23 results about "TRPV1 receptor" patented technology

The invention discloses a salty taste enhancing peptide. The amino acid sequence of the salty taste enhancing peptide is YD, VR, DA, RVR or any one of SEQ ID NO: 1 to SEQ ID NO: 12. The salty taste enhancing peptide is derived from the part with the molecular weight smaller than or equal to 3000Da in substances obtained after enzymolysis of soft-shelled turtle eggs, has excellent binding energy with salty taste receptors ENaC receptor, TRPV1 receptor and TMC4 receptor and can be tightly combined with the salty taste receptors, a salty taste enhancing peptide solution with the concentration of 0.1% (g / mL) has a remarkable salty taste enhancing effect on a NaCl solution, salty taste sense can be effectively adjusted, and the salty taste enhancing peptide can be used for improving the salty taste of the soft-shelled turtle eggs. Therefore, the salt intake is reduced, the salty taste is not reduced, and the purposes of reducing salt and not reducing salty taste are achieved.

The invention provides a polypeptide and application thereof in preparation of a TRPV1 inhibitor, and particularly belongs to the technical field of biomedicine. The invention provides a polypeptide which is named as Cath2, and the amino acid sequence of the polypeptide is as shown in SEQ ID NO. 1. The Cath2 can significantly inhibit activation of a TRPV1 ion channel of a mammal, inhibits TRPV1 receptors of other species including human beings in a targeted manner, and can be applied to research of TRPV1-related ion channel diseases and development of drugs. Specifically, the composition can enhance the resistance of mammals to pruritus and pain, can be used as a resource to be developed into an itching relieving product or an analgesic product and the like, and is applied to human beings and other animals to relieve pruritus and pain.

This invention relates to a pufferfish TRPV1 inhibitory peptide, its preparation method, and its application. The amino acid sequence of the peptide is LDIF. The preparation method includes: 1. Enzymatically hydrolyzing pufferfish skin, then inactivating the enzyme, and screening for peptides with a molecular weight not greater than 1 kDa from the hydrolysate, followed by freeze-drying to obtain the pufferfish skin enzymatic hydrolysate peptide; 2. Performing mass spectrometry analysis on the pufferfish skin enzymatic hydrolysate peptide, using mass spectrometry analysis software, and selecting multiple non-repeating peptide sequences based on the criteria of confidence level -10lgP > 20 and amino acid count < 10; 3. Molecularly docking the selected peptide sequences with the TRPV1 receptor using software to select peptide sequences with strong binding affinity to the TRPV1 receptor; 4. Solid-phase synthesis of the selected peptide sequences to obtain the peptide LDIF. This invention uses pufferfish skin as raw material to obtain a peptide with good inhibitory effect on TRPV1, which can be used to prepare skin care products for soothing sensitive skin.

The invention relates to the technical field of soothing and repairing cosmetics, in particular to a soothing and repairing mirabilis jalapa liposome composition, a mask liquid and a preparation method and application of the soothing and repairing mirabilis jalapa liposome composition and the mask liquid. The composition comprises a saussurea involucrata liposome, a triple ceramide liposome and a dihydroavena alkaloid liposome, wherein the weight ratio of the saussurea involucrata liposome to the triple ceramide liposome to the dihydroavena alkaloid liposome is (1-8): (1-5): (1-7); the particle size of the mirabilis jalapa liposome is 50 to 150 nm; the particle size of the triple ceramide liposome is 100 to 200 nm; the particle size of the dihydrooat alkaloid liposome is 100 to 200 nm. According to the invention, specific active components are selected and compounded in a liposome form, so that a synergistic regulation effect can be realized, the expression of a TRPV1 receptor and inflammatory factors is remarkably inhibited, and a good soothing and repairing effect is further realized.

This invention discloses a post-medical aesthetic repair and soothing composition, its preparation method, and its application, relating to the field of cosmetic technology. The invention provides a repair and soothing composition comprising the following components in parts by weight: 0.1-1 parts citrus fruit extract, 0.1-0.5 parts date palm fruit extract, 0.05-0.5 parts gentian root extract, and 0.1-1 parts liposomes; wherein the liposomes comprise dipotassium glycyrrhizate and phytol. The repair and soothing composition provided by this invention achieves rapid repair and long-term stabilization through a multi-dimensional synergistic mechanism. The above-mentioned composition of this invention synergistically regulates skin pH, instantly blocks the transmission of neurogenic pain signals mediated by TRPV1 receptors, synergistically rebuilds the physical and microecological barriers, promotes vasoconstriction, and activates skin TRPM cold receptors, achieving the effect of a "cold compress."

