Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Fluorescent viscosity probes with aggregation-induced luminescence properties

A technology of aggregation-induced luminescence and viscosity, which is applied in the direction of luminescent materials, fluorescence/phosphorescence, medical preparations containing active ingredients, etc., to achieve high-sensitivity effects

Active Publication Date: 2018-04-20
THE HONG KONG UNIV OF SCI & TECH
View PDF2 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, they still have room for improvement in sensitivity

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Fluorescent viscosity probes with aggregation-induced luminescence properties
  • Fluorescent viscosity probes with aggregation-induced luminescence properties
  • Fluorescent viscosity probes with aggregation-induced luminescence properties

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0090]The present invention provides a fluorescent viscosity probe with aggregation-induced luminescent properties, comprising one or more aggregation-induced luminescence fluorophores, the skeleton structure of which aggregation-induced luminescence fluorophores is selected from one of the following structures:

[0091]

[0092]

[0093] Wherein, each R group is independently selected from a hydrogen atom, an alkyl group, an unsaturated alkyl group, a heteroalkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, and a heteroaryl group; A chromophore to which a luminescent fluorophore is bound; when the molecular structure is positively charged, its counterion is any anion.

[0094] The present invention provides a fluorescent viscosity probe with aggregation-induced luminescent properties, comprising one or more aggregation-induced luminescence fluorophores, the skeleton structure of which aggregation-induced luminescence fluorophores is selected from o...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to fluorescent viscosity probes with aggregation-induced luminescence properties, applications of the probes in solution viscosity detection, glucose concentration determination, viscosity (free volume) change monitoring during polymerization, and viscosity measurement in cells or mitochondria, and an application method. The probes may consist of one or more aggregation-induced luminescence fluorophores. Compared with commercial DCVJ, the probes have higher viscosity sensitivity. The probes are two-photon-excitable and have specific mitochondrial targeting properties so that the probes can be applied in biological research. In addition, the probes can be used for indicating mitochondrial membrane potentials, quantitatively measuring low-concentration proteins,bacterial imaging, mechanical force-induced fluorescence discoloration materials, and other applications.

Description

technical field [0001] The present invention relates to the synthesis of a series of new highly sensitive fluorescent viscosity probes with aggregation-induced luminescent characteristics and their practical application. Background technique [0002] Viscosity is an important physical parameter. In polymer science, it relates to polymerization reactions, polymer molecular weight, polymer stereoregularity, polymer crosslinking, polymer chain freedom, microphase separation, thermal transitions, degradation, and gel formation The change in free volume of matter is the same. In biological systems, viscosity also plays an important role. For example, viscosity changes in cell membranes correlate with alternating protein levels in cells and other physiological processes, and are implicated in diseases such as atherosclerosis, cellular malignancies, hypercholesterolemia, and diabetes. [0003] In traditional technology, viscosity measurement equipment includes capillary viscomet...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C09K11/06C07D217/04C07D401/04A61K41/00A61P35/00G01N21/64
CPCA61K41/0057C07D217/04C07D401/04C09K11/06C09K2211/1007C09K2211/1011C09K2211/1014C09K2211/1029G01N21/6428
Inventor 唐本忠江美娟
Owner THE HONG KONG UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com