Implant surface biomimetic coating material for promoting sacralization and preparation method thereof

A technology for coating materials and implants, applied in the direction of coating, can solve the problems of synergistic doping of calcium phosphate coating materials, and achieve the effects of suitable biodegradability, inhibiting osteoclast activity, and promoting biological activity.

Inactive Publication Date: 2010-09-15
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The in vivo experiments and clinical application studies of the above trace elements have shown that trace elements play an important role in regulating bone metabolism, enhancing bone strength, and promoting tissue regeneration in osteoporosis. Calcium-coated materials synergistically doped and play a role in promoting bone fusion has not been reported yet

Method used

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  • Implant surface biomimetic coating material for promoting sacralization and preparation method thereof
  • Implant surface biomimetic coating material for promoting sacralization and preparation method thereof
  • Implant surface biomimetic coating material for promoting sacralization and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0038] 1) Dip multiple pieces of metal titanium sheets (length×width: 10mm×10mm) in 6mmol / L NaOH solution, and maintain them in a 60°C water bath for 24 hours, then take out the titanium sheets and wash them with deionized water and ethanol for several Repeat, dry at room temperature, and set aside.

[0039] 2) Formulated with Na + , 142mmol / L; K + , 5mmol / L; Ca 2+ , 2.5mmol / L; Mg 2+ , 1.5mmol / L; SO 4 2- , 1mmol / L; HPO 4 2- , 1mmol / L; Cl - , 163mmol / L and HCO 3 - , 1.0L of 4mmol / L simulated body fluid with a pH of 7.4 was equally divided into two 500ml clean strain bottles, marked as A and B respectively. Add Na to the above solution in bottle A under stirring condition 2 SiO 3 , Zn(NO 3 ) 2 and Sr(NO 3 ) 2 solution. Control the molar ratios of Sr:Ca, Si:Ca and Zn:Ca to be 3:100, 6:100 and 0.8:100 respectively, then add polyaspartic acid to the above solution to control the concentration of organic macromolecules to 20 μM, And adjust the pH value to 7.4; the ...

Embodiment 2

[0042] The preparation method is the same as in Example 1, except that the metal titanium sheet in step 1) is pretreated with 1.5 mmol / L hydrochloric acid to investigate the influence of different titanium sheet treatment methods on the coating. The acid treatment method is: immerse the metal titanium sheet in 1.5mmol / L HCl solution for 4 minutes, then wash it with deionized water and ethanol, and the rest of the treatment is the same as in Example 1. as attached Figure 4 As shown, the surface of metal titanium forms a deposited layer after chemical deposition of biomimetic solution.

Embodiment 3

[0044] The preparation method is the same as in Example 1, except that the molar ratios of Sr: Ca, Si: Ca and Zn: Ca in the control step 2) are respectively 10: 100, 8: 100 and 1.2: 100, and the solution is equally divided into 4 In a 250ml clean bacteria bottle, marked as A, B, C and D, immerse the titanium piece in the solution, place the A bottle in a water bath at 37, 60 and 90°C for 4 hours, then take it out, wash and dry it. as attached Figure 5 As shown, the uniformity and thickness of the deposition layer formed on the surface of metal titanium after biomimetic solution chemical deposition treatment increases with the increase of treatment temperature.

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Abstract

The invention discloses an implant surface biomimetic coating material for promoting the sacralization and a preparation method thereof. The coating material is a compound of calcium phosphate cooperatively doped with various trace elements and organic macromolecules. The preparation method comprises the following steps of: immersing an artificial implant pretreated by acid or alkali in simulated body fluid containing various trace element ions and organic macromolecules; carrying out chemical precipitation treatment between 35 DEG C and 150 DEG C to ensure that the surface of the implant is subjected to calcium phosphate salt core forming and growth; and forming a continuous coating of calcium phosphate salt cooperatively doped with various trace elements and the organic macromolecules. The surface of the coating has a nanoscale fine structure, and the effects of slowly degrading and releasing active ions of calcium, phosphorus and various trace elements and promoting the sacralization of implants for diseased intraosseous injuries, bone fracture internal fixation and tooth root internal fixation in the oral cavity. The coating material has the characteristics of simple preparation process, controllable coating thickness, trace element content, crystallinity and degradation rate, and the like.

Description

technical field [0001] The invention relates to a bioactive coating modification technology on the surface of a metal or alloy-based biomedical implant material, in particular to a biomimetic coating material on the surface of an implant for promoting bone fusion and a preparation method thereof, belonging to the technical field of biomedical materials. Background technique [0002] Osteoporotic fractures, tooth defects, and brain diseases are important causes of bone injury or bone loss in people of all ages. Due to biomechanical requirements, such bone and tooth lesions generally require metal or alloy implants for internal fixation Or to seal the wound and other purposes. A bioactive biocoating is a prerequisite for rapid fusion between the implant and the host bone at the implant site and satisfactory biomechanics. In orthopedics, orthopedics, plastic surgery, craniocerebral surgery, and stomatology, titanium metal (or alloy), aluminum oxide, magnesium alloy, etc. are w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/32
Inventor 苟中入高欣杨贤燕甘亦来
Owner ZHEJIANG UNIV
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