7 results about "Hyperactive bladder" patented technology

1. Name of the design product: tibial nerve stimulator main machine. 2. Use of the design product: used for discharging tibial nerve to treat overactive bladder and other diseases; or used for stimulating discharge of other nerves. 3. Design points of the design product: in shape. 4. Pictures or photos that best show the design points: perspective view 1.

A method of implanting a nerve stimulation device in treating an overactive bladder condition includes providing an external programmer and providing an implantable tibial nerve stimulation device (ITNS device) including a pulse generator enclosing circuitry and a lead coupling an electrode assembly to the pulse generator. The external programmer wirelessly communicates with the circuitry of the pulse generator to program a stimulation therapy for the ITNS device.

The invention relates to the field of antibodies, in particular to a monoclonal antibody for treating overactive bladder and application of the monoclonal antibody. The monoclonal antibody specifically recognizes and is combined with an adrenergic receptor beta3 (ADR beta3), the monoclonal antibody is obtained through a hybridoma technology, and the M13 monoclonal antibody with high affinity is successfully screened out. The M13 antibody promotes the increase of cAMP concentration in smooth muscle cells and activates a PKA pathway by activating an ADR beta3 receptor, thereby promoting the relaxation of bladder smooth muscles, increasing the bladder capacity and reducing the non-autonomous contraction of detrusor muscles. Animal experiments prove that the M13 monoclonal antibody can effectively improve the urination frequency and urine volume of a mouse OAB model, and has a good clinical application prospect. The monoclonal antibody and the preparation method thereof can be widely applied to the field of treatment of overactive bladder.

The present invention relates to novel pyrrolidinium compounds, stereoisomers, hydrates or solvates thereof, which exhibit excellent binding capacity and antagonistic activity to muscarinic receptors, in particular muscarinic M3 receptors. The compounds of the present invention are useful in the treatment of muscarinic acetylcholine receptor mediated diseases, such as hyperhidrosis, excessive salivation, chronic obstructive pulmonary disease, chronic bronchitis, asthma, rhinitis, urinary incontinence, overactive bladder, gastroesophageal reflux disease, irritable bowel syndrome, and the like.

The invention provides a method of diagnosing overactive bladder disorder (OAB), the method comprising: measuring the concentrations of one or more of adenosine triphosphate (ATP), acetylcholine (ACh), nitric oxide (NO) and interleukin 5 (IL-5) in a sample obtained from a subject; normalising the concentrations to the concentration of creatinine (Cr) in the sample; range standardising the normalised concentrations and subject's age to the following values: Age to 120 years old; ATP / Cr to 0.000001; ACh / Cr to 0.1; NO to 20000; IL-5 / Cr to 100; wherein the likelihood of having OAB (pOAB)=1 / 1+e−x, where X=one or more of the following: (a) (−2.688±1.050)+5.472±2.098×subject's age+1.356±0.559×Gender (Female=1, Male=0)+(−7.998±40.273)×[IL-5 / Cr]; (b) (−2.141±0.966)+4.506±1.902×subject's age+1.034±0.519×Gender (Female=1, Male=0)+(−5294.063±9075.456)×[ACh / Cr]; (c) (−2.825±1.072)+5.964±2.167×subject's age+1.312±0.562×Gender (Female=1, Male=0)+17.790±58.762×[IL-5 / Cr]+(−9180.821±12700.057)×[ACh / Cr]; (d) (−2.993±1.197)+5.580±2.309×subject's age+1.724±0.719×Gender (Female=1, Male=0)+63.571±73.444×[IL-5 / Cr]+(−0908.523±13606.752)×[ACh / Cr]+(−566.991±636.589)×[ATP / Cr]; (e) (−3.090±1.200)+5.393±2.256×subject's age+1.797±0.717×Gender (Female=1, Male=0)+34.767±56.331×[IL-5 / Cr]+(−562.743±629.316)×[ATP / Cr]; or (f) (−2.650±1.067)+5.516±2.120×subject's age+1.389±0.583×Gender (Female=1, Male=0)+(−4.060±45.238)×[IL-5 / Cr]+(−1.456±6.833)×[NO / Cr]; and wherein a pOAB above a threshold indicates that the subject has a high likelihood of having or developing OAB and a pOAB below a threshold indicates that the subject does not have OAB.

A system for modulating bladder function is disclosed. A system for evaluating the electrophysiological function of a bladder is disclosed. Methods for performing a controlled surgical procedure on a bladder are disclosed. A system for performing controlled surgical procedures in a minimally invasive manner is disclosed. An implantable device for monitoring and / or performing a neuromodulation procedure on a bladder is disclosed.

The application discloses a traditional Chinese medicine composition for treating overactive bladder (OAB) with kidney yang deficiency, a preparation method and application thereof. The composition is composed of three medicinal materials of fennel, cherokee rose and stir-baked dodder seed, and is formulated according to an optimal ratio. The composition improves the symptoms of frequent urination caused by OAB according to the TCM syndrome differentiation and treatment concept. The composition has the advantages of simple prescription, exact curative effect, no obvious toxic and side effects, simple medicine, easy quality control, low cost, reduced medical burden of patients, saved traditional Chinese medicine resources, and the like. The composition can obviously improve the urination indexes, OABSS scores and TCM syndrome scores of patients, improve the life quality of patients, has few adverse reactions, good tolerance and no drug dependence, and can significantly repair the bladder function of model rats and reduce the urination frequency. The product is prepared by adopting a volatile oil inclusion, alcohol extraction and water extraction combination and spray drying granulation process. The product contains 42 kinds of chemical components, mainly flavones and phenolic acids, has obvious comprehensive advantages, and has good industrialization and clinical application prospects.