Lomefloxacin hydrochloride emulsifiable paste and preparation method thereof

A technology of lomefloxacin hydrochloride and lomefloxacin cream, which is applied in the direction of ointment delivery, pharmaceutical formula, emulsion delivery, etc., can solve the problems of insufficient function and low osmotic concentration of the affected part, so as to avoid adverse reactions and drug The effect of high concentration and stable process

Inactive Publication Date: 2012-08-01
TIANJIN PHARMA GROUP XINZHENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, chemotherapy for skin and soft tissue infections uses systemic administration and topical administration at the same time. Although oral administration of lomefloxacin has excellent tissue mobility, the penetration concentration in some affected areas is low, so it is difficult to guarantee systemic administration. The drug is used only at the site of infection and does not work adequately, and because of its side effects, topical treatment is currently recommended for children, infants, pregnant women, and patients with epilepsy, convulsions, or intolerant of these drugs

Method used

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  • Lomefloxacin hydrochloride emulsifiable paste and preparation method thereof
  • Lomefloxacin hydrochloride emulsifiable paste and preparation method thereof
  • Lomefloxacin hydrochloride emulsifiable paste and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take 10.8g of stearic acid, 4.8g of glyceryl monostearate, 2.4g of liquid paraffin, 1.6g of white vaseline, 0.8g of Span-80 and 0.1g of benzoic acid in the same container and heat and stir to melt. The temperature is 75-80°C; add 1.1g of lomefloxacin hydrochloride and 0.04g of disodium edetate into 72g of distilled water, heat to dissolve, add 4g of glycerin, 2g of triethanolamine, and 2g of Tween-80 and stir well, and control the temperature at 75-80°C; when the temperature of the two phases is the same, add the water phase to the oil phase, stir while adding, and finally add an appropriate amount of essence, stir well to 50±5°C, after the content is qualified, divide the package, and the product is ready.

Embodiment 2

[0022] Take 21.6g of stearic acid, 9.6g of glyceryl monostearate, 4.8g of liquid paraffin, 3.2g of white petrolatum, 1.6g of Span-80 and 0.2g of benzoic acid in the oil phase and put them together in the same container for heating, stirring and melting. The temperature is 75-80°C; add 2.2g of lomefloxacin hydrochloride and 0.08g of disodium edetate into 144g of distilled water, heat and dissolve, add 8g of glycerin, 4g of triethanolamine, and 4g of Tween-80 and stir well, and control the temperature at 75-80°C; when the temperature of the two phases is the same, add the water phase to the oil phase, stir while adding, and finally add an appropriate amount of essence, stir until the temperature is 50±5°C, after the content of the test is qualified, then pack it, that is have to.

Embodiment 3

[0024] Take 54g of stearic acid, 24g of glyceryl monostearate, 12g of liquid paraffin, 8g of white petrolatum, 4g of Span-80 and 0.5g of benzoic acid in the oil phase and put them together in the same container for heating, stirring and melting, and control the temperature at 75-80 ℃; Add 5.53g of lomefloxacin hydrochloride and 0.2g of disodium edetate into 360g of distilled water, heat to dissolve, add 20g of glycerin, 10g of triethanolamine, and 10g of Tween-80 and stir well, and control the temperature at 75-80°C; When the temperature of the two phases is the same, add the water phase to the oil phase, stir while adding, and finally add an appropriate amount of essence, stir well until the temperature is 50±5°C, after the content is qualified, divide the package to obtain the product.

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Abstract

The invention belongs to the field of medicinal preparations, and particularly relates to lomefloxacin hydrochloride emulsifiable paste and a preparation method thereof. The lomefloxacin hydrochloride emulsifiable paste comprises the following components in part by weight: 0.5 to 5 parts of lomefloxacin hydrochloride, 6.8 to 105 parts of oil phase component, 52.01 to 165 parts of water phase component and 0.01 to 5 parts of preservative. The prepared paste can act on infected parts directly, so that local medicinal concentration is high, and adverse reaction caused by oral administration or venous administration is avoided. The lomefloxacin hydrochloride emulsifiable paste is definite in curative effect, and a process is stable and is suitable for large-scale industrial production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a lomefloxacin hydrochloride cream and a preparation method thereof. Background technique [0002] Lomefloxacin hydrochloride is a new type of fluoronoquinone antibacterial drug. On the one hand, it maintains the 6-position fluorine atom on the quinoline ring of the chemical structure of norfloxacin, ciprofloxacin, ofloxacin, etc., so that it improves the The ability to bind to bacterial DNA gyrase and increase the permeability to the bacterial cell wall, the antibacterial activity is significantly enhanced, and the antibacterial spectrum is broad. In addition, the fluorine atom was introduced into the 8-position of lomefloxacin hydrochloride, and the methyl group was introduced into the 3-position of the 7-position piperazinyl group, which not only enhanced the absorption of the digestive tract and the urinary excretion of the prototype drug, but also prolonged the hal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/496A61K47/44A61P17/00A61P31/04
Inventor 刘博李俊霞程永科
Owner TIANJIN PHARMA GROUP XINZHENG
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