The invention discloses an asphalt mixture virtual performance test prediction method based on mesoscale simulation. The method comprises the steps of designing an initial mix proportion of an asphalt mixture, acquiring basic parameters of a material, carrying out a DSR test of asphalt mortar, carrying out a virtual creep test on the asphalt mortar, converting parameters in a virtual system, choosing multiple indoor tests needing to be predicted, constructing various three-dimension virtual test pieces, choosing a mechanic constitutive model of the material, choosing a loading condition of the virtual test, constructing a real-time monitoring system for test results, outputting final result prediction values of all the tests, comparing all indexes with standards to judge whether requirements are met, outputting suggesting to reselect a mix proportion if the requirements are not met, and outputting an optimal mix proportion if the requirements are met. According to the method, additional curves of the test results are monitored in real time, the obtained output results are compared to judge whether multiple performance indexes of the mixture to be predicted meet the standard requirements, unnecessary relative-property indoor tests are reduced, and test basis is provided for optimal design of the mix proportion of the asphalt mixture.