Paint for medical instrument, and preparation method and application thereof

Abstract

The invention belongs to the technical field of biological materials, and particularly relates to a paint for a medical instrument, and a preparation method and application thereof. The paint comprises the following components: metal salt, polyphenol and an oxidizing agent, wherein the metal salt is selected from zinc salt and strontium salt. The medical instrument comprises a base material and a coating on the surface of the base material; and the coating is formed by the paint. The paint is applied to medical instruments through interaction of the zinc salt, the strontium salt, the polyphenol and the oxidizing agent, and has the advantages of uniform film formation, no influence on the biocompatibility of the base material, improvement of the antibacterial property and the osteogenesis promoting effect, wide application range, simple and convenient preparation process, good repeatability, strong controllability and the like.

Description

technical field

[0001] The invention belongs to the technical field of biomaterials, and in particular relates to a coating for medical devices, a preparation method and application thereof. Background technique

[0002] In recent years, biomaterials have been used to construct medical devices or implants to replace diseased or lost biological outcomes. The biologically inert surface of orthopedic implants is the biggest obstacle for biomedical applications. Although implant materials such as metals, ceramics, and polymer materials are widely used in orthopedic surgery, there are still problems such as infection risk and poor osteogenesis. In the prior art, the commonly used solutions to infection and bone formation problems are the use of antibiotics, antibacterial metal ions, hydroxyapatite, etc., but it is difficult and complicated to solve infection and bone formation problems at the same time.

[0003] Therefore, it is necessary to develop a new type of medical device ...

Examples

Embodiment 1

[0065] A coated titanium substrate comprises a 1×1×2 cm titanium substrate and a coating formed by paint on the surface of the titanium substrate. The raw material components for preparing this coating include: 40mg epigallocatechin gallate, 20mg zinc acetate, 41mg strontium chloride, 20mg ammonium persulfate, 40mL phosphate buffered saline solution (i.e. PBS buffer, pH value is 8.0) .

[0066] The preparation method of the above-mentioned coated titanium substrate comprises the following steps:

[0067] (1) Place the titanium base material in acetone, ethanol, and deionized water for ultrasonic cleaning for 15 minutes in order to obtain the cleaned titanium base material;

[0068] (2) Soak the cleaned titanium substrate in a sodium hydroxide solution (molar concentration: 4mol / L) at 60°C for 8 hours to obtain the soaked titanium substrate;

[0069] (3) Place the soaked titanium substrate in deionized water for ultrasonic cleaning for 20 minutes, and dry to obtain the pretre...

Embodiment 2

[0073] A coated polyetheretherketone comprises polyetheretherketone and a coating formed by paint on the surface of the polyetheretherketone. The polyether ether ketone is a cylinder with a diameter of 1 cm and a height of 3 cm.

[0074] The raw material components for preparing the coating include: 20mg epigallocatechin gallate, 30mg zinc acetate, 30mg strontium chloride, 30mg ammonium persulfate, 40mL tris hydrochloride solution (i.e. Tris-HCl buffer, pH 7.5).

[0075] The preparation method of the polyether ether ketone covered by the above coating comprises the following steps:

[0076] (1) Put the polyetheretherketone in acetone, ethanol, and deionized water for 10 minutes to ultrasonically clean it respectively to obtain the cleaned polyetheretherketone;

[0077] (2) Soak the cleaned polyetheretherketone in a sodium hydroxide solution (molar concentration: 3mol / L) at 60°C for 5 hours to obtain the soaked polyetheretherketone;

[0078] (3) Place the soaked polyether et...

Embodiment 3

[0082] A coated medical ceramic sheet comprises a medical ceramic sheet of 1 x 1 x 3 cm and a coating formed of paint on the surface of the medical ceramic sheet.

[0083] The raw material components for preparing the coating include: 40mg epigallocatechin gallate, 30mg zinc acetate, 30mg strontium chloride, 40mg ammonium persulfate, 40mL tris hydrochloride solution (i.e. Tris-HCl buffer, pH 7.5).

