Self-repairing fast sealing medical adhesive and production method thereof

A self-healing and fast technology, applied in pharmaceutical formulations, applications, pharmaceutical sciences, etc., can solve problems such as limitations, and achieve the effects of fast gel formation, high gel breaking strength, and reduced blood effects.

Active Publication Date: 2020-03-27
SHANDONG BRANDEN MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the biological damage or hemostatic reagents described in this patent require ultraviolet light for excitation, which limits its application in the human body where ultraviolet light cannot be used to irradiate tissues, and has limitations.

Method used

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  • Self-repairing fast sealing medical adhesive and production method thereof
  • Self-repairing fast sealing medical adhesive and production method thereof
  • Self-repairing fast sealing medical adhesive and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Dissolve 1 g of aminated gelatin with a molecular weight of 15-25 KDa and an amino molar ratio of 80% in 10 ml of a phosphate buffer solution with a pH value of 7.4, and mechanically stir to dissolve into a uniform solution to obtain solution A.

[0037] Dissolve 1.25g of esterified modified aldehyde sodium alginate with a molecular weight of 80-120KDa, an aldehyde molar ratio of 80%, and a succinimide glutarate group (SG) molar ratio of 80% in 10ml, pH In the phosphate buffer solution with a value of 7.4, dissolve it into a uniform solution with mechanical stirring to obtain solution B.

[0038] The solution A and the solution B are poured into two syringes in the double syringe respectively, and the medical glue is formed through the mixing and atomization of the double syringe.

Embodiment 2

[0040] Dissolve 0.2 g of aminated hyaluronic acid with a molecular weight of 2500-3000 KDa and an amino molar ratio of 40% in 10 ml of a borate buffer solution with a pH value of 10, and mechanically stir to form a uniform solution to obtain solution A.

[0041] Dissolve 0.2g of esterified modified aldehyde-based chitosan with 2000-3000KDa, aldehyde group molar ratio of 40%, succinimide sebacate group (-SSeb) molar ratio of 40% in 10ml, pH 4 in the phosphoric acid solution, dissolved into a homogeneous solution with mechanical stirring to obtain solution B.

[0042]The solution A and the solution B are poured into two syringes in the double syringe respectively, and the medical glue is formed through the mixing and atomization of the double syringe.

Embodiment 3

[0044] Dissolve 2 g of aminated polylysine with a molecular weight of 3-10 KDa and an amino molar ratio of 60% in 10 ml of carbonate buffer solution with a pH value of 8.5, mechanically stir and dissolve to form a uniform solution to obtain solution A.

[0045] Dissolve 2 g of esterified modified aldehyde dextran with a molecular weight of 3-5 KDa, a molar ratio of aldehyde groups of 60%, and a molar ratio of succinimide succinate groups (-SS) of 60% in 10ml, pH 5.5 in acetic acid solution, mechanically stirred and dissolved into a homogeneous solution to obtain solution B.

[0046] The solution A and the solution B are poured into two syringes in the double syringe respectively, and the medical glue is formed through the mixing and atomization of the double syringe.

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Abstract

The invention discloses a self-repairing fast sealing medical adhesive and a production method thereof. The medical adhesive is formed by conducting covalent cross-linking after two components are subjected to physical mixing through a mixing tool, wherein the first component is composed of aldehyde group macromolecules subjected to esterification modification, and the second component is composedof amino-modified macromolecules. According to the self-repairing fast sealing medical adhesive and the production method thereof, by adjusting a ratio of esterification groups to aldehyde groups toamino groups and concentrations of the esterification groups, the aldehyde groups and the amino groups, the adhesive forming time, the rupture strength and adhesion to wounds of the medical adhesive can be adjusted. According to the self-repairing fast sealing medical adhesive and the production method thereof, by adjusting concentrations of the first component and the second component, the viscosity and the density of the medical adhesive before the medical adhesive is formed can be adjusted so that blood effects can be reduced. The medical adhesive has a high amino group content, and thus has certain bacteriostatic ability. When the medical adhesive is formed, dynamic bonds can be formed, so that the medical adhesive has a certain self-repairing function. Therefore, the medical adhesivehas the efficacy of fast efficient hemostasis, self-repairing and baceriostasis.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a self-repairing quick-sealing medical glue and a preparation method thereof. Background technique [0002] In surgical operations, rapid, effective and safe hemostasis is one of the key factors to ensure the success of the operation. Excellent medical glue can control wound bleeding or tissue fluid, ensure a clear surgical field of vision, improve surgical efficiency, and accelerate postoperative recovery of patients. [0003] A variety of medical glues have been developed at home and abroad, mainly including animal-derived medical glue, semi-synthetic material medical glue and synthetic material medical glue, among which animal-derived medical glue is divided into fibrin glue containing thrombin (such as double-embroidered glue and Nursing Lace) and collagen and gelatin (such as fluid gelatin (surgiflo)); semi-synthetic medical glue is divided into gelatin-resorcinol formal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/10A61L24/08A61L24/04
CPCA61L24/001A61L24/043A61L2400/04C08L89/00C08L5/04C08L5/08C08L77/04C08L5/02C08L5/12C08L75/02C08L1/286
Inventor 张海军袁坤山王如蒙卢沙张淑欣鲁手涛尹玉霞段翠海侯文博
Owner SHANDONG BRANDEN MEDICAL DEVICE
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