The invention provides 
hydroxypropyl chitosan microspheres as well as a preparation method thereof and application thereof in reduction of 
dielectric loss of 
vegetable oil, belonging to the field of 
chitosan modification. The preparation method of the 
hydroxypropyl chitosan microspheres comprises the following steps: mixing 
chitosan, having 
viscosity of 0.25-0.65Pa.s with isopropanol and a first 
sodium hydroxide solution, adding tetramethyl 
ammonium hydroxide into the mixture, dropwise adding epoxypropane for carrying out a reaction, cooling and adjusting the pH value to 7, dispersing the product into 
acetone or water, stirring and carrying out suction 
filtration, washing with 
anhydrous ethanol, and carrying out 
vacuum drying to obtain 
hydroxypropyl chitosan; preparing the hydroxypropyl 
chitosan into a solution, spraying the solution onto 
sodium polyphosphate, carrying out ultrasonic treatment and crosslinking, then washing with water, filtering, adding the product into a 
sodium hydroxide solution and stirring, and adding 
glutaraldehyde for carrying out a reaction so as to obtain microspheres; washing the microspheres with water, then leaching the microspheres respectively with organic solvents with volume percentages of 21-29%, 41-49%, 61-69% and 85-89%, and carrying out 
freeze drying. The modified chitosan prepared by the method can reduce the 
dielectric loss of the vegetableoil.