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Swelled polymer particles filter process for preparing artificial eye holder

A technology of swelling polymerization and prosthetic eye table, applied in the field of biomedicine, can solve the problems of rejection, the fat layer is easily absorbed, the plastic is easy to slip out, etc., and achieves the effect of low material density

Inactive Publication Date: 2003-01-15
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some materials such as glass, gold plating, plastic, cartilage, fat layer, silicone, etc. have been used in the early days, but they are not ideal due to complications of varying degrees, such as: plastic is easy to slip out, fat layer is easy to be absorbed, silicone There are rejection reactions, etc. The biggest disadvantage of these materials is that they cannot fix the eye muscles and endow the prosthetic eye with vitality and vitality.
At present, the use of artificial synthetic materials is mainly concentrated on porous substances such as polyethylene (MEDPORE, porouspolyethylene), aluminum oxide (Al 2 o 3 ), ceramics and hydroxyapatite (HA), etc., but these materials are prone to inflammatory reactions due to their hard surfaces

Method used

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  • Swelled polymer particles filter process for preparing artificial eye holder
  • Swelled polymer particles filter process for preparing artificial eye holder
  • Swelled polymer particles filter process for preparing artificial eye holder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. Sieve NaCl with a particle size in the range of 450 microns to 520 microns through a standard sieve.

[0024] 2. Stir and mix polyether polyurethane saturated solution (solvent is tetrahydrofuran) with NaCl, the mass ratio of solution: NaCl is 1:2, pour it into a mold, compact it tightly, and obtain a spherical semi-finished product through natural volatilization and vacuum drying.

[0025] 3. Take 10 ml of 2-ethoxyethyl methacrylate (EEMA), 0.1 g of divinyl glycol, and 40 mg of AIBN in a beaker to prepare a solution.

[0026] 4. Put the trimmed spherical semi-finished product in a beaker, add the solution prepared in 3, until the spherical semi-finished product is submerged, pass nitrogen protection, seal, and swell for 3 hours.

[0027] 5. Take out the spherical semi-finished product, put it into a beaker, pass through nitrogen protection, seal it, and polymerize it at 70°C for 24 hours.

[0028] 6. Take out the reacted sphere and put it in deionized water. At 25°...

Embodiment 2

[0030] 1. Sieve white granulated sugar with a particle size within the range of 450 microns to 520 microns through a standard sieve

[0031] 2. Stir and mix polyester polyurethane saturated solution (solvent is tetrahydrofuran) and white granulated sugar, the mass ratio of solution:white granulated sugar is 1:2.5, pour into the mold, compact compactly, obtain spherical semi-finished product through natural volatilization and vacuum drying.

[0032] 3. Take 10 ml of 2-hydroxyethyl methacrylate (HEMA), 0.1 g of N, N-methylenebisacrylamide, and 40 mg of ABVN in a beaker to prepare a solution.

[0033] 4. Put the trimmed spherical semi-finished product in a beaker, add the solution prepared in 3, until the spherical semi-finished product is submerged, pass nitrogen protection, seal, and swell for 10 hours.

[0034] 5. Take out the spherical semi-finished product, put it into a beaker, pass it into nitrogen protection, seal it, and irradiate it with ultraviolet light for 5 hours. ...

Embodiment 3

[0037] 1. Sieve NH with a particle size in the range of 300 microns to 400 microns through a standard sieve 4 HCO 3 .

[0038] 2. Mix PHB saturated solution (solvent is chloroform) with NH 4 HCO 3 Stir to mix, solution: NH 4 HCO 3 The mass ratio is 1:3, poured into a mold, compacted tightly, and obtained a spherical semi-finished product through natural volatilization and vacuum drying.

[0039] 3. Take 7 ml of 2-hydroxyethyl methacrylate (HEMA), 3 ml of methacrylic acid (MA), 0.1 g of N, N-methylenebisacrylamide, and 50 mg of ammonium persulfate in a beaker to prepare a solution .

[0040] 4. Put the trimmed spherical semi-finished product in a beaker, add the solution prepared in 3, until the spherical semi-finished product is submerged, pass nitrogen protection, seal, and swell for 36 hours.

[0041] 5. Take out the spherical semi-finished product, put it into a beaker, pass through nitrogen protection, seal it, and polymerize it at 60°C for 36 hours.

[0042] 6. Ta...

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Abstract

A process for preparing artificial eye ball includes such steps as dissolving the biocompatible polymer in solvent to obtain saturated solution, mixing it with sieved pore-forming agent (300-600 microns), die pressing to obtain circular ball, volatilizing solvent, immersing the ball in the swelling solution prepared from trigger, cross-linking agent and polymer monomer, introducing nitrogen gas, sealing, swelling for 3-100 hr, putting the ball in reactor, introducing nitrogen gas, sealing, polymerizing, and immersing the ball in deionized water for 72 hr. Its advantages are high precision of size, high porosity (more than 80%), and high performance.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a preparation method of an artificial eye platform for filling eye sockets. Background technique [0002] Prosthetic eye sockets are eye socket fillers that reduce the volume of the eye socket after enucleation or enucleation of the eye, and are used to prevent postoperative eye socket deformity and entropion. It also has therapeutic and cosmetic effects. Some materials such as glass, gold plating, plastic, cartilage, fat layer, silicone, etc. have been used in the early stage, but they are not ideal due to complications of varying degrees, such as: plastic is easy to slip out, fat layer is easy to be absorbed, silicone There are rejection reactions, etc. The biggest disadvantage of these materials is that they cannot fix the eye muscles and endow the prosthetic eye with vitality and vitality. At present, the use of artificial synthetic materials is mainly concentrated on porous substanc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/14A61L27/14C08J9/16
Inventor 胡平施一平
Owner TSINGHUA UNIV
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