Drug-loaded biopolymer composite nanofiber membrane and preparation method thereof

A composite nanofiber and biopolymer technology, applied in plant fiber, fiber treatment, medical science, etc., can solve the problems of production operation means and post-processing means, and achieve safe biodegradable and biodegradable Absorption, beneficial to wound healing, good sterilization effect

Inactive Publication Date: 2019-01-22
GUANGXI YIDEJIA MEDICAL EQUIP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, it is still a challenge to prepare hydrophilic electrospun fiber membranes with sustained release of antibiotics from gelatin, including the following technical problems: 1. How to prepare hydrophilic spun membranes with stable fiber structures in aqueous solution 2. In the case of wound infection, how to regulate the effective and sustained release of antibiotics; especially for natural polymer materials such as alginic acid and gelatin, it is feasible Simple production operation methods and post-processing methods have not yet been well resolved

Method used

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  • Drug-loaded biopolymer composite nanofiber membrane and preparation method thereof
  • Drug-loaded biopolymer composite nanofiber membrane and preparation method thereof
  • Drug-loaded biopolymer composite nanofiber membrane and preparation method thereof

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Embodiment 1

[0039] The invention provides a method for preparing a drug-loaded biopolymer composite nanofiber membrane, comprising the following steps:

[0040]Step 1, dissolving an acidic mixed solution containing a drug to be loaded and a biopolymer, the biopolymer is composed of oxidized sodium alginate and type B gelatin at a mass ratio of 0.01:1, and the mass concentration of the drug to be loaded is 2 %, the mass concentration of biopolymers in the acidic mixed solution is 5%, the pH of the acidic mixed solution is 2, and the pH is adjusted by using formic acid or acetic acid, which is because it is a volatile acidic organic solvent, which is convenient for post-drying can be volatilized;

[0041] Step 2, loading the acidic mixed solution into the feeding device of the electrospinning equipment, and performing electrospinning to prepare a composite polymer nanofiber membrane;

[0042] Step 3: Soak the composite polymer nanofiber membrane in an alkaline ethanol solution with a gradu...

Embodiment 2

[0047] The invention provides a method for preparing a drug-loaded biopolymer composite nanofiber membrane, comprising the following steps:

[0048] Step 1, dissolving an acidic mixed solution containing a drug to be loaded and a biopolymer, the biopolymer is composed of oxidized sodium alginate and type B gelatin at a mass ratio of 0.23:1, and the mass concentration of the drug to be loaded is 5 %, the mass concentration of biopolymer in the acidic mixed solution is 20%, the pH of the described acidic mixed solution is 3, adopt formic acid or acetic acid to adjust the pH, this is because it is a volatile acidic organic solvent, which is convenient for post-drying can be volatilized;

[0049] Step 2, loading the acidic mixed solution into the feeding device of the electrospinning equipment, and performing electrospinning to prepare a composite polymer nanofiber membrane;

[0050] Step 3: Soak the composite polymer nanofiber membrane in an alkaline ethanol solution with a grad...

Embodiment 3

[0055] The invention provides a method for preparing a drug-loaded biopolymer composite nanofiber membrane, comprising the following steps:

[0056] Step 1, dissolving an acidic mixed solution containing a drug to be loaded and a biopolymer, the biopolymer is composed of oxidized sodium alginate and type B gelatin at a mass ratio of 0.45:1, and the mass concentration of the drug to be loaded is 8 %, the mass concentration of biopolymer in the acidic mixed solution is 40%, the pH of the described acidic mixed solution is 4, adopt formic acid or acetic acid to adjust the pH, this is because it is a volatile acidic organic solvent, which is convenient for post-drying can be volatilized;

[0057] Step 2, loading the acidic mixed solution into the feeding device of the electrospinning equipment, and performing electrospinning to prepare a composite polymer nanofiber membrane;

[0058] Step 3: Soak the composite polymer nanofiber membrane in an alkaline ethanol solution with a grad...

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Abstract

The invention discloses a drug-loaded biopolymer compound nanofiber membrane and a preparation method thereof. The method includes the following steps that firstly, an acidic mixed solution where drug to be loaded and biopolymer are dissolved is prepared; secondly, the acidic mixed solution is contained in a feeding device of electrostatic spinning equipment for electrostatic spinning, and a compound polymer nanofiber membrane is prepared; thirdly, the compound polymer nanofiber membrane is sequentially placed into alkaline ethyl alcohol solutions with the volume fractions of ethyl alcohol gradually reduced to be soaked for at least two times of cross-linking; fourthly, the cross-linked compound polymer nano cellulose membrane is washed with a neutral ethyl alcohol solution with the volume fraction not higher than those of alkaline ethyl alcohol solutions used for cross-linking for many times, and the drug-loaded biopolymer compound nanofiber membrane is obtained after drying. The drug-loaded biopolymer compound nanofiber membrane can maintain a relatively stable fiber structure in the wound healing stage, the shape of a spinning membrane is kept, and drug loaded on the membrane can be continuously released.

Description

technical field [0001] The invention relates to the field of polymer nanofiber membranes. More specifically, the present invention relates to a drug-loaded biopolymer composite nanofiber membrane and a preparation method thereof. Background technique [0002] In contemporary medicine, infection is still an important factor affecting wound healing, which can significantly reduce the survival rate after surgery and trauma. The duration of pedicure and effective antibiotic therapy are key factors in controlling infection. Due to its porosity, the electrospun fiber membrane can provide good air exchange to the wound, and can absorb the exudate of the wound. The electrospun fiber membrane made of hydrophilic material has good biocompatibility and is Currently an advanced wound dressing. [0003] Alginic acid is a kind of polysaccharide extracted from brown algae. Alginate has good biocompatibility, low toxicity and relatively low price, but its degradation rate is very slow, a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00D06M13/144D06M101/06
CPCA61L26/0052A61L26/0066A61L2300/406D06M13/144D06M2101/06C08L5/04
Inventor 谭琳谭琛
Owner GUANGXI YIDEJIA MEDICAL EQUIP CO LTD
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