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Antibacterial bionic coating as well as preparation method and application thereof

A technology of coatings and coating materials, applied in coatings, pharmaceutical formulations, catheters, etc., can solve problems such as the decline in the content of antibacterial active components, immune reactions and inflammation, and affect the effective period of antibacterial, and achieve short response time and good antibacterial properties The effect of the property and the simple preparation method

Active Publication Date: 2021-12-28
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The representative technology of the former is surface coupling or coating antibacterial materials, such as organic small molecule antibacterial agents and synthetic polymer antibacterial agents containing quaternary ammonium, haloamine, guanidine and quaternary phosphine, chitosan and its derivatives, silver-containing compounds Inorganic antibacterial agents, etc., can effectively kill surrounding bacteria and microorganisms, but on the one hand, the bacteria and microorganisms killed on the surface of implanted materials or devices may still cause immune reactions and inflammation; on the other hand, the content of antibacterial active components continues to decline over time , affect the antibacterial effective period, and may have toxic effects on normal cells
The representative technology of the latter is the introduction of polyethylene glycol or polyzwitterions (such as phosphorylcholine, sulfobetaine, etc.) compounds with anti-protein and bacterial adhesion functions on the surface, which can effectively reduce bacterial adhesion and inhibit biofilm formation. Formation, and has good hemocompatibility and cell compatibility, but there is still the risk of bacterial introduction and implantation failure in clinical use

Method used

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  • Antibacterial bionic coating as well as preparation method and application thereof
  • Antibacterial bionic coating as well as preparation method and application thereof
  • Antibacterial bionic coating as well as preparation method and application thereof

Examples

Experimental program
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preparation example Construction

[0044] Described zwitterionic polymer PVAm-PC is specifically prepared by the following method:

[0045] At 55°C, the methanol solution of aldylated glycerophosphorylcholine (PCGA) was added dropwise to the methanol solution of polyvinylamine (PVAm), wherein the molar ratio of PCGA to PVAm was 1:0.25, and the reaction was stirred for 24 hours to obtain reaction mixture. Sodium cyanoborohydride (NaBH 3 CN) methanol solution was added dropwise to the reaction mixture cooled to 0°C, where NaBH 3 The molar ratio of CN to PCGA was 1:1, heated to room temperature and stirred for 24 h, dialyzed with deionized water (molecular weight cut-off 500) for 3 days, and freeze-dried to obtain phosphorylcholined polyvinylamine (PVAm-PC). where y / (x+y)=0.5.

[0046] The zwitterionic polymer CS-PC described in the embodiment has following molecular structure:

[0047]

[0048] Wherein, x=200, y=800, n=2000.

[0049] The CS-PC was prepared by the following method: at 60°C, a deionized aqueo...

Embodiment 1

[0050] Example 1 Preparation of polyphenol / zinc-zwitterionic polymer coating on the surface of medical catheter

[0051] (1) Surface activation of medical catheters

[0052] Ultrasonic cleaning of medical catheters with a diameter of 1 cm and a height of 3 cm in acetone, ethanol, and deionized water for 10 minutes, and preparing 3 mol / L sodium hydroxide solution, soaking the cleaned medical catheters in it, soaking at 60 ° C for 2 hours, and then ultrasonic cleaning 10min.

[0053] (2) Preparation of polyphenol / zinc coating

[0054] 40mg of epigallocatechin gallate (EGCG), 20mg of zinc acetate and 20mg of ammonium persulfate were added to 40mL of pH in the PBS buffer solution of 8.0, stirred evenly to obtain a mixed solution; step (1) The treated medical catheter and the mixed solution were added to a polytetrafluoroethylene-lined hydrothermal reaction kettle, and reacted at 80°C for 5 hours. After the reaction was completed, it was washed with deionized water and dried in v...

Embodiment 2

[0057] The preparation of embodiment 2 polyurethane sponge dressing surface polyphenol / zinc-zwitterionic polymer coating

[0058] (1) Clean the polyurethane sponge and activate the surface

[0059] Ultrasonic cleaning of 1×1×2 cm polyurethane sponges in deionized water for 15 minutes, preparation of 2 mol / L sodium hydroxide solution, soaking the cleaned polyurethane sponges at 60°C for 1 hour, and then ultrasonic cleaning for 20 minutes.

[0060] (2) Preparation of polyphenol / zinc coating

[0061] 40mg of epigallocatechin gallate (EGCG), 20mg of zinc acetate and 20mg of ammonium persulfate were added to 40mL of pH in the PBS buffer solution of 8.0, stirred evenly to obtain a mixed solution; step (1) The treated polyurethane sponge and the mixed solution were added together into a polytetrafluoroethylene-lined hydrothermal reaction kettle, and reacted at 70°C for 2 hours. After the reaction, it was washed with deionized water and dried in vacuum to obtain polyphenol / zinc coati...

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Abstract

The invention belongs to the technical field of medical materials, and discloses an antibacterial bionic coating as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, activating the surface of a base material, then putting the activated base material into a neutral or slightly alkaline buffer solution, adding a polyphenol compound, zinc salt and the like to carry out a one-pot hydrothermal reaction, cleaning a product obtained by the reaction, then preparing a polyphenol / zinc-zwitter-ion coating through a hydrothermal method, and obtaining the antifouling and antibacterial bionic coating material with hydrophilicity. The preparation method is simple, reaction conditions are mild, and the prepared polyphenol / zinc-zwitter-ion coating material is good in safety, has the good antibacterial property, biocompatibility and the hydrophilic antifouling property and can be widely applied to the field of medical materials.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to an antibacterial bionic coating and a preparation method and application thereof. Background technique [0002] The adhesion of microorganisms such as bacteria on the surface of implanted biomaterials or medical devices and the subsequent formation of biofilms are one of the main reasons for implant infection and medical device failure, which seriously threaten human health and life safety. At present, the application of antimicrobial agent coating (active antibacterial) and the formation of anti-bioadhesive surface (inert antibacterial) are two strategies to solve the complications or failure of implanted devices caused by microbial infection. The representative technology of the former is surface coupling or coating antibacterial materials, such as organic small molecule antibacterial agents and synthetic polymer antibacterial agents containing quaternary ...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L29/10A61L29/14A61L29/16A61L15/24A61L15/28A61L15/18A61L15/20A61L15/42A61L15/46C08F8/40C08F126/02C08B37/08
CPCA61L29/085A61L29/08A61L29/106A61L29/14A61L29/16A61L15/24A61L15/28A61L15/18A61L15/20A61L15/425A61L15/46C08F8/40C08B37/003A61L2300/404A61L2300/606A61L2400/18A61L2420/02A61L2420/04A61L2420/06C08L39/02C08L5/08C08F126/02
Inventor 曾戎谢明阳屠美
Owner JINAN UNIVERSITY
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