The present invention provides a radioactive drugsolution synthesis apparatus and a method for cleaning replacement modules that can suppress the retention of residual substances in the line. [Solution] The radioactive drugsolution synthesis apparatus 10 introduces cleaning solution into one container and overflows the cleaning solution from the other container to introduce it into the suction line. This allows the suction line to be cleaned with the cleaning solution. Here, target water does not actually pass through the vacuum lines L2 and L9, but rather volatile vapor adheres to them. There was a need to easily clean such residues. In response to this, the vacuum lines L2 and L9 can be cleaned with a simple operation of overflowing cleaning solution from one container, without adding any mechanisms.