Preparation and application of efficient two-photon nano diagnosis and treatment agent

A two-photon fluorescence and high-efficiency technology, applied in the field of nano-biomedical imaging, can solve the problem of single optical properties of inorganic materials, and achieve the effect of enhancing electronic activity

Active Publication Date: 2017-07-21
SHANGHAI UNIV OF MEDICINE & HEALTH SCI
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  • Abstract
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Problems solved by technology

However, the optical properties of inorganic materials are usually relatively simple, which is quite limited for practical research.

Method used

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  • Preparation and application of efficient two-photon nano diagnosis and treatment agent
  • Preparation and application of efficient two-photon nano diagnosis and treatment agent
  • Preparation and application of efficient two-photon nano diagnosis and treatment agent

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Embodiment Construction

[0038] Below in conjunction with embodiment, the present invention will be further described:

[0039] figure 1 a is the specific preparation flow chart of ZMT coated with PLL

[0040] 1. Preparation of ZnTPyP-MOF hydrophobic nanoparticles:

[0041] 1. ZnTPyP-H 4 4+ Preparation: ZnTPyP was dissolved in 0.2mol / L hydrochloric acid solution to obtain 0.01mol / L ZnTPyP solution.

[0042] 2. Preparation of CTAB micellar solution: CTAB was dissolved in 10 mmol / L NaOH solution to obtain 2 mmol / L CTAB solution.

[0043] 3. Take 0.5mL of ZnTPyP solution and quickly add 9.5mL of CTAB solution, stir slowly for 5 minutes, add alcohol, 10000 rpm, and quickly centrifuge to collect the product.

[0044] figure 1 b-c are SEM spectra of ZnTPyP-MOF nanocrystals prepared in this example, in the figure: the ZnTPyP-MOF is a hexagonal nanodisk.

[0045] figure 1 d is the EDS diagram of element distribution of ZnTPyP-MOF nanocrystals prepared in this example. In the figure: carbon and zinc el...

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Abstract

The invention belongs to the field of nanobiomedicine diagnosis and treatment, and mainly relates to preparation of an organic/inorganic composite nano material system with high biocompatibility and application of the organic/inorganic composite nano material system in biological two-photon imaging and dual photosensitization dynamic therapy. According to the preparation disclosed by the invention, by adoption of an supramolecular self-assembling driver of a metal porphin complex, a functional metal-organic framework material ZnTPyP-MOF, so that the physical and chemical characteristics of an original assembling molecule ZnTPyP are retained, and the original assembling molecule ZnTPyP is endowed with new optical and structural characteristics. The MOF is used as a kernel for growing titanium oxide serving as a shell coated with a layer of polylysine, thus obtaining a high-performance two-photon diagnosis and treatment nano biological probe. The nano probe is high in biological safety and dispersity; and the ZnTPyP-MOF is high in two-photon absorption and fluorescence emission performance and realizes the photosensitization dynamic therapy under activation of two photons. The organic/inorganic composite nano material system can be widely applied to in-situ fluorescence diagnosis and treatment of various diseases, particularly the cancer, and has very important in clinical medicine.

Description

technical field [0001] The invention belongs to the technical field of nanometer biomedical imaging, and mainly relates to the preparation of a high-efficiency two-photon fluorescent probe with good biocompatibility and its application in two-photon sensitization dynamic therapy. Background technique [0002] Porphines and metalloporphins are the structural skeletons of various porphyrin-like tetrapyrrole compounds such as chlorophyll and heme in nature, and are the substances on which life exists. Porphine molecules usually have good biocompatibility and play an important role in the process of photoelectric conversion. As a family member of macrocyclic organic molecules, porphine molecules can be used as basic molecules to realize supramolecular self-assembly through π-π stacking, hydrogen bonding and van der Waals forces, and to obtain nanocrystals with various morphologies. . From basic molecules to assembled nanocrystals, the optoelectronic properties of materials hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64C09K11/06C08G83/00
CPCC08G83/008C09K11/06C09K2211/188G01N21/6402G01N21/6486
Inventor 刘艳颜孟宪福李伟步文博
Owner SHANGHAI UNIV OF MEDICINE & HEALTH SCI
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