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Porous, laminated, tri-dimensional multiple-grade structure tissue stent material and its preparation method

A technology of tissue scaffolding and three-dimensional space, which can be applied in the fields of coating, medical science, prosthesis, etc., and can solve problems such as unsatisfactory treatment effects

Inactive Publication Date: 2006-09-27
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Human tissue (such as nerves, blood vessels, esophagus, trachea, anus, etc.) injuries and defects are common in clinical practice, and so far, the therapeutic effect is still unsatisfactory

Method used

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  • Porous, laminated, tri-dimensional multiple-grade structure tissue stent material and its preparation method
  • Porous, laminated, tri-dimensional multiple-grade structure tissue stent material and its preparation method
  • Porous, laminated, tri-dimensional multiple-grade structure tissue stent material and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1. Preparation of Scaffold Materials

[0036] 1. Preparation of core material: Dissolve 3 grams of polylactic acid with a weight average molecular weight of 30,000 in 10 milliliters of 1,4-dioxane, inject it into the mold, dry it at room temperature for 24 hours, remove the mold, and transfer it to a vacuum oven ( 20°C) to dry to constant weight, immerse in 1:1 ethanol-water to remove grease and impurities, and fully rinse with water;

[0037] ②Amination reaction: Immerse the above core material in 0.07 g / ml hexamethylenediamine-isopropanol, react at 37°C for 2 hours, rinse with water to remove unreacted hexamethylenediamine, and dry in a vacuum oven at 20°C until constant weight;

[0038] ③ Acidification reaction: Acidify the aminolytic PDLLA core material in 0.02 mol / L hydrochloric acid solution for 1 hour at room temperature, and rinse with a large amount of three-distilled water to remove the adsorbed hydrochloric acid;

[0039] ④Layer-by-layer electrostatic self-...

Embodiment 2

[0045] The same method and steps as in Example 1, but the core material adopts polyglycolic acid (molecular weight 120,000), and the self-assembled material adopts chondroitin sulfate and chitosan-collagen mixture for material preparation, and the number of assembled layers is 20 layers, and -70 ℃ freezer.

[0046] The cross-section of the conduit observed by the atomic force microscope has an obvious nano-scale layered structure, each layer has a uniform pore distribution, the pores between the layers are connected, and the pore size changes in grades. After being implanted in the body, the material degrades over time. According to the in vitro experiment, the material swelled in 15 days, the shape was complete in 2 months, and the pH value of the solution changed slightly.

[0047] The scanning electron microscope observed that the pore diameter of the inner layer was about 3 nanometers, and the outer layer was about 15 microns; the atomic force microscope observed that the...

Embodiment 3

[0049] The same method and steps as in Example 1, but the core material is polycaprolactone, and the self-assembled material is prepared from a mixture of chondroitin sulfate and chitosan-collagen. The number of assembled layers is 200 layers, and it is frozen in a -70°C refrigerator.

[0050] The cross-section of the conduit observed by the atomic force microscope has an obvious nano-scale layered structure, each layer has a uniform pore distribution, the pores between the layers are connected, and the pore size changes in grades. After being implanted in the body, the material degrades over time. According to the in vitro experiment, the material swelled in 15 days, the shape was complete in 2 months, and the pH value of the solution changed slightly.

[0051] The scanning electron microscope observed that the pore diameter of the inner layer was about 3 nanometers, and the outer layer was about 3500 nanometers; the atomic force microscope observed that the cross-section of ...

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Abstract

The present invention relates to porous laminated 3D tissue rack material and its preparation process. Polylactic aicd, polyglycolic acid, glycolic acid copolymer, polycaprolactone or other bioabsorbable material and chitosan, chondroitin sulfate, collegen, heparin sulfate, sodium alginate, hyaluronic acid, etc are used as the base material. The preparation process includes nanometer self-assembling to assemble chitosan, chondroitin sulfate or other positively or negatively charged medical polymer material to the surface of specific cylindrical core material, vacuum drying and freeze drying to form the highly bionic human body tubular tissue rack material with adjustable structure, size and shape.

Description

technical field [0001] The invention relates to a porous, layered, three-dimensional space multi-level structure tissue support material prepared based on nanometer self-assembly technology. In particular, it involves the selection of biomedical materials with good biocompatibility, biodegradability and bioinducibility, which have been widely used at home and abroad, and the preparation of tissue scaffolds with porous, layered, and three-dimensional multi-level structures that mimic human tubular tissues and preparation method. Background technique [0002] Tissue engineering is an emerging discipline that combines cell biology and materials science to construct tissues or organs in vitro or in vivo. When seed cells with specific functions are mixed with biodegradable polymers and cultured in vitro for a period of time or implanted in vivo, with the continuous proliferation of seed cells, the secretion of extracellular matrix and the gradual degradation of biomaterials Deg...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/34
CPCA61L27/58A61L27/56A61L27/48
Inventor 闫玉华徐海星李世普万涛袁琳贾莉李建华陈蕾
Owner WUHAN UNIV OF TECH
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