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Preparation method of biomimetic coating containing epoxy phosphorylcholine polymer and dopamine cross-linked adhesion

A technology of epoxy phosphoryl choline and phosphoryl choline, applied in the direction of coating and the like, can solve the problems of harsh conditions in the synthesis process, difficult to store, limited application scope and the like

Inactive Publication Date: 2020-10-27
XIAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the crosslinkable group of the polymer is easy to hydrolyze and crosslink during the synthesis process, which makes the conditions of the synthesis process too harsh and difficult to preserve, which limits its application range

Method used

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  • Preparation method of biomimetic coating containing epoxy phosphorylcholine polymer and dopamine cross-linked adhesion
  • Preparation method of biomimetic coating containing epoxy phosphorylcholine polymer and dopamine cross-linked adhesion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Weigh 16mmol 2-methacryloyloxyethyl phosphorylcholine and 4mmol glycidyl methacrylate, use 0.1mmol azobisisobutyronitrile as initiator, methanol and tetrahydrofuran as solvent, under nitrogen protection, 70 ℃ polymerization reaction for 24 hours, dialyzed after the reaction, and then freeze-dried at -50 ℃ to obtain the epoxy-containing phosphorylcholine polymer.

[0028] Using a 400MHz NMR instrument to D 2 O is the hydrogen NMR of the solvent test polymer. There is no peak at 5-7ppm, indicating that there is no residual monomer in the resulting copolymer, and the polymer has been successfully synthesized, with 3.28ppm being -N + (CH 3 ) 3 Characteristic peaks, 0.9-2.2ppm are the peaks of methylene and side chain methyl groups on the main chain to calculate the polymer composition, and it can be known that the polymer composition is basically consistent with the feed ratio.

[0029] The epoxy-containing phosphorylcholine polymer prepared in this example was prepared...

Embodiment 2

[0033] Weigh 14mmol 2-methacryloyloxyethyl phosphorylcholine and 6mmol glycidyl methacrylate, use 0.1mmol azobisisobutyronitrile as initiator, methanol and tetrahydrofuran as solvent, under nitrogen protection, 70 ℃ polymerization reaction for 24 hours, dialyzed after the reaction, and then freeze-dried at -50 ℃ to obtain the epoxy-containing phosphorylcholine polymer.

[0034] The epoxy-containing phosphorylcholine polymer prepared in this example was prepared into 2 mL, 2 mg / mL methanol solution, and then 1 g of dopamine was added and mixed evenly. Then the above-mentioned mixed solution containing epoxy-containing phosphorylcholine polymer and dopamine is drop-coated on the chitosan surface. Among them, the mixed solution of phosphorylcholine polymer containing epoxy and dopamine is dripped and dried, and then placed in a pH=8.5 Tris-HCl aqueous solution at 45°C for 12 hours, so that the amino group in dopamine and the amino group on the surface of chitosan film are combine...

Embodiment 3

[0036] Weigh 19mmol 2-methacryloyloxyethylphosphorylcholine and 1mmol glycidyl methacrylate, use 0.1mmol azobisisobutyronitrile as the initiator, methanol and tetrahydrofuran as the solvent, under nitrogen protection, 70 ℃ polymerization reaction for 24 hours, dialyzed after the reaction, and then freeze-dried at -50 ℃ to obtain the epoxy-containing phosphorylcholine polymer.

[0037] The epoxy-containing phosphorylcholine polymer prepared in this example was prepared into 2 mL, 5 mg / mL methanol solution, and then 0.8 g of dopamine was added and mixed evenly. Then the above-mentioned mixed solution containing epoxy-containing phosphorylcholine polymer and dopamine is drop-coated on the chitosan surface. Among them, the mixed solution of phosphorylcholine polymer and dopamine containing epoxy is dripped and dried, and then placed in pH=8.5 Tris-HCl aqueous solution at 95 ° C for 2 hours, so that the amino group in dopamine and the amino group on the surface of chitosan film are...

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Abstract

The invention discloses a preparation method of a crosslinking adhesion bionic coating composed of an epoxy-containing phosphorylcholine polymer and dopamine. An epoxy-containing glycidyl methacrylate monomer and a methacryloyloxyethyl phosphorylcholine monomer containing a phosphorylcholine hydrophilic group are subjected to simple solution free radical polymerization to synthesize the epoxy-containing phosphorylcholine polymer, which is then dissolved in a polar solvent along with dopamine to form a coating for coating the surface of a material requiring modification. The coating is then air-dried and is subjected to heating treatment in a Tris-HCl water solution with pH being 8.5, so that amino groups in the dopamine and on the surface of the a chitosan film are reacted with epoxy groups in the phosphorylcholine polymer and meanwhile crosslinking adhesion of the dopamine is carried out. By means of anchoring through reaction of the epoxy groups in the phosphorylcholine polymer and the amino groups on the surface of the chitosan film and adhesion of the dopamine, the phosphorylcholine group is fixed on the surface of the surface of the chitosan film, thereby producing the crosslinking adhesion bionic coating that can imitate a cellular outer membrane.

Description

technical field [0001] The invention relates to the technical fields of material surface science and biomedical polymer materials, in particular to a preparation method of a bionic coating containing epoxy phosphorylcholine polymer and dopamine cross-linked and adhered. Background technique [0002] Chitosan has the advantages of degradability, antibacterial, non-toxic, non-irritating, and pH responsiveness (Carbohydrate Polymers 2010, 79: 724-730), and has been widely used in biomedicine and other fields. More and more studies have shown that chitosan and its derivatives can be used for blood purification. The amino group on the chitosan molecule helps to adsorb various toxins in the blood, and can be used as a hemoperfusion material (Chemical Journal of Chinese Universities 2002, 23: 75-77; Journal of Microencapsulation 1993, 10: 475-486). Chitosan membrane has high dialysis rate, selectivity and strength, and can be used as a hemodialysis material (Journal of Applied Pol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/04C08L5/08C09D143/02C09D7/63C08F230/02C08F220/32
CPCC08F230/02C08J2305/08C08J2443/02C08K5/17C08L2312/00C09D143/02C09D7/63C08J7/0427C08F220/325
Inventor 宫铭
Owner XIAN UNIV OF SCI & TECH
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