Preparation of nano-coating micropore surface implant having regeneration activity and antibacterial property

Abstract

The invention relates to the preparation of a nano-coating micropore surface implant having a regeneration activity and an antibacterial property. The preparation is characterized in that the implant is a dental implant taking pure titanium or titanium alloy as a matrix and an artificial joint medicinal hard tissue implant material; and the surface of a matrix material is subjected to micro-roughness treatment, improved biomimetic liquid treatment and nano silver grain coating technology treatment to form a nano biomimetic coating structure having the regeneration activity and the antibacterial property, wherein the nano silver grain is a metallic silver elementary substance which is attached to the surface of the implant and has the antibacterial property and a tissue repairing function, and has the grain diameter of 6 to 50nm; and a nano coating crystal grain formed on the surface of the implant through treatment and induction is a bone-like hydroxyapatite material rich in calcium and phosphor. The micro-nano biomimetic coating implant has a bone-promoting regeneration activity and a high affinity; compared with an un-coating material, the coating implant is improved in the bonding force with bones by several times so as to effectively avoid the phenomena of loosening and shedding and to be a novel medicinal implant material having both the antibacterial property and the regeneration activity.

Description

Technical field [0001] The invention relates to a technology for preparing medical materials for artificial implants (such as dental implants and artificial bone and joint implants) with nano bionic coating microporous surface with regenerative biological activity and antibacterial properties. Background technique [0002] Biomedical Materials and Biomedical Instruments are a type of high-tech new materials developed in the past 20 years. They are used to replace or repair human tissues and organs and enhance their physiological functions. Artificial materials and biological equipment, as well as biomedical materials and products have been commonly used in health, treatment and prevention fields. [0003] For a long time, various implants made of metals (such as cobalt, stainless steel, pure titanium, etc.), ceramics or polymers have been used clinically to replace materials. However, these materials are bioactive, biocompatibility, and biological guidance. It has its own shortcom...

AI Technical Summary

Problems solved by technology

Although the functional role of hydroxyapatite coating (HA-Coating) has been affirmed in a large number of animal experiments and clinical applications, many problems have gradually been exposed in the long-term application of this material. Recently, more and more The report pointed out that: with the prolonged load-bearing time in the body, the HA coating on the surface of this titanium alloy will cause separation and fragmentation, and tiny particles will fall off from the metal, resulting in cell-mediated osteolysis and joint loosening.

The research results show that the coating formed by the plasma spraying method is difficult to be uniform, and the temperature requirement in the preparation process is too high, and a thin layer of bioactive HA is prone to phase transition embrittlement. During the cooling process, the coating and the metal material There will also be a high residual stress between the implants, which will produce a certain solubility in body fluids after implantation, which will affect the stability and life of the coating.

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