The invention relates to a high-strength aluminum alloy slab and a manufacturing method thereof. The alloy mainly comprises the following components: less than 0.35% of Si, less than 0.45% of Fe, 1.25-1.95% of Cu, less than 0.30% of Mn, 2.25-2.85% of Mg, 0.19-0.27% of Cr, 5.2-6.0% of Zn, less than 0.2% of Ti, less than 0.04% of Zr and the balance of Al and unavoidable elements. The manufacturing method of the high-strength aluminum alloy slab is free of a rolling process and comprises the following flows: proportioning raw materials, smelting, casting a flat ingot, carrying out two-stage soaking, sawing the head and bottom of the flat ingot, carrying out fixed-length sawing and width-fixed sawing, sawing upper and lower surfaces of the flat ingot, sawing the flat ingot into the aluminum plate according to requirements, carrying out solid solution quenching, stretching and flattening and carrying out aging treatment. By the manufacturing method, the production process flows can be shortened, such problems of the slab manufactured by a hot rolling method as uneven microstructure and performance, poor flatness and uneven thickness are solved, the yield is increased, the cost of the product is decreased and the economic benefits are increased.