Improved methods and devices are provided for detecting and / or predicting the onset of an undesirable physiological event or neural state, such as an
epileptic seizure, to facilitate rapid intervention with a treatment therapy such as
neurostimulation or
drug therapy. The methods and devices involve monitoring the patient's body temperature, preferably by an implanted temperature sensor, to detect a change in a body temperature parameter over a first time period. The temperature parameter change may comprise an increase or decrease in the patient's body temperature over a first time period,
time rate of change of body temperature over a first time period, a
moving average temperature over a first time period, an increase or decrease in body temperature exceeding a target temperature over a first time period, an elevated or reduced body temperature over first time period, or a temperature
stability parameter over a first time period. The sampling period at which body temperature measurements are made may be changed manually or depending upon a sensed body parameter, including temperature. When a parameter change is detected that exceeds a threshold,
neurostimulation therapy is delivered to a neural structure of the patient.