The invention discloses a preparation method for producing deep-drawn cold-formed medicinal aluminum foil with a cast-rolling billet in a short process. The method sequentially includes the steps of smelting, cast rolling, cold rolling, homogeneous high-temperature treatment, intermediate rolling, slitting shear trimming, intermediate annealing, finish rolling, foil rolling, coil combining, finished product rolling, parting-off, and furnace loading for annealing. Raw materials of the deep-drawn cold-formed medicinal aluminum foil include an aluminum alloy and an Al-Fe intermediate alloy with amass content of 20% or a Fe-containing additive with a mass content of 75%, and elements in the aluminum alloy include 0.025-0.10% of Si, 1.25-1.65% of Fe, 0.001-0.10% of Cu, less than 0.05% of Mn, less than 0.05% of Mg, less than 0.05% of Cr, less than 0.05% of Zn, 0.01-0.04% of Ti and the balance A. By means of the recorded preparation method, final product detection shows that the end face layer offset after parting-off is less than or equal to 0.5 mm, the width of the corrugated edge is 3 mm, and the peak value is 1 mm; the surface cleanliness dyne value is greater than or equal to 65 dyn; as for mechanical properties, the tensile strength is 80-115 MPa, the elongation rate is 23%, and the yield ratio is 42%; and the Erichsen value is 5.0 mm, the deep drawing height is 2.0 mm, the surface hardness value is 22 HV, the bursting strength is 400-800 Ka, and the surface swabbing reaches level A.