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Sodium azulene sulfonate gel and its preparation method and use

A technology of sodium azulene sulfonate and gel, applied in the field of sodium azulene sulfonate gel and preparation thereof, can solve problems such as gastrointestinal irritation, side effects, etc., and achieve high drug concentration, good stability, and coatability Good results

Active Publication Date: 2013-11-20
SICHUAN GUOKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, after long-term oral use of this kind of drug, it will show systemic side effects, especially side effects such as stimulation of the gastrointestinal tract.

Method used

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  • Sodium azulene sulfonate gel and its preparation method and use
  • Sodium azulene sulfonate gel and its preparation method and use
  • Sodium azulene sulfonate gel and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0033] Remove the raw and auxiliary materials of the formula ratios in the table below, and prepare them with reference to the conventional preparation process of the gel, for example:

[0034] Preparation method 1: crush sodium azulene sulfonate through an 80-mesh sieve and mix it evenly with the gel base to obtain a mixture of sodium azulene sulfonate and gel base; In the mixture of gum base; add solvent to the mixture, stir fully until fully swollen, then add transdermal accelerator and stir evenly, add PH regulator and stir evenly, make sodium azulene sulfonate gel, pack separately, that is have to.

[0035] Preparation method 2: crush sodium azulene sulfonate through an 80-mesh sieve, dissolve in an appropriate amount of solvent with a transdermal accelerator, preservative and gel matrix, fully swell, add the remaining solvent, and stir evenly to form sodium azulene sulfonate Gel, packaged separately, ready to use.

[0036] Table 1

[0037]

[0038] The beneficial e...

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PUM

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Abstract

The invention discloses sodium azulene sulfonate gel. The sodium azulene sulfonate gel is prepared from 0.05-1 weight part of sodium azulene sulfonate, 0.5-50 weight parts of a gel base material, 1-50 weight parts of a transdermal enhancer, 0.5-2.5 weight parts of a pH conditioning agent, 0.1-0.5 weight parts of an antiseptic and 40-65 weight parts of a solvent. The invention also provides a preparation method and a use of the sodium azulene sulfonate gel. The sodium azulene sulfonate gel has the advantages of good appearance, good coating performances, use convenience, good biocompatibility with skin, no irritation and no pollution on clothes, and has strong skin adhesion, good permeability and a high concentration on local skin.

Description

technical field [0001] The invention relates to a sodium azulene sulfonate gel and its preparation method and application. Background technique [0002] Sodium azulene sulfonate is the abbreviation of sodium guaiazulene sulfonate, and its chemical name is 1,4-dimethyl-7-isopropylazulene-3-sodium sulfonate. Its parent compound is azulene, and guaiazulene is its alkyl substitute. There are also other derivatives of azulene with different substituents and different substitution positions. [0003] Azulene and other derivatives are non-benzene carbocyclic aromatic compounds. Although it is less aromatic than benzene-based aromatic compounds, electrophilic substitution reactions can still occur on the ring. Alkyl-substituted azulene, especially the 1, 4-methyl, 7-ethyl or isopropyl compounds have strong biological activity. Sodium azulene sulfonate has antibacterial, antiallergic and tissue regeneration functions, and has high safety, so it is widely used in various pharmaceu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/185A61K47/04A61P31/04A61P37/08A61P43/00A61P17/00
Inventor 石万棋郎天琼邓聪史成刚吴小春
Owner SICHUAN GUOKANG PHARMA
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