[0084] The preparation method of the above-mentioned coated medical ceramic sheet comprises the following steps:

[0085] (1) Place the medical ceramic sheet in acetone, ethanol, and deionized water for 10 minutes for ultrasonic cleaning respectively to obtain the cleaned medical ceramic sheet;

[0086] (2) Soak the cleaned medical ceramic sheet in a sodium hydroxide solution (molar concentration: 3mol / L) at 70°C for 6 hours to obtain the soaked medical ceramic sheet;

[0087] (3) Ultrasonic cleaning of the soaked medical ceramic sheet in deionized water for 10 minutes, and dryin...

technical field

[0001] The invention belongs to the technical field of biomaterials, and in particular relates to a coating for medical devices, a preparation method and application thereof. Background technique

[0002] In recent years, biomaterials have been used to construct medical devices or implants to replace diseased or lost biological outcomes. The biologically inert surface of orthopedic implants is the biggest obstacle for biomedical applications. Although implant materials such as metals, ceramics, and polymer materials are widely used in orthopedic surgery, there are still problems such as infection risk and poor osteogenesis. In the prior art, the commonly used solutions to infection and bone formation problems are the use of antibiotics, antibacterial metal ions, hydroxyapatite, etc., but it is difficult and complicated to solve infection and bone formation problems at the same time.

[0003] Therefore, it is necessary to develop a new type of medical device ...

Examples

Embodiment 1

[0065] A coated titanium substrate comprises a 1×1×2 cm titanium substrate and a coating formed by paint on the surface of the titanium substrate. The raw material components for preparing this coating include: 40mg epigallocatechin gallate, 20mg zinc acetate, 41mg strontium chloride, 20mg ammonium persulfate, 40mL phosphate buffered saline solution (i.e. PBS buffer, pH value is 8.0) .

[0066] The preparation method of the above-mentioned coated titanium substrate comprises the following steps:

[0067] (1) Place the titanium base material in acetone, ethanol, and deionized water for ultrasonic cleaning for 15 minutes in order to obtain the cleaned titanium base material;

[0068] (2) Soak the cleaned titanium substrate in a sodium hydroxide solution (molar concentration: 4mol / L) at 60°C for 8 hours to obtain the soaked titanium substrate;

[0069] (3) Place the soaked titanium substrate in deionized water for ultrasonic cleaning for 20 minutes, and dry to obtain the pretre...

Embodiment 2

[0073] A coated polyetheretherketone comprises polyetheretherketone and a coating formed by paint on the surface of the polyetheretherketone. The polyether ether ketone is a cylinder with a diameter of 1 cm and a height of 3 cm.

[0074] The raw material components for preparing the coating include: 20mg epigallocatechin gallate, 30mg zinc acetate, 30mg strontium chloride, 30mg ammonium persulfate, 40mL tris hydrochloride solution (i.e. Tris-HCl buffer, pH 7.5).

[0075] The preparation method of the polyether ether ketone covered by the above coating comprises the following steps:

[0076] (1) Put the polyetheretherketone in acetone, ethanol, and deionized water for 10 minutes to ultrasonically clean it respectively to obtain the cleaned polyetheretherketone;

[0077] (2) Soak the cleaned polyetheretherketone in a sodium hydroxide solution (molar concentration: 3mol / L) at 60°C for 5 hours to obtain the soaked polyetheretherketone;

[0078] (3) Place the soaked polyether et...

Embodiment 3

[0082] A coated medical ceramic sheet comprises a medical ceramic sheet of 1 x 1 x 3 cm and a coating formed of paint on the surface of the medical ceramic sheet.

[0083] The raw material components for preparing the coating include: 40mg epigallocatechin gallate, 30mg zinc acetate, 30mg strontium chloride, 40mg ammonium persulfate, 40mL tris hydrochloride solution (i.e. Tris-HCl buffer, pH 7.5).

[0084] The preparation method of the above-mentioned coated medical ceramic sheet comprises the following steps:

[0085] (1) Place the medical ceramic sheet in acetone, ethanol, and deionized water for 10 minutes for ultrasonic cleaning respectively to obtain the cleaned medical ceramic sheet;

[0086] (2) Soak the cleaned medical ceramic sheet in a sodium hydroxide solution (molar concentration: 3mol / L) at 70°C for 6 hours to obtain the soaked medical ceramic sheet;

[0087] (3) Ultrasonic cleaning of the soaked medical ceramic sheet in deionized water for 10 minutes, and dryin...

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