9 results about "TRPV1 receptor" patented technology

The invention provides a polypeptide and application thereof in preparation of a TRPV1 inhibitor, and particularly belongs to the technical field of biomedicine. The invention provides a polypeptide which is named as Cath2, and the amino acid sequence of the polypeptide is as shown in SEQ ID NO. 1. The Cath2 can significantly inhibit activation of a TRPV1 ion channel of a mammal, inhibits TRPV1 receptors of other species including human beings in a targeted manner, and can be applied to research of TRPV1-related ion channel diseases and development of drugs. Specifically, the composition can enhance the resistance of mammals to pruritus and pain, can be used as a resource to be developed into an itching relieving product or an analgesic product and the like, and is applied to human beings and other animals to relieve pruritus and pain.

This invention relates to a pufferfish TRPV1 inhibitory peptide, its preparation method, and its application. The amino acid sequence of the peptide is LDIF. The preparation method includes: 1. Enzymatically hydrolyzing pufferfish skin, then inactivating the enzyme, and screening for peptides with a molecular weight not greater than 1 kDa from the hydrolysate, followed by freeze-drying to obtain the pufferfish skin enzymatic hydrolysate peptide; 2. Performing mass spectrometry analysis on the pufferfish skin enzymatic hydrolysate peptide, using mass spectrometry analysis software, and selecting multiple non-repeating peptide sequences based on the criteria of confidence level -10lgP > 20 and amino acid count < 10; 3. Molecularly docking the selected peptide sequences with the TRPV1 receptor using software to select peptide sequences with strong binding affinity to the TRPV1 receptor; 4. Solid-phase synthesis of the selected peptide sequences to obtain the peptide LDIF. This invention uses pufferfish skin as raw material to obtain a peptide with good inhibitory effect on TRPV1, which can be used to prepare skin care products for soothing sensitive skin.

The invention relates to the technical field of soothing and repairing cosmetics, in particular to a soothing and repairing mirabilis jalapa liposome composition, a mask liquid and a preparation method and application of the soothing and repairing mirabilis jalapa liposome composition and the mask liquid. The composition comprises a saussurea involucrata liposome, a triple ceramide liposome and a dihydroavena alkaloid liposome, wherein the weight ratio of the saussurea involucrata liposome to the triple ceramide liposome to the dihydroavena alkaloid liposome is (1-8): (1-5): (1-7); the particle size of the mirabilis jalapa liposome is 50 to 150 nm; the particle size of the triple ceramide liposome is 100 to 200 nm; the particle size of the dihydrooat alkaloid liposome is 100 to 200 nm. According to the invention, specific active components are selected and compounded in a liposome form, so that a synergistic regulation effect can be realized, the expression of a TRPV1 receptor and inflammatory factors is remarkably inhibited, and a good soothing and repairing effect is further realized.

The invention discloses an application of a mikania micrantha extract in preparation of a medicine for antagonizing TRPA1 and / or TRPV1 receptors. The research shows that the mikania micrantha extract has the effect of antagonizing a TRPA1 receptor or a TRPV1 receptor, also has the activity of antagonizing the TRPA1 receptor and the TRPV1 receptor, and can improve the symptom reaction of a model animal constructed by a specific TRPA1 receptor stimulant or a TRPV1 receptor stimulant, block the combination of the stimulant and the receptor, and inhibit the stimulant from playing a biological effect. Meanwhile, both the volatile oil extract and the aqueous extract of the mikania micrantha have better antagonistic effects which are equivalent to those of positive drugs, and have better antagonistic activity as a transient receptor potential (TRP) receptor antagonist, so that more methods and bases are provided for preparing more natural, safe and efficient drugs for antagonizing TRPA1 and / or TRPV1 receptors.

The present invention belongs to the technical field of biomedicine. Disclosed is an asiatic-acid-derived ceramide, which has the structure of general formula (I) or an isomer of general formula I, wherein R1 is selected from one of the following structures in (II), and R2 is hydroxyl or a hydrogen atom. Further disclosed in the present invention are a method for synthesizing the asiatic-acid-derived ceramide and the use thereof. By means of the present invention, the solubility of ceramide is improved by means of introducing an asiatic acid or madecassic acid fragment with good fat solubility, thereby facilitating the use of ceramide in formulations. The compound of the present invention exhibits a significant inhibitory effect on inflammatory cytokine interleukin-6 (IL-6), and can also suppress the overexpression of TRPV1 receptors in sensitive skin and significantly reduce the expression of hyaluronidase, thereby achieving a good soothing effect.

