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Olopatadine hydrochloride containing externally applied composition and cream thereof

A technology of olopatadine hydrochloride and topical composition, which is applied in the field of topical composition and its preparation, can solve problems such as adverse reactions, and achieve the effects of simple and easy preparation process, reduced adverse reactions, and good stability

Active Publication Date: 2018-03-23
深圳博瑞医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to provide a kind of external application composition that comprises olopatadine hydrochloride for the treatment of pruritus skin disease, to solve the adverse reaction that oral administration of olopatadine hydrochloride tablet produces in the prior art

Method used

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  • Olopatadine hydrochloride containing externally applied composition and cream thereof
  • Olopatadine hydrochloride containing externally applied composition and cream thereof
  • Olopatadine hydrochloride containing externally applied composition and cream thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] An olopatadine hydrochloride cream, which comprises the following components in parts by weight: olopatadine hydrochloride 0.3, white petrolatum 7.0, cetyl alcohol 7.0, liquid paraffin 3.0, glyceryl monostearate 3.0, triethanolamine 0.5, Tween-802.0, glycerin 8.0, ethylparaben 0.1, water-soluble azone 1.0, purified water 68.2.

[0036] The preparation method of above-mentioned olopatadine hydrochloride cream:

[0037] (1) Melt and mix white petrolatum, cetyl alcohol, liquid paraffin and glyceryl monostearate at 60-80° C. as the oil phase;

[0038] (2) Dissolving the olopatadine hydrochloride of the formula quantity in the water of the formula quantity, adjusting the pH value to neutrality with the triethanolamine of the formula quantity, then adding Tween-80, water-soluble azone, Glycerin, ethylparaben, heated to 60°C to dissolve and mix well, as the water phase;

[0039] (3) Pour the water phase into the oil phase at 60-℃, stir while pouring, and cool to obtain.

Embodiment 2

[0041] An olopatadine hydrochloride cream, which comprises the following components in parts by weight: olopatadine hydrochloride 1.0, white petrolatum 8.0, cetyl alcohol 6.0, liquid paraffin 2.0, glyceryl monostearate 4.0, triethanolamine 0.55, Tween-800.5, glycerin 10.0, ethylparaben 0.05, diethylene glycol monoethyl ether 5.0, purified water 62.9.

[0042] The preparation method of above-mentioned olopatadine hydrochloride cream:

[0043] (1) Melt and mix white petrolatum, cetyl alcohol, liquid paraffin and glyceryl monostearate at 60-80° C. as the oil phase;

[0044] (2) Dissolving the olopatadine hydrochloride of the formula quantity in the water of the formula quantity, adjusting the pH value to neutrality with the triethanolamine of the formula quantity, then adding Tween-80, water-soluble azone, Glycerin, ethylparaben, heated to 80°C to dissolve and mix well, as the water phase;

[0045] (3) Pour the water phase into the oil phase at 80°C, stir while pouring, and coo...

Embodiment 3

[0047] An olopatadine hydrochloride cream, which comprises the following components in parts by weight: olopatadine hydrochloride 2.0, white petrolatum 10.0, cetyl alcohol 5.0, liquid paraffin 1.0, glyceryl monostearate 2.0, triethanolamine 0.45, sodium lauryl sulfate 1.0%, glycerin 10.0, ethylparaben 0.05, disodium ethylenediaminetetraacetic acid (EDTA-2Na) 2.0, purified water 67.5.

[0048] The preparation method of above-mentioned olopatadine hydrochloride cream:

[0049] (1) Melt and mix white petrolatum, cetyl alcohol, liquid paraffin and glyceryl monostearate at 60-80° C. as the oil phase;

[0050] (2) Dissolving the olopatadine hydrochloride of the formula quantity in the water of the formula quantity, adjusting the pH value to neutrality with the triethanolamine of the formula quantity, then adding Tween-80, water-soluble azone, Glycerin, ethylparaben, heated to 70°C to dissolve and mix well, as the water phase;

[0051] (3) Pour the water phase into the oil phase at 7...

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Abstract

The invention discloses an externally applied composition and a preparation thereof, in particular an olopatadine hydrochloride containing externally applied composition and cream thereof. The composition contains olopatadine hydrochloride. The olopatadine hydrochloride containing externally applied composition directly acts on an affected part, the local medicament concentration of skin at an itching part is increased, and the effects of resisting histamine and stabilizing mast cells are achieved; adverse reaction of oral administration is avoided; the administration dosage can be selected according to the area of a diseased part, and the olopatadine hydrochloride containing externally applied composition is convenient to use and carry and high in stability; efficacy tests show that the composition has remarkable treatment effects on pruritic dermatosis; a process for the cream is simple, easy and low in cost.

Description

technical field [0001] The invention relates to an external composition and its preparation, in particular to an external composition containing olopatadine hydrochloride for treating pruritus skin diseases and its cream. Background technique [0002] There are many kinds of skin diseases, and common skin diseases such as skin infections and atopic dermatitis are in the majority. It is one of common diseases and frequently-occurring diseases that seriously affect people's health. Patients have different degrees of itching, and when it is severe, it will affect work, life and physical and mental health. [0003] Olopatadine hydrochloride is an antiallergic drug developed and marketed by Japan Kyowa Hakko Co., Ltd., and has been listed in Europe, the United States, Japan and other countries successively. Olopatadine hydrochloride, as a new type of relatively selective antiallergic drug, can inhibit the release of tachykinin and other chemical transmitters, such as histamine, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/335A61K47/18A61K47/22A61K47/10A61P17/04
CPCA61K9/0014A61K9/06A61K31/335A61K47/10A61K47/183A61K47/22
Inventor 马仁强田玉婷王栋谭舜徐丽马艺华
Owner 深圳博瑞医药科技有限公司
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