Fluorescent viscosity probes with aggregation-induced luminescence properties

A technology of aggregation-induced luminescence and viscosity, which is applied in the direction of luminescent materials, fluorescence/phosphorescence, medical preparations containing active ingredients, etc., to achieve high-sensitivity effects

Active Publication Date: 2018-04-20
THE HONG KONG UNIV OF SCI & TECH
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  • Fluorescent viscosity probes with aggregation-induced luminescence properties
  • Fluorescent viscosity probes with aggregation-induced luminescence properties
  • Fluorescent viscosity probes with aggregation-induced luminescence properties

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[0090]The present invention provides a fluorescent viscosity probe with aggregation-induced luminescent properties, comprising one or more aggregation-induced luminescence fluorophores, the skeleton structure of which aggregation-induced luminescence fluorophores is selected from one of the following structures:

[0091]

[0092]

[0093] Wherein, each R group is independently selected from a hydrogen atom, an alkyl group, an unsaturated alkyl group, a heteroalkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, and a heteroaryl group; A chromophore to which a luminescent fluorophore is bound; when the molecular structure is positively charged, its counterion is any anion.

[0094] The present invention provides a fluorescent viscosity probe with aggregation-induced luminescent properties, comprising one or more aggregation-induced luminescence fluorophores, the skeleton structure of which aggregation-induced luminescence fluorophores is selected from o...

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Abstract

The present invention relates to fluorescent viscosity probes with aggregation-induced luminescence properties, applications of the probes in solution viscosity detection, glucose concentration determination, viscosity (free volume) change monitoring during polymerization, and viscosity measurement in cells or mitochondria, and an application method. The probes may consist of one or more aggregation-induced luminescence fluorophores. Compared with commercial DCVJ, the probes have higher viscosity sensitivity. The probes are two-photon-excitable and have specific mitochondrial targeting properties so that the probes can be applied in biological research. In addition, the probes can be used for indicating mitochondrial membrane potentials, quantitatively measuring low-concentration proteins,bacterial imaging, mechanical force-induced fluorescence discoloration materials, and other applications.

Description

technical field [0001] The present invention relates to the synthesis of a series of new highly sensitive fluorescent viscosity probes with aggregation-induced luminescent characteristics and their practical application. Background technique [0002] Viscosity is an important physical parameter. In polymer science, it relates to polymerization reactions, polymer molecular weight, polymer stereoregularity, polymer crosslinking, polymer chain freedom, microphase separation, thermal transitions, degradation, and gel formation The change in free volume of matter is the same. In biological systems, viscosity also plays an important role. For example, viscosity changes in cell membranes correlate with alternating protein levels in cells and other physiological processes, and are implicated in diseases such as atherosclerosis, cellular malignancies, hypercholesterolemia, and diabetes. [0003] In traditional technology, viscosity measurement equipment includes capillary viscomet...

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Application Information

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IPC IPC(8): C09K11/06C07D217/04C07D401/04A61K41/00A61P35/00G01N21/64
CPCA61K41/0057C07D217/04C07D401/04C09K11/06C09K2211/1007C09K2211/1011C09K2211/1014C09K2211/1029G01N21/6428
Inventor 唐本忠江美娟
Owner THE HONG KONG UNIV OF SCI & TECH
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