Rapidly degradable chemical bond based PEG hydrogel and preparation method and applications thereof

A rapid degradation and chemical bond technology, applied in the field of PEG hydrogel, can solve the problems of inability to ensure complete removal and increase the risk of use, and achieve excellent hemostatic effect, good biocompatibility, and fast gelation.

Active Publication Date: 2018-09-14
深圳宁聚生物新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And when the operation is wrong, these traditional hemostatic sealants can only be remov

Method used

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  • Rapidly degradable chemical bond based PEG hydrogel and preparation method and applications thereof
  • Rapidly degradable chemical bond based PEG hydrogel and preparation method and applications thereof
  • Rapidly degradable chemical bond based PEG hydrogel and preparation method and applications thereof

Examples

Experimental program
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Example Embodiment

[0080] Example 1,

[0081] Weigh 130 mg of four-arm polyethylene glycol amino (as shown in formula II, where m is 56) and dissolve it in 1 ml of physiological saline to obtain mixed solution 1 (mass-volume concentration of 130 mg / ml), and weigh 120 mg of four-arm poly Ethylene glycol succinimide ester (as shown in formula VI, where n is 56) and 10mg four-arm polyethylene glycol aldehyde group (as shown in formula X, where p is 56 and R is formula a) Obtain mixed solution 2 (mass-volume concentration of 120mg / ml and 10mg / ml, respectively) in 1ml of physiological saline; draw a mixed solution with one of the double-barreled syringes, and then inject it into a cylindrical glass mold, 30 minutes later Take it out and measure the compressive strength with a universal tensile machine, such as figure 1 As shown, the strength can reach 1.2 MPa, and the strength is high.

[0082] Degradation test: Prepare a cylindrical gel with a diameter of 1 cm and a height of 1 cm according to the above...

Example Embodiment

[0085] Example 2,

[0086] Weigh 200mg four-arm polyethylene glycol amino (as shown in formula II, where m is 112) and dissolve it in 1ml PBS solution to obtain mixed solution 1 (mass-volume concentration is 200mg / ml), weigh 200mg four-arm poly Ethylene glycol succinimide ester (as shown in formula VI, where n is 112) and 200mg four-arm polyethylene glycol aldehyde group (as shown in formula X, where p is 112 and R is formula b) Obtain mixed solution 2 (both mass-volume concentration is 200mg / ml) in 1ml PBS; draw a mixed solution with one of the double-barreled syringes, and then inject it into the transparent sample bottle at the same time, invert the sample bottle, and the time when the liquid does not flow Is the gel time. Such as figure 2 As shown, the gel time of this system is 10s, the gel forming speed is fast, and it can form quickly on the surface of the object.

[0087] The degradation performance of the hydrogel prepared in this example was tested according to the met...

Example Embodiment

[0089] Example 3.

[0090] Weigh 100mg six-arm polyethylene glycol amino (as shown in formula III, where m is 28) and dissolve it in 1ml PBS solution to obtain mixed solution 1 (mass-volume concentration 100mg / ml), and weigh 200mg two-arm poly Ethylene glycol succinimide ester (as shown in formula V, where n is 56) and 50mg four-arm polyethylene glycol aldehyde group (as shown in formula X, where p is 34 and R is formula b) Obtain mixed solution 2 (mass-volume concentration of 200mg / ml and 50mg / ml respectively) in 1ml PBS; draw a mixed solution with one of the double-barreled syringes, and then coat it on the surface of the broken pig skin, using universal tension The machine measures the pulling force required for the pigskin to separate again, which is the adhesive strength of the gel. Such as image 3 As shown, the adhesion strength is 36 kPa, indicating that the gel can adhere to the surface of pigskin well and has high strength.

[0091] The degradation performance of the hy...

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Abstract

The invention discloses a rapidly degradable chemical bond based PEG hydrogel and a preparation method and applications thereof. The hydrogel is formed by respectively connecting a polyethylene glycolderivative 1 (polyethylene glycol amino) with a polyethylene glycol derivative 2 (polyethylene glycol succinimide ester) and a polyethylene glycol derivative 3 (polyethylene glycol aldehyde group) through a chemical bond 1 and a chemical bond 2; and the chemical bond 1 is beta-carbonyl amide bond, and the chemical bond 2 is schiff base bond. The PEG hemostasis sealing hydrogel has potential applications in the following fields: drug slow releasing materials; tissue engineering scaffolds; medical sponges; visceral organ hemostatic sealants; surface coatings of medical implants; epidermis hemostatic sealing coatings; coatings for burn treatment; and tissue adhesion preventing materials. The gelation speed of the PEG hemostasis sealing hydrogel is fast; the hydrogel can be rapidly formed onthe surfaces of objects and rapidly degraded in the body and on the body surfaces; the hydrogel has excellent hemostasis effects and good biocompatibility, and can be rapidly cleared (disappeared).

Description

technical field [0001] The invention relates to a PEG hydrogel, in particular to a PEG hemostatic hydrogel based on rapidly degradable chemical bonds, a preparation method and application thereof. Background technique [0002] Hydrogel is a soft material that can absorb a large amount of water and has a three-dimensional network structure. Hydrogels are widely used in fields such as biomedicine, agriculture, industry, and environmental protection because of their high water absorption and good biocompatibility. In terms of biomedicine, hydrogels have been used in drug carriers, cell carriers, dressings, masks, and artificial corneas. However, for some special biomedical needs, especially the hemostatic seal of organs, it is necessary to gel quickly, have high strength, and can be quickly degraded. If the operation is wrong during use, it needs to be quickly removed. [0003] In recent years, various hydrogels have been developed for hemostatic seals. Currently commerciall...

Claims

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Application Information

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IPC IPC(8): A61L27/52A61L27/18A61L27/54A61L27/50A61L31/14A61L31/06A61L31/16A61L31/10A61L24/00A61L24/04A61L26/00C08G81/00
CPCA61L24/001A61L24/0015A61L24/0031A61L24/046A61L26/0019A61L26/0061A61L26/0066A61L26/008A61L27/18A61L27/50A61L27/52A61L27/54A61L31/06A61L31/10A61L31/14A61L31/145A61L31/16C08G81/00C08L87/00
Inventor 吴德成补亚忠杨飞
Owner 深圳宁聚生物新材料科技有限公司
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