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Solifenacin succinate-containing orally disintegrating tablet and preparation method thereof

A technology of solifenacin succinate and oral disintegrating tablets, which is applied in the directions of active ingredients of heterocyclic compounds, pill delivery, urinary system diseases, etc., can solve problems such as affecting life and work, affecting the quality of life of patients, etc. , Increase the process reproducibility, the effect of less dust pollution

Inactive Publication Date: 2014-02-19
BEIJING VENTUREPHARM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Overactive bladder brings a lot of inconvenience to the life of the patient, which will greatly affect the quality of life of the patient, and even affect the daily life and work

Method used

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  • Solifenacin succinate-containing orally disintegrating tablet and preparation method thereof
  • Solifenacin succinate-containing orally disintegrating tablet and preparation method thereof
  • Solifenacin succinate-containing orally disintegrating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The existence form of this embodiment is a tablet. (Calculated per 1000 pieces)

[0024]

[0025] Preparation process: Mix the active ingredients in the prescription, solinacine succinate, microcrystalline cellulose PH102, and crospovidone XL-10, pass through an 80-mesh sieve 3 times, after mixing, add water, grind and mix well with a mortar Then, granulate with a 24-mesh sieve. Dry in an oven at 50℃ for 2 hours, and after 30 meshes are granulated, calculate the yield, convert the amount of microcrystalline cellulose PH102, and the amount of crospovidone XL-10, mix for 3 minutes, and then convert silicon dioxide and magnesium stearate The dosage, mix for 1min. Tablets on a rotary tablet press.

Embodiment 2

[0027] The existence form of this embodiment is a tablet. (Calculated per 1000 pieces)

[0028]

[0029] Preparation process: Mix the active ingredients in the prescription, solinacine succinate, microcrystalline cellulose PH102, and crospovidone XL-10, pass through an 80-mesh sieve 3 times, after mixing, add water, grind and mix well with a mortar Then, granulate with a 24-mesh sieve. Dry in an oven at 50°C for 2 hours, and after 30 meshes are granulated, calculate the yield, convert the amount of microcrystalline cellulose PH102, and the amount of crospovidone XL-10, mix for 3 minutes, and then convert silica and magnesium stearate The dosage, mix for 1min. Tablets on a rotary tablet press.

Embodiment 3

[0031] The existence form of this embodiment is a tablet. (Calculated per 1000 pieces)

[0032]

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Abstract

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a solifenacin succinate-containing orally disintegrating tablet and a preparation method thereof. The orally disintegrating tablet is clinically used for treating symptoms such as frequent micturition, urgent urination and urinary incontinence caused by the overactive bladder.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to an orally disintegrating tablet containing solifenacin succinate and a preparation method thereof. Background technique [0002] Overactive Bladder (OAB), referred to as overactive bladder, is a syndrome characterized by urinary urgency symptoms, often accompanied by urinary symptoms, with or without urge urinary incontinence, urodynamically May show detrusor overactivity, but also other forms of urethro-bladder dysfunction. OAB has no clear etiology and does not include symptoms caused by acute urinary tract infection or other forms of localized vesicourethral lesions. Overactive bladder brings a lot of inconvenience to the life of patients, which will greatly affect the quality of life of patients, and even affect their daily life and work. At present, there are mainly several methods for the clinical treatment of overactive bladder: 1. Behavioral training, 2. Drug th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/49A61P13/10
Inventor 吉枫翟志瑞郭夏
Owner BEIJING VENTUREPHARM BIOTECH
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