The invention discloses a preparation method of a fertilizer for preventing and controlling rice blast, and belongs to the field of fertilizers. According to the preparation method provided by the invention, brassinolide is compounded with diethyl aminoethyl hexanoate, and the main effects are as follows that on one hand, the carbon and nitrogen metabolism of plants are promoted, so that the vigorand the development of rice are improved; on the other hand, the crop yield is improved, and the crop quality is improved. According to the preparation method, a penetration enhancer is penetrated into the roots of the rice, the enzyme activation and the photosynthesis are promoted through the brassinolide and the diethyl aminoethyl hexanoate; then the activity of separately cultivated strains isgreatly increased under the action of the enzyme activation, so that the capability of resisting the invasion of magnaporthe grisea is promoted; and on the other hand, the active substances of the stems and leaves of kiwifruits are added, the propagation and the growth of the magnaporthe grisea in rice are inhibited, and the rice blast is controlled. The preparation method solves the problem thatsterilization agents are adopted to prevent and control the rice blast in the prior art, a large amount of manpower and material resources are wasted, and unnecessary pollution is caused to the environment, and unnecessary pesticide residue is generated in the rice.