Novel Block Copolymer, Micelle Preparation, And Anticancer Agent Containing The Same As Active Ingredient

a technology of micelle and anticancer agent, which is applied in the direction of biocide, drug composition, animal husbandry, etc., can solve the problems of reduced stability of pharmaceutical preparation and difficult administration, and achieve the effects of less toxicity, increased water solubility of drug, and more potent drug activity
US20080113028A1Inactive Publication Date: 2008-05-15NIPPON KAYAKU CO LTD
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
NIPPON KAYAKU CO LTD
Publication Date
2008-05-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

A medicinal preparation is desired which has no harmful side effects such as hypersensitive reaction, heightens the water solubility of a sparingly water-soluble anticancer agent, maintains a high drug concentration in the blood, accumulates a drug in a tumor tissue at a high concentration, heightens the pharmacological effect of the sparingly water-soluble anticancer agent, and diminishes the side effects of the anticancer agent. Provided are: a novel block copolymer which can be a drug carrier having no harmful side effects such as hypersensitive reaction; a micelle preparation in which micelles are formed and which contains a sparingly water-soluble anticancer agent, especially paclitaxel, incorporated in the micelles in an amount necessary for a disease treatment without bonding it to the block copolymer and which can heighten the solubility of the drug in water; and an anticancer agent which comprises the micelle preparation as a medical ingredient, maintains a high concentration in the blood, has more potent drug activity, and is reduced in toxicity.
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Description

TECHNICAL FIELD

[0001] The present invention relates to a novel block copolymer, a micelle preparation using the same, and an anticancer agent containing the micelle preparation as an active ingredient.BACKGROUND ART

[0002] Many of drugs, particularly anticancer agents, are sparingly water-soluble hydrophobic compounds. When such drug is used to attain a desired therapeutic effect, the drug is usually solubilized and administered to a patient. Accordingly, solubilization of sparingly water-soluble drugs, particularly sparingly water-soluble anticancer agents, is important for oral or parenteral pharmaceutical preparations, particularly those for intravenous administration.

[0003] As one method of solubilizing a sparingly water-soluble anticancer agent, there is a method which comprises adding a surfactant, and it is known to use, for example, a polyoxyethylene castor oil derivative (Cremophor) in order to solubilize paclitaxel. As an another method, a method of using a micelle-forming blo...

Claims

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