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Use of composition comprising Formoterol and Budesonide for prevention or treatment of acute condition of asthma

A composition and an acute technique for preventing or treating acute asthma and/or intermittent asthma and/or incidental chronic asthma, which can solve problems such as negative effects on overall patient compliance

Inactive Publication Date: 2001-07-25
ASTRAZENECA AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore a second drug treatment is necessary and this will negatively affect the overall compliance of the patient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]4.5 parts by weight of formoterol fumarate dihydrate were mixed with 915 parts by weight of lactose monohydrate. The mixture is micronized with a high-pressure air jet mill and then treated according to EP-A-717 616 . 80 parts by weight of micronized budesonide were added to the treated product, mixed and homogenized with a low pressure jet mill. The mixture is spheroidized by the method of EP-A-721 331 and packed into Turbuhaler  in the storage compartment.

Embodiment 2

[0041] 9 parts by weight of formoterol fumarate dihydrate were mixed with 831 parts by weight of lactose monohydrate. The mixture is micronized with a high-pressure air jet mill and then treated according to EP-A-717 616 . 160 parts by weight of micronized budesonide were added to the treated product, mixed and homogenized with a low-pressure jet mill. The mixture is spheroidized by the method of EP-A-721 331 and packed into Turbuhaler  in the storage compartment.

Embodiment 3

[0043] 6 parts by weight of formoterol fumarate dihydrate were mixed with 894 parts by weight of lactose monohydrate. The mixture is micronized with a high-pressure air jet mill and then treated according to EP-A-717 616 . 100 parts by weight of micronized budesonide were added to the treated product, mixed and homogenized with a low pressure jet mill. The mixture is spheroidized by the method of EP-A-721 331 and packed into Turbuhaler  in the storage compartment.

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Abstract

The present invention relates to use of a composition for symptomatic relief, when needed, comprising, in admixture (a) a first active ingredient which is formoterol, a pharmaceutically acceptable salt or solvate thereof or a solvate of such a salt; and (b) a second active ingredient which is budesonide; for the manufacture of a medicament for use in the prevention or treatment of an acute condition of asthma and / or intermittent asthma and / or episodes in chronic asthma. The invention further relates to a method for prevention or treatment of an acute condition of asthma and / or intermittent asthma and / or episodes in chronic asthma by administering, by inhalation, a composition comprising the first and second active ingredients as defined previously.

Description

field of invention [0001] The present invention relates to the application of the composition for relieving symptoms requiring relief in the preparation of occasional medicaments for the prevention or treatment of acute asthma and / or intermittent asthma and / or chronic asthma, containing in the mixture: [0002] (a) a first active ingredient which is formoterol, a pharmaceutically acceptable salt thereof or a solvate thereof or a solvate of said salt; and [0003] (b) The second active ingredient is budesonide. [0004] The invention also relates to a method of preventing or treating acute asthma and / or intermittent asthma and / or chronic asthmatic episodes, comprising administering by inhalation a composition as defined above comprising a first and a second active ingredient. Background of the invention [0005] Despite recent advances in the understanding of asthma and the introduction of potent antiasthmatic drugs, asthma remains an under-understood and often difficult to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/57A61K9/00A61K9/14A61K31/045A61K31/165A61K31/167A61K31/573A61K31/58A61K45/00A61K45/06A61P11/06
CPCA61K9/145A61K45/06A61K31/58A61K9/0075A61P11/00A61P11/06A61P11/08A61K31/165A61K2300/00A61K31/57
Inventor T·埃克斯特伦
Owner ASTRAZENECA AB
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