The invention discloses an application of a mikania micrantha extract in preparation of a medicine for antagonizing TRPA1 and / or TRPV1 receptors. The research shows that the mikania micrantha extract has the effect of antagonizing a TRPA1 receptor or a TRPV1 receptor, also has the activity of antagonizing the TRPA1 receptor and the TRPV1 receptor, and can improve the symptom reaction of a model animal constructed by a specific TRPA1 receptor stimulant or a TRPV1 receptor stimulant, block the combination of the stimulant and the receptor, and inhibit the stimulant from playing a biological effect. Meanwhile, both the volatile oil extract and the aqueous extract of the mikania micrantha have better antagonistic effects which are equivalent to those of positive drugs, and have better antagonistic activity as a transient receptor potential (TRP) receptor antagonist, so that more methods and bases are provided for preparing more natural, safe and efficient drugs for antagonizing TRPA1 and / or TRPV1 receptors.

The present invention belongs to the technical field of biomedicine. Disclosed is an asiatic-acid-derived ceramide, which has the structure of general formula (I) or an isomer of general formula I, wherein R1 is selected from one of the following structures in (II), and R2 is hydroxyl or a hydrogen atom. Further disclosed in the present invention are a method for synthesizing the asiatic-acid-derived ceramide and the use thereof. By means of the present invention, the solubility of ceramide is improved by means of introducing an asiatic acid or madecassic acid fragment with good fat solubility, thereby facilitating the use of ceramide in formulations. The compound of the present invention exhibits a significant inhibitory effect on inflammatory cytokine interleukin-6 (IL-6), and can also suppress the overexpression of TRPV1 receptors in sensitive skin and significantly reduce the expression of hyaluronidase, thereby achieving a good soothing effect.

This document presents a novel composition and method for treating osteoarthritis using a cannabinoid-based nanoplatform administered via intra-articular injection. The composition includes phytocannabinoids such as CBG and CBC, along with hyaluronic acid, type II collagen, and calcium gluconate, embedded within a nanoplatform designed to enhance bioavailability and ensure controlled release in the synovial space. Tailored for osteoarthritis patients, the treatment alleviates joint pain, stiffness, reduced mobility, inflammation, sensations of friction, muscle weakness, and joint deformity. Cannabinoids act through multiple mechanisms, including interaction with CB1 and CB2 receptors, cytokine modulation, inhibition of NF-κB, and activation of the TRPV1 receptor, providing a potent anti-inflammatory effect. The formulation aims to halt cartilage degeneration, reduce pain, and slow osteoarthritis progression. The production process uses nanoemulsification techniques to create particles smaller than 200 nm, with pre-sterilization through membrane filtration, ensuring both efficacy and safety.

The present invention relates to a benzimidazolone-based cinnamamide derivative as a TRPV1 antagonist and a pharmaceutical composition for treating or preventing pain containing the same as an active ingredient. The example compounds provided in one aspect of the present invention block the activation of TRPV1 caused by capsaicin, a TRPV1 receptor activator, but induce appropriate inhibition at approximately pH 20% to 80%, thereby the compounds have pain-relieving effects and effectively reduce side effects such as abnormal body temperature.

The present disclosure is directed to methods of cleansing, decontaminating and / or treating an affected area (such as the mouth, skin, hair, fur, nose, one or both eyes or combinations thereof) of a subject that has been exposed to a chemical irritant such as a cyanocarbon, a capsaicin, an oleoresin Capsicum or a vanilloid which binds to a TRPV1 receptor by applying to the affected area (e.g., mouth, skin, hair fur, nose, one or both eyes or combinations thereof), a cleansing, decontaminating and / or effective amount of a composition that comprises at least one salt, at least one zwitterionic surfactant, at least one quaternary ammonium compound, at least one reducing agent and water to decontaminate the affected area.

The present invention discloses a trans-4-tert-butyl cyclohexanol-L-lactate compound and its application, having the structural formula: The compound has significant TRPV1 receptor antagonism and good skin permeability, and can be used as a skin irritation soothing agent in the preparation of cosmetics or medicines.

The invention discloses a trans-4-tert-butyl cyclohexanol-L-lactate compound and application thereof. The structural formula of the trans-4-tert-butyl cyclohexanol-L-lactate compound is # imgabs0 #. The compound has a remarkable TRPV1 receptor antagonism effect and good skin permeability, and can be used as a skin irritation relieving agent for preparing cosmetics or drugs.

The invention discloses a TRPV1 inhibition type soothing and repairing plant composition. The composition comprises a silybum marianum extract and a Chinese herbaceous peony extract, in the composition, the mass ratio of the Chinese herbaceous peony extract to the silybum marianum extract is (0.1-5): 1. The invention also discloses application of the composition and an external preparation containing the composition. According to the TRPV1 inhibition type soothing and repairing plant composition based on the silybum marianum extract and the paeonia lactiflora extract, a TRPV1 receptor can be specifically inhibited, and meanwhile, neurogenic and immune inflammation pathways are intervened, so that sensitive skin is efficiently relieved.

The invention discloses an oil-controlling and soothing composite extract and a preparation method thereof, and particularly relates to the technical field of cosmetics, the composite extract is composed of 5-10% of a purslane extract, 3-10% of a swertia extract, 0.5-1% of a sophora flavescens extract, 1-5% of an oil-controlling active component, 40-50% of butanediol and the balance of water. The preparation method comprises the following steps: weighing extract powder of each component, heating butanediol, sequentially adding each extract, stirring and dissolving, adding the oil-control active component, homogenizing, and finally filtering and sterilizing. The compound extract achieves the dual effects of relieving, resisting allergy and controlling oil by synergistically inhibiting a TRPV1 receptor, regulating inflammatory factor expression and regulating sebum secretion, can be applied to skin care products such as essence, emulsion and masks, has the addition amount of 0.5%-5%, has remarkable effects in the aspects of oil control, relieving and the like, is mild and non-irritant, and is suitable for various skin types.

The invention provides an anti-allergy repairing composition containing lindera aggregata and andrographis paniculata as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The technical problem to be solved is to provide the cosmetic containing the lindera aggregata and the andrographis paniculata, which has repairing and anti-allergy effects and is simple and safe in components. The key points of the technical scheme are as follows: 1) a preparation method of a lindera aggregata extract and an andrographis paniculata extract; 2) a lindera aggregata extract and an andrographis paniculata extract in a specific ratio; and 3) application of the composition containing the lindera aggregata extract and the andrographis paniculata extract in anti-allergy repair cosmetics. The components are extracted from Chinese herbal medicines, and the components are simple, so that the traditional Chinese medicine composition is safer to use. Meanwhile, a good anti-allergy effect can be achieved by inhibiting TRPV1 receptor activation, HaCaT cells can be promoted to express FLG and LOR, and a remarkable repairing effect is achieved.

The invention relates to the technical field of skin care, in particular to a plant extract for inhibiting TRPV1 receptors and relieving and a preparation method thereof.The plant extract is prepared by extracting portulaca oleracea, rosemary leaves and citrus peel according to the weight ratio of (1-3): (1-5): (0.1-0.2), and the citrus peel is dried peel of sweet oranges, grapefruits or lemons. The preparation method comprises the steps of raw material pretreatment, extraction solvent preparation, extraction and post-treatment, according to the plant extract capable of inhibiting the TRPV1 receptor and relieving and the preparation method thereof, the purslane, the rosemary leaves and the citrus peel are combined according to the specific weight ratio of (1-3): (1-5): (0.1-0.2), flavone and alkaloid in the purslane, carnosic acid and rosmarinic acid in the rosemary, carnosic acid and rosmarinic acid in the rosemary and the citrus peel are mixed, and the TRPV1 receptor inhibiting and relieving plant extract is obtained. Three active ingredients of polymethoxylated flavonoids in the citrus peel form a synergistic effect, so that activation of a key receptor TRPV1 of skin itch and stabbing pain is directly inhibited from the upstream, neurogenic inflammation is blocked from the source, expression of core inflammatory factors such as TNF-alpha and IL-6 is synergistically inhibited from the downstream, and the effect of the composition is superior to that of a single plant extract and a mixture with a non-optimal ratio.

The present invention belongs to the technical field of biomedicine, and discloses a ceramide derived from asiatic acid, which has the structure of general formula I or an isomer of general formula I: wherein, R<supgt;1< / supgt> is selected from one of the following structures: R<supgt;2< / supgt> is a hydroxyl group or a hydrogen atom. The present invention also discloses a synthesis method and application of the ceramide derived from asiatic acid. By introducing a lipophilic asiatic acid or asiaticoside fragment, the solubility of the ceramide is improved, making its application in formulations more convenient; the compound of the present invention has an obvious inhibitory effect on the interleukin 6 (IL-6) inflammatory factor, can also inhibit the overexpression of the TRPV1 receptor in sensitive skin, and can significantly reduce the expression of hyaluronidase, thus having a good soothing effect.

The invention relates to application of a TRPV1 receptor agonist or inhibitor and a low-temperature protective agent. Compared with the prior art, the TRPV1 receptor stimulant or inhibitor is added into the preserving fluid, so that the damage problem of cells and tissues in the low-temperature preservation process of 4 DEG C is remarkably reduced, and the TRPV1 receptor stimulant or inhibitor can protect the integrity of cell membranes of various cells and reduce lysis caused by low-temperature preservation; the protection performance of the preserving fluid is improved, and the low-temperature storage life of cells and tissues is prolonged; and the TRPV1 receptor agonists such as capsaicin are natural compounds, have low toxicity and are suitable for wide application. The method is easy to operate, raw materials are easy to obtain, and preparation and use in various common biology laboratories and clinics are facilitated.

The invention belongs to the technical field of cosmetics, and discloses a composition for inhibiting TRPV1 activation and a preparation method and application thereof. The composition disclosed by the invention comprises a glycyrrhiza inflata root extract and licochalcone B, wherein the glycyrrhiza inflata root extract is prepared by carrying out enzymolysis and alcohol extraction on glycyrrhiza inflata roots. The glycyrrhiza inflata root extract and licochalcone B are combined, so that the composition has synergistic interaction and low onset concentration, can effectively inhibit TRPV1 activation, specifically, can inhibit expression of a TRPV1 receptor and inhibit calcium ion influx after TRPV1 activation, especially has a remarkable inhibition effect on TRPV1 activation induced by pungent components such as capsaicin and phenol compounds, and has a good application prospect. The TRPV1 antagonist is superior to the traditional TRPV1 antagonist (AMG9810).

Provided herein are compounds and pharmaceutical compositions useful for treating diseases or disorders mediated by the TRPV1 receptor. The present invention also provides methods for treating ocular diseases or disorders by administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I) or a pharmaceutical composition described herein.

The invention relates to a puffer fish TRPV1 inhibitory peptide as well as a preparation method and application thereof. The amino acid sequence of the peptide is LDIF. The preparation method comprises the following steps: 1, performing enzymolysis on the fish skin of the puffer fish, performing enzyme deactivation, then screening out polypeptide with the molecular weight not greater than 1kDa from enzymatic hydrolysate, and performing freeze-drying to obtain the puffer fish skin enzymolysis polypeptide; 2, performing mass spectrum determination on the puffer fish skin enzymolysis polypeptide, analyzing a mass spectrum determination result by adopting mass spectrum analysis software, and screening out a plurality of non-repeated polypeptide sequences under the screening conditions that the credibility-10lgP is greater than 20 and the number of amino acids is less than 10; 3, carrying out molecular docking on the screened polypeptide sequence and the TRPV1 receptor through software, and screening the polypeptide sequence with strong binding capacity with the TRPV1 receptor; and 4, performing solid-phase synthesis on the screened polypeptide sequence to obtain the polypeptide LDIF. According to the invention, the puffer fish skin is used as a raw material to obtain the polypeptide with a good inhibition effect on TRPV1, and the polypeptide can be used for preparing a skin care product for relieving sensitive skin.

The invention discloses a composition for post-art repairing and relieving as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The invention provides a composition for repairing and relieving. The composition is prepared from the following components in parts by weight: 0.1 to 1 part of citrus fruit extract, 0.1 to 0.5 part of phoenix fruit extract, 0.05 to 0.5 part of radix gentianae extract and 0.1 to 1 part of lipidosome, the liposome is prepared from dipotassium glycyrrhizinate and phytol. The composition for repairing and relieving provided by the invention realizes rapid repairing and long-acting stability maintenance through a multi-dimensional synergistic mechanism. The composition disclosed by the invention can be used for dynamically regulating the pH value of the skin in a synergetic manner, immediately blocking neurogenic pain signal conduction mediated by a TRPV1 receptor, synergistically reconstructing a physical barrier and a micro-ecological barrier, promoting vasoconstriction and activating a skin TRPM skin cold feeling body so as to achieve the effect of'cold compress'.

The present application provides an efficacy composition for essence oil or body care oil, comprising ceramide or its analog, cholesterol or its analog, fatty acid, an antagonist of TRPV1 receptor, triglyceride substances, a sebum wax ester structure analog, and squalene. It aims to prepare an essence oil product with a light texture, weak greasiness, and a comprehensive and effective soothing and repairing effect on sensitive skin problems.