The application provides a
virtual endoscopy imaging method,
system, device and medium. The method comprises: acquiring multi-
energy level imaging body data of a target object; performing base substance
decomposition processing on the multi-
energy level imaging body data based on a preset base substance combination to generate base substance images corresponding to each base substance; reconstructing a luminal three-dimensional structure model representing a luminal region of the target
object based on the multi-
energy level imaging body data; performing
lesion detection according to the base substance images and the multi-energy level imaging body data to obtain
lesion information and associating the
lesion information with the luminal three-dimensional structure model; performing
endoscopy in the luminal three-dimensional structure model through a virtual
endoscope and generating
visualization information of a check region of the virtual
endoscope in the check region; wherein the
visualization information comprises the check region and / or lesion information in the check region. The application can intuitively observe the lesion position and component information in a dynamic check process.