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Method of surface biocompatibility of modified material and biomimetic coating prepared from modified material

A technology of biocompatibility and modified materials, applied in a method and the field of biomimetic coatings prepared therefrom, can solve the problems of difficult preservation, limited application scope, harsh synthesis process conditions, etc., and achieves convenient operation and wide application. Prospect, effect of simple preparation method

Inactive Publication Date: 2018-11-13
XIAN UNVERSITY OF ARTS & SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology provides an easy way to create a thin film on cells without damaging them or causing damage during their use. Its technical effect lies within its ability to provide a more reliable and durable solution than current methods such as plasma treatment or chemical treatments used to make coatings.

Problems solved by technology

This patents discusses how different types of modifications made from natural compounds like carboxylic accharide monosachlorophyll AMPA, citrullose sulfurochrome estradation products, triphenols, etc., may result in decreased activity at certain points within the material's interior compared to unmodified ones. These modifications were found to reduce the risk of harmful interactions caused by foreign matters present inside the material itself. Additionally, modifying the inner wall of the porous shell surrounding the material helps prevent bioregalocyte aggregations and clump together without being absorbed onto healthy organs called cells. By combining specific chemistry principles with ion exchange resists, the modified layers could effectively enhance blood compatibilization while maintaining excellent blood compatibility characteristics.

Method used

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  • Method of surface biocompatibility of modified material and biomimetic coating prepared from modified material
  • Method of surface biocompatibility of modified material and biomimetic coating prepared from modified material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032]Weigh 16mmol 2-methacryloyloxyethylphosphorylcholine and 4mmol pentafluorophenyl methacrylate, use 0.1mmol azobisisobutyronitrile as the initiator, and use methanol and tetrahydrofuran as the solvent (volume ratio 4: 1), under the protection of nitrogen, carry out the polymerization reaction at 70°C for 24h, concentrate the reaction solution after the reaction, and perform dialysis with a dialysis bag with a molecular weight cut-off of 6000-8000D; then freeze-dry at -50°C to obtain pentafluorobenzene-containing based phosphorylcholine polymers.

[0033] Using a 400MHz NMR instrument to D 2 O is the hydrogen NMR of the solvent test polymer. No peak was seen at 5-7ppm, indicating that there was no residual monomer in the resulting copolymer, and the polymer was successfully synthesized with -N at 3.28ppm + (CH 3 ) 3 Characteristic peaks, 0.9-2.2ppm are the peaks of methylene and side chain methyl groups on the main chain to calculate the polymer composition, and it can...

Embodiment 2

[0038] Weigh 14mmol 2-methacryloyloxyethyl phosphorylcholine and 6mmol pentafluorophenyl methacrylate, use 0.1mmol azobisisobutyronitrile as the initiator, and use methanol and tetrahydrofuran as the solvent (volume ratio 4: 1), under the protection of nitrogen, carry out the polymerization reaction at 70°C for 24h, concentrate the reaction solution after the reaction, and perform dialysis with a dialysis bag with a molecular weight cut-off of 6000-8000D; then freeze-dry at -50°C to obtain pentafluorobenzene-containing based phosphorylcholine polymers.

[0039] The phosphorylcholine polymer containing pentafluorophenyl prepared in this example was prepared into 2 mL, 2 mg / mL methanol solution, and then 1.2 g of dopamine was added and mixed evenly. Then the above-mentioned mixed solution of phosphorylcholine polymer containing pentafluorophenyl and dopamine is drop-coated on the chitosan surface. Among them, the mixed solution of phosphorylcholine polymer containing pentafluor...

Embodiment 3

[0041] Weigh 12mmol 2-methacryloyloxyethylphosphorylcholine and 8mmol pentafluorophenyl methacrylate, use 0.1mmol azobisisobutyronitrile as the initiator, and use ethanol and tetrahydrofuran as the solvent (volume ratio 4: 1), under the protection of nitrogen, polymerize at 70°C for 24h, concentrate the reaction solution after the reaction, and perform dialysis with a dialysis bag with a molecular weight cut-off of 6000-8000D; then freeze-dry at -50°C to obtain a pentafluorophenyl-containing of phosphorylcholine polymers.

[0042] The phosphorylcholine polymer containing pentafluorophenyl prepared in this example was prepared into 2 mL, 5 mg / mL methanol solution, and then 0.8 g of dopamine was added and mixed evenly. Then the above-mentioned mixed solution of phosphorylcholine polymer containing pentafluorophenyl and dopamine is drop-coated on the chitosan surface. Among them, the mixed solution of phosphorylcholine polymer containing pentafluorophenyl and dopamine is drip-co...

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Abstract

The invention belongs to the technical field of material surface science and polymeric biomedical materials, and particularly relates to a method of surface biocompatibility of a modified material anda biomimetic coating prepared from the modified material. The method comprises the following steps: ensuring that pentafluorophenyl methacrylic acid pentafluorophenyl ester monomer containing pentafluorobenzene groups and methacryloyloxyethyl phosphorylcholine containing phosphorylcholine hydrophile grouphydrophile group are subjected to simple solution radical polymerization reaction, so as to form phosphorylcholine polymer containing pentafluorobenzene groups, ensuring that the phosphorylcholine polymer and dopamine into a polar solvent, coating the phosphorylcholine polymer onto the surface of a modified chitosan membrane to ensure that the pentafluorobenzene groups are reacted with amidogen on the surface of the chitosan membrane and in dopamine, and fixing phosphorylcholine groups onto the surface of the chitosan membrane through polymerization adhesive attraction of dopamine and pentafluorobenzene group nucleophilic substitution grafting, so as to form the adhesive biomimetic coating with an imitation cellulosa membrane structure.

Description

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Claims

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Application Information

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Owner XIAN UNVERSITY OF ARTS & SCI
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