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Use of composition comprising Formoterol and Budesonide for prevention or treatment of acute condition of asthma

A formoterol and composition technology, which can be applied in the directions of medical preparations containing active ingredients, drug combinations, drug delivery, etc., can solve problems such as negative effects on patients' overall compliance

Inactive Publication Date: 2008-05-28
ASTRAZENECA AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore a second medication is necessary and this will negatively impact the patient's overall compliance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]4.5 parts by weight of formoterol fumarate dihydrate were mixed with 915 parts by weight of lactose monohydrate. The mixture is micronized with a high-pressure air jet mill and then treated according to EP-A-717 616 . 80 parts by weight of micronized budesonide were added to the treated product, mixed and homogenized with a low pressure jet mill. The mixture is spheroidized by the method of EP-A-721 331 and packed into in the storage compartment.

Embodiment 2

[0041] 9 parts by weight of formoterol fumarate dihydrate were mixed with 831 parts by weight of lactose monohydrate. The mixture is micronized with a high-pressure air jet mill and then treated according to EP-A-717 616 . 160 parts by weight of micronized budesonide were added to the treated product, mixed and homogenized with a low-pressure jet mill. The mixture is spheroidized by the method of EP-A-721 331 and packed into in the storage compartment.

Embodiment 3

[0043] 6 parts by weight of formoterol fumarate dihydrate were mixed with 894 parts by weight of lactose monohydrate. The mixture is micronized with a high-pressure air jet mill and then treated according to EP-A-717 616 . 100 parts by weight of micronized budesonide were added to the treated product, mixed and homogenized with a low-pressure jet mill. The mixture is spheroidized by the method of EP-A-721 331 and packed into in the storage compartment.

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PUM

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Abstract

The present invention relates to use of a composition for symptomatic relief, when needed, comprising, in admixture (a) a first active ingredient which is formoterol, a pharmaceutically acceptable salt or solvate thereof or a solvate of such a salt; and (b) a second active ingredient which is budesonide; for the manufacture of a medicament for use in the prevention or treatment of an acute condition of asthma and / or intermittent asthma and / or episodes in chronic asthma. The invention further relates to a method for prevention or treatment of an acute condition of asthma and / or intermittent asthma and / or episodes in chronic asthma by administering, by inhalation, a composition comprising the first and second active ingredients as defined previously.

Description

field of invention [0001] The present invention relates to the application of the composition for relieving symptoms used by patients according to needs in the preparation of occasional medicaments for preventing or treating acute asthma and / or intermittent asthma and / or chronic asthma, and the mixture contains: [0002] (a) a first active ingredient which is formoterol, a pharmaceutically acceptable salt thereof or a solvate thereof or a solvate of said salt; and [0003] (b) The second active ingredient is budesonide. [0004] The invention also relates to a method of preventing or treating acute asthma and / or intermittent asthma and / or chronic asthmatic episodes, comprising administering by inhalation a composition as defined above comprising a first and a second active ingredient. Background of the invention [0005] Despite recent advances in the understanding of asthma and the introduction of potent antiasthmatic drugs, asthma remains an under-understood and often dif...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/57A61K31/165A61P11/00A61K9/00A61K9/14A61K31/045A61K31/167A61K31/573A61K31/58A61K45/00A61K45/06A61P11/06
CPCA61K9/145A61K31/58A61K9/0075A61K45/06A61P11/00A61P11/06A61P11/08A61K31/165A61K2300/00A61K31/57
Inventor T·埃克斯特伦
Owner ASTRAZENECA AB
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