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Method for preparing phosphorylcholine biomimetic coating by photocuring

A phosphorylcholine and light-curing technology, applied in coatings, devices for coating liquids on surfaces, etc., can solve problems such as the difficulty of increasing surface requirements, lengthy and complicated processing processes, etc., and achieve mild conditions, broad application prospects, The effect of simple preparation method

Inactive Publication Date: 2015-07-01
XIAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This undoubtedly increases the difficulty of the surface requirements for the synthesis and application of this type of phosphorylcholine polymer, and also makes the process of this technology lengthy and complicated.

Method used

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  • Method for preparing phosphorylcholine biomimetic coating by photocuring
  • Method for preparing phosphorylcholine biomimetic coating by photocuring

Examples

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Effect test

Embodiment 1

[0029] The present embodiment prepares phosphorylcholine biomimetic coating on polycarbonate (film shape) surface, and specific method comprises:

[0030] Step 1. Weigh 12mmol 2-methacryloyloxyethyl phosphorylcholine and 8mmol β-hydroxyethyl methacrylate, dissolve and mix with distilled water to obtain a mixed solution of monomers, and use 0.1mmol potassium persulfate Dissolved in distilled water to obtain the initiator solution, in N 2 Protection, under the condition of stirring at 70°C, add the mixed solution of monomers into the three-necked flask, preheat for 30 minutes, add the initiator solution and continue the reaction for 12 hours. bag dialysis; finally, freeze-dry the dialyzed sample at -50°C to obtain a hydroxyl-containing phosphorylcholine polymer;

[0031] Step 2, the hydroxyl-containing phosphorylcholine polymer and the sensitizer described in step 1 are dissolved in distilled water at a mass ratio of 19:1, and stirred evenly to obtain the hydroxyl-containing ph...

Embodiment 2

[0037] The present embodiment prepares phosphorylcholine biomimetic coating on the surface of cellulose (film shape), and specific method comprises:

[0038] Step 1. Weigh 3mmol of acryloyloxyethylphosphorylcholine and 7mmol of β-hydroxyethyl methacrylate, dissolve and mix them uniformly in distilled water to obtain a mixed solution of monomers, and dissolve 0.1mmol of potassium persulfate in distilled water to obtain agent solution, in N 2 Protection, under the condition of stirring at 70°C, add the mixed solution of monomers into the three-necked flask, preheat for 30 minutes, add the initiator solution to continue the reaction for 12 hours, after the reaction is completed, concentrate the reaction solution, and use a dialyzer with a molecular weight cut-off of 6000-8000D bag dialysis; finally, freeze-dry the dialyzed sample at -50°C to obtain a hydroxyl-containing phosphorylcholine polymer;

[0039] Step 2, the hydroxyl-containing phosphorylcholine polymer and the sensitiz...

Embodiment 3

[0044] Present embodiment prepares phosphorylcholine biomimetic coating on chitosan (film shape) surface, and specific method comprises:

[0045] Step 1. Weigh 9 mmol of acrylamide ethyl phosphorylcholine and 1 mmol of β-hydroxyethyl acrylamide, dissolve and mix them uniformly with distilled water to obtain a mixed solution of monomers, dissolve 0.1 mmol of potassium persulfate with distilled water to obtain an initiator solution, and N 2 Protection, under the condition of stirring at 70°C, add the mixed solution of monomers into the three-necked flask, preheat for 30 minutes, add the initiator solution to continue the reaction for 12 hours, after the reaction is completed, concentrate the reaction solution, and use a dialyzer with a molecular weight cut-off of 6000-8000D bag dialysis; finally, freeze-dry the dialyzed sample at -50°C to obtain a hydroxyl-containing phosphorylcholine polymer;

[0046] Step 2, the hydroxyl-containing phosphorylcholine polymer and the sensitizer...

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Abstract

The invention discloses a method for preparing phosphorylcholine biomimetic coating by photocuring. The method comprises the following steps: I, preparing a phosphorylcholine polymer containing hydroxyl; II, solving the phosphorylcholine polymer containing hydroxyl and a sensitizer together in a polar solvent and uniformly to obtain a coating solution; and III, coating the coating solution on the surface of a modified material, carrying out a curing reaction on the aired material under ultraviolet illumination, and washing to obtain the phosphorylcholine biomimetic coating on the surface of the to-be-modified material. According to the phosphorylcholine polymer containing hydroxyl synthesized by a vinyl monomer containing a phosphorylcholine group and a vinyl monomer containing hydroxyl by virtue of a polymerization method, the phosphorylcholine polymer containing hydroxyl and the sensitizer are mixed and coated on the surface of the to-be-modified material and the phosphorylcholine polymer can be well cured on the surface of the to-be-modified material under ultraviolet illumination, so that a novel path for obtaining a stable phosphorylcholine biomimetic coating is provided.

Description

technical field [0001] The invention belongs to the technical fields of material surface science and biomedical polymer materials, and in particular relates to a method for preparing a phosphorylcholine biomimetic coating by photocuring. Background technique [0002] When the material is used in a living body, it is easy to non-specifically adsorb proteins, activate complement molecules and the immune system, thereby causing blood coagulation, immune and inflammatory reactions, resulting in a significant decrease in its performance or even failure. This is due to the poor biocompatibility of materials, therefore, biocompatibility research has become the primary issue in the field of biomaterial research. The surface of a material is the medium through which the material contacts the organism. Surface charge, hydrophilicity / hydrophobicity, chemical composition, and morphology are important factors that affect the interface interaction between the material and the organism, an...

Claims

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Application Information

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IPC IPC(8): C08J7/04C09D133/14C09D7/12B05D7/24C08F220/36C08F220/28C08F220/58
Inventor 宫铭郭培培
Owner XIAN UNIV OF SCI & TECH
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