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Panax notoginseng loaded hemostatic tissue repair membrane and preparation method thereof

A tissue repair and tissue membrane technology, applied in the field of biomedicine, can solve the problems of high time difficulty and high difficulty in surgery, and achieve the effect of easy operation and good hemostatic function.

Inactive Publication Date: 2014-12-24
MEDPRIN REGENERATIVE MEDICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the existing surgical implants are made of tissue repair materials prepared by electrospinning of polymer materials. Although these tissue repair materials have the characteristics of good permeability, high porosity, softness and easy fit, they can promote tissue or However, the vast majority of surgical implants, such as dura mater patch, hernia repair patch, dermal graft, etc., often need to clean the wound and stop bleeding when implanted in the human body, so as to ensure that the implant can be compatible with the The wounds are tightly bonded together, and for some bleeding-prone parts, the time for hemostasis and wound cleaning is very difficult, so the difficulty of surgery is also high

Method used

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  • Panax notoginseng loaded hemostatic tissue repair membrane and preparation method thereof
  • Panax notoginseng loaded hemostatic tissue repair membrane and preparation method thereof
  • Panax notoginseng loaded hemostatic tissue repair membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] S1. Preparation of electrospinning solution; select copolymer PLGA (lactic acid: glycolic acid = 50:50) with a molecular weight of 180,000, and prepare an electrospinning solution with a concentration of 15% (mass / volume ratio). The solvent used was trifluoroethanol.

[0033] S2. After the PLGA is completely dissolved, weigh a certain amount of notoginseng powder (1250 mesh) and add it to the above electrospinning solution, mix and stir evenly. The concentration of notoginseng powder in the electrospinning solution is 1.5% (mass / volume ratio). Put the above solution into a syringe, connect the front tube of the micropump and the spinning needle, and set the electrospinning parameter range as follows: spinning voltage, 25kv; solution propulsion speed, 5mL / h; receiving distance, 18cm. Control the temperature between 20°C and 35°C, and the humidity between 35% and 70%. Start electrospinning to prepare a tissue repair membrane; place the tissue repair membrane in a blast d...

Embodiment 2

[0038] S1. Prepare an electrospinning solution; select 4 g of PLLA with a molecular weight of 250,000, and weigh 0.32 g of notoginseng powder (1250 mesh), mix the two evenly, and add them to a conical flask containing 10 mL of hexafluoroisopropanol, Add a stir bar and stir on a magnetic stirrer to dissolve.

[0039] S2. After the PLLA is completely dissolved, put the above solution into the syringe, connect the front tube of the micropump and the spinning needle, and set the electrospinning parameter range as follows: spinning voltage, 19kv; solution propulsion speed, 3.5mL / h ; Receiving distance, 19cm. Control the temperature between 20°C and 35°C, and the humidity between 35% and 70%. Start the electrospinning to prepare the tissue repair membrane; place the tissue repair membrane in a blast drying oven for heat treatment to remove most of the residual solvent, the treatment temperature is 55°C, and the treatment time is 12h. Soak in alcohol for 1 day, rinse with water for...

Embodiment 3

[0044] S1. Prepare an electrospinning solution; select PVDF with a viscosity of 1.9dl / g, and prepare a solution with a mass concentration of 20%, and the selected solvent is a mixed solvent (acetone:DMF=6:4). After soaking and swelling for 16 hours, heat to 75°C, stir and dissolve for 1 hour, stop heating, and cool down to room temperature.

[0045]S2. Add notoginseng powder (1250 mesh) to the above electrospinning solution, mix and stir evenly. The mass ratio of Panax notoginseng powder and PVDF in the mixed solution is 8:100. Put the above solution into a syringe, connect the front tube of the micropump and the spinneret, and set the electrospinning parameter range as follows: spinning voltage, 28kv; solution propulsion speed, 8mL / h; receiving distance, 23cm. Control the temperature between 20°C and 35°C, and the humidity between 35% and 70%. Start the electrospinning to prepare the tissue repair membrane; place the tissue repair membrane in a blast drying oven for drying ...

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Abstract

The invention discloses a panax notoginseng loaded hemostatic tissue repair membrane. The panax notoginseng loaded hemostatic tissue repair membrane comprises a hemostatic layer and a tissue membrane repair layer, wherein the hemostatic layer is prepared by mixing panax notoginseng and / or dencichine with natural high polymer materials; the tissue membrane repair layer is prepared by performing electrostatic spinning on panax notoginseng and / or dencichine and an electrostatic spinning material for tissue repair; and in the tissue membrane repair layer, the panax notoginseng and / or dencichine accounts for 5-30 percent of the mass of the tissue membrane repair layer. The tissue repair membrane disclosed by the invention has a good hemostatic function, is conveniently operated by a doctor, realizes hemostasis, does not influence the original repair effect of the tissue repair membrane and is particularly suitable for repairing tissues of easily bleeding parts.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a hemostatic tissue repair film loaded with notoginseng and a preparation method thereof. Background technique [0002] In the fields of treating human trauma and repairing organs, it is usually necessary to use surgical implants to assist. Most of the existing surgical implants are made of tissue repair materials prepared by electrospinning of polymer materials. Although these tissue repair materials have the characteristics of good permeability, high porosity, softness, and easy fit, they can promote tissue or tissue repair. However, the vast majority of surgical implants, such as dura mater patch, hernia patch, dermal graft, etc., often need to clean the wound and stop bleeding when implanted in the human body to ensure that the implant can be compatible with the The wounds are tightly bonded together, and for some bleeding-prone parts, the time for hemostasis and wound...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/20A61L27/22A61L27/24A61L27/16A61L27/18
Inventor 詹泽丰周家明朱琳徐弢袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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