistance with other antibacterial drugs, and almost no photosensitivity reaction. , has been widely used clinically. In recent years, studies have found that moxifloxacin has high early bactericidal activity, low anti-mutation concentration, low drug resistance selection index, good tissue penetration, and easy accumulation in respiratory mucosa and lung tissue. Its therapeuti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/4709A61K47/36A61K47/10A61K47/14A61P31/04
Inventor 闵涛朱素华薛峪泉徐晓霞张峰胡玉琴
Owner NANJING YOUKE BIOLOGICAL MEDICAL RES
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