This document presents a novel composition and method for treating osteoarthritis using a cannabinoid-based nanoplatform administered via intra-articular injection. The composition includes phytocannabinoids such as CBG and CBC, along with hyaluronic acid, type II collagen, and calcium gluconate, embedded within a nanoplatform designed to enhance bioavailability and ensure controlled release in the synovial space. Tailored for osteoarthritis patients, the treatment alleviates joint pain, stiffness, reduced mobility, inflammation, sensations of friction, muscle weakness, and joint deformity. Cannabinoids act through multiple mechanisms, including interaction with CB1 and CB2 receptors, cytokine modulation, inhibition of NF-κB, and activation of the TRPV1 receptor, providing a potent anti-inflammatory effect. The formulation aims to halt cartilage degeneration, reduce pain, and slow osteoarthritis progression. The production process uses nanoemulsification techniques to create particles smaller than 200 nm, with pre-sterilization through membrane filtration, ensuring both efficacy and safety.

The invention discloses a TRPV1 inhibition type soothing and repairing plant composition. The composition comprises a silybum marianum extract and a Chinese herbaceous peony extract, in the composition, the mass ratio of the Chinese herbaceous peony extract to the silybum marianum extract is (0.1-5): 1. The invention also discloses application of the composition and an external preparation containing the composition. According to the TRPV1 inhibition type soothing and repairing plant composition based on the silybum marianum extract and the paeonia lactiflora extract, a TRPV1 receptor can be specifically inhibited, and meanwhile, neurogenic and immune inflammation pathways are intervened, so that sensitive skin is efficiently relieved.

The invention relates to the technical field of skin care, in particular to a plant extract for inhibiting TRPV1 receptors and relieving and a preparation method thereof.The plant extract is prepared by extracting portulaca oleracea, rosemary leaves and citrus peel according to the weight ratio of (1-3): (1-5): (0.1-0.2), and the citrus peel is dried peel of sweet oranges, grapefruits or lemons. The preparation method comprises the steps of raw material pretreatment, extraction solvent preparation, extraction and post-treatment, according to the plant extract capable of inhibiting the TRPV1 receptor and relieving and the preparation method thereof, the purslane, the rosemary leaves and the citrus peel are combined according to the specific weight ratio of (1-3): (1-5): (0.1-0.2), flavone and alkaloid in the purslane, carnosic acid and rosmarinic acid in the rosemary, carnosic acid and rosmarinic acid in the rosemary and the citrus peel are mixed, and the TRPV1 receptor inhibiting and relieving plant extract is obtained. Three active ingredients of polymethoxylated flavonoids in the citrus peel form a synergistic effect, so that activation of a key receptor TRPV1 of skin itch and stabbing pain is directly inhibited from the upstream, neurogenic inflammation is blocked from the source, expression of core inflammatory factors such as TNF-alpha and IL-6 is synergistically inhibited from the downstream, and the effect of the composition is superior to that of a single plant extract and a mixture with a non-optimal ratio.

The invention belongs to the technical field of cosmetics, and discloses a composition for inhibiting TRPV1 activation and a preparation method and application thereof. The composition disclosed by the invention comprises a glycyrrhiza inflata root extract and licochalcone B, wherein the glycyrrhiza inflata root extract is prepared by carrying out enzymolysis and alcohol extraction on glycyrrhiza inflata roots. The glycyrrhiza inflata root extract and licochalcone B are combined, so that the composition has synergistic interaction and low onset concentration, can effectively inhibit TRPV1 activation, specifically, can inhibit expression of a TRPV1 receptor and inhibit calcium ion influx after TRPV1 activation, especially has a remarkable inhibition effect on TRPV1 activation induced by pungent components such as capsaicin and phenol compounds, and has a good application prospect. The TRPV1 antagonist is superior to the traditional TRPV1 antagonist (AMG